Objective To discuss the mechanism of elevated postoperative serum parathyroid hormone(PTH) levels with normocalcemia in patients who undergoing successful parathyroidectomy for primary hyperparathyroidism.Methods PTH levels were measured in 97 patients 6 months after parathyroidectomy.The 25-OH-vitamin D levels,serum alkaline phosphatase levels,osteocalcin and bone densitometry were evaluated before operation and 6 months after surgery.PTH reactivity to calcium loading was tested six months postoperatively.Results Thirty patients had elevated PTH levels with normocalcemia after parathyroidectomy.Before surgery,these patients had higher PTH and creatinine levels,lower vitamin D levels,and more extensive change of bone than those with normal postoperative PTH levels.There were 67 patients whose PTH was normal after surgery with normal renal function and vitamin D levels,and without change in bones condition.Conclusions The elevated PTH levels after surgery for primary hyperparathyroidism is an adaptive reaction to renal dysfunction or vitamin D deficiency.

Objective:To study the effect of Chaiqinchengqi Decoction treating acute severe pancreatitis(ASP).Methods:33 cases of ASP(male 21 cases,female 12 cases),were divided into two groups by the different therapy:group1 used clinical medicine combined with Chinese traditional medicine(23 patients),group 2 only used clinical medicine(10 patients). We chose Chaiqinchengqi Decoction as the traditional Chinese medicine.Results:33 cases of patients were all cured and discharge.However,the two groups were different in the duration,expense,time of continuing sleep and the time of stool. The group 1 was better than group 2.The usage of analgesic in group 1 were lower than that of group 2.Conclusion:The effect of Chaiqinchengqi Decoction is significant in treating acute severe pancreatitis(ASP).The therapy combined with Chinese traditional medicine and clinical medicine is preferred to clinical medicine.

Objective To study the effects of As_2O_3 on tumor model of hepatocarcinoma.Methods HepAgrafed hepatocarcinoma mouse model was established by subcutaneously injection of mouse hepatoma cells(1×10~6)into the oxter of mice.After treated by As_2O_3,the volume change of tumor and tumor inhibition rates were observed.The expression of vascular endothelial growth factor(VEGF) was detected by immunohistochemical and calculated the difference of MVD.Results The volume of tumor and the tumor inhibition rates were significantly decreased in As_2O_3 group compared with control group(P<0.05).The As_2O_3 could inhibit angiogenesis of xenograft tumor,depress expression of VEGF and decrease microvascular density(MVD).Conclusion As_2O_3 can inhibit the growth of tumor,inhibit the expression of VEGF and decrease MVD.

目的:评价银杏制剂联合养血清脑颗粒对脑卒中后记忆减退的治疗效果。方法:选择脑卒中后记忆减退患者90例,随机分为治疗组和淀粉对照组,每组各45例,实验组服养血清脑颗粒4.0g/次,3次/d,共4周;同时服用银杏叶片剂2片/次,3次/d,共2周。对照组服淀粉4.0g/次,3次/d,共4周。于治疗前和治疗4周后进行记忆商的测定,同时观察不良反应。结果:按临床疗效标准,实验组总有效率75.56%,对照组为33.33%,2组有显著差别(P<0.05)。患者的记忆力提高,实验组平均增值16±10分(x±s,),对照组平均增值4±2分,2组间比较P<0.05。实验组无明显不良反应。结论:银杏制剂联合养血清脑颗粒对脑卒中后的记忆减退有良好的恢复作用。

Objective:To investigate the protection of Danshen on tubular cell induced by renal ischemia reperfusion injury in rats.Methods:Male,Wistar rats were randomly divided into 4 groups:sham surgery group,model group(renal ischemia reperfusion injury group),medication group 1(drug given before renal ischemia reperfusion 24 hours) and medication group 2(drug given after renal ischemia reperfusion 12 hours).Renal ischemia reperfusion injury models were set up by clamping both sides of renal arteries 22 minutes.The level of serum creatimine and blood urea nitrogen was measured by colorimetry,protein expressions of renal cysteinyl aspartate-specific protease(caspase-3) were detected by western blotting.Cell apoptosis was confirmed by Terminal Deoxynucleotidyl Transferase Biotin-dUTP Nick End labeling(TUNEL) analysis.Results:Comparing the sham group and the model group,the kidney function decreases sharply(P0.05);protein expressions of caspase-3 increases remarkably(P0.05);lots of tubular cell apoptosis(P0.05).Using Danshen 24 huors before reperfusion was found remarkably improve renal function(P0.05),decrease the expressions of caspase-3(P0.05) and cell apoptosis(P0.05).And using this medication 12 hours after reperfusion,administrating Danshen did not show us any effect on renal function,cell apoptosis,and the expressions of caspase-3(P0.05).Conclusion:Before renal ischemia reperfusion,using Danshen for rats,that has the function of decompressing the cell apoptosis induced by renal ischemia reperfusion injury and protection the renal function.

Whipple病是一种不常见的慢性细菌感染,最常见的临床表现是,体质量下降,伴随腹泻,消化道出血和腹痛.临床诊断依靠血液检测,内镜检查和组织学活检.

目的:研究胆源性胰腺炎的危险因素,以更好预防和治疗。方法:采取病例对照研究方法,通过条件Logistic回归多因素分析我院普外科和消化科收治的325例胆源性胰腺炎患者。结果:文化程度、饮酒、血脂等6种因素系胆源性胰腺炎的危险因素,需引起我们高度重视。

利用彩超诊断和彩超监视下遥控自动双对比造影灌肠器水压灌肠复位小儿肠套叠20例,确诊率达100%,灌肠复位率达95%,效果满意,体会如下.

先天性肠系膜裂孔疝临床少见,术前难以确诊,一旦肠绞窄则严重危及生命.我院1992-11～2002-11共收治3例,回顾总结报道如下.

先天性肥厚性幽门狭窄(congenital hypertrophic pyloric stenosis,CHPS)是幽门环肌增生肥厚,使幽门腔狭窄所引起的胃输出道不全性梗阻,为新生儿常见病,我国的发病率为1‰,男性多于女性,以往诊断依靠临床和X线钡餐(GI)检查,我们对16例临床疑诊CHPS的患儿进行了彩超检查,结合GI及手术证实者对比分析,现报道如下.