Objective To investigate the effects of Quercetin(QC) on oxidative stress induced by exhausted swimming in rats,so as to provide scientific basis for developing anti-fatigue food.Methods Male SD rats were randomly divided into resting control group,exhausted swimming group,and exhausted swimming with administration of Quercetin group.The content of malondialdehyde(MDA),the activity of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px) in blood serum were measured.At the same time the survival time after exhausted swimming was determined.Results The survival time in exhausted swimming+Quercetin group was longer than exhausted swimming group((348.5±52.4)min vs(171.7±37.1)min,P0.01).The content of MDA in exhausted swimming+QC group was lower((4.4±1.0) nmol/ml vs(6.2±1.9) nmol/ml,P0.01),whereas the activity of SOD,and GSH-Px was higher((105.0±3.4)U/ml vs(80.5±4.2)U/ml,(873.6±72.3)U/ml vs(538.6±63.6)U/ml respectively,P0.01)than in exhausted swimming group.Conclusion Quercetin could increase the antioxidative enzyme activity,decrease the lipid peroxidation,thus enhance the ability of exercise in exhausted fatigue rats.

Thirty six SD male rats weighted 80~100 g were randolnly divided into three grougs,and fed on diets as follows:control(Cu 13.15 mg/kg),copper toxic I(Cu 650 mg/kg)and copper toxic Ⅱ(Cu 850 mg/kg)for studying effects of copper toxicity on liver in rats by the methods of experimental pathology for nine weeks for exploring the effect of high diet copper on some liver parameters.The result showed that lesions were appeared in high copper groupsⅠ and Ⅱ when compared those with control group.There were increased the liver of rats coefficien in high copper groupsⅠ and Ⅱ(P0.05).Also,LDH,GOT and liver copper contents in high copper groupsⅠand Ⅱ were much higher in the control group(P0.01).The control group SOD activities were higher in high copper groupⅠand Ⅱ the dietary copper in range of 650~850 mg/kg caused pathological injures in liver of SD rats.