Purpose This study was aimed to investigate the risk factors of necrotizing enterocolitis (NEC) in twin preterm infants. Methods The clinical data of 67 pairs of twin preterm infants admitted to the neonatal department of our hospital from January 2010 to December 2021 were retrospectively collected. One of the twins had NEC (Bell II and above) and the other twin without NEC. They were divided into NEC group and control group according to whether NEC occurred or not. Results Univariate analysis showed that NEC was associated with congenital heart disease, small for gestational age, mild asphyxia at birth and feeding intolerance ( P < 0.05). Conclusion Occurrence of NEC was associated with congenital heart disease, small for gestational age, and asphyxia at birth. For twin preterm infants with congenital heart disease, small for gestational age, or asphyxia at birth, special attention should be paid to the occurrence of NEC to minimize and avoid the occurrence of NEC.
阿尔茨海默病(AD)是一种渐进性发展的中枢神经退行性疾病.随着人口老龄化趋势的日益显现,AD的发病率也在逐年增加,其发病机制复杂,目前用于治疗AD的药物局限于胆碱酯酶抑制剂和N-甲基D-天冬氨酸(NMDA)拮抗剂,但是两者尚不能有效阻止病程进展.近些年,茶叶功能成分治疗AD的作用逐步得到证实,本文主要阐述了AD的发病机制包括β-淀粉样蛋白沉积,Tau蛋白异常聚集以及其过度磷酸化,神经炎症及炎症微环境对神经元的慢性损伤,肠道微生物群紊乱引起的中枢神经系统功能障碍,氧化应激与线粒体功能障碍,神经细胞铁死亡以及与外泌体、雌激素、糖代谢等因素的关联,同时总结了茶叶功能成分在这些方面治疗AD的分子机制,为AD的预防和治疗提供新思路.
目的 基于CiteSpace软件进行中药治疗腹腔粘连研究现状的可视化分析.方法 检索2002年1月至2022年9月中国知网期刊数据库中药治疗腹腔粘连的相关文献,关键词为腹腔粘连、腹膜粘连、肠粘连、术后粘连、中药,利用CiteSpace软件进行作者、机构、关键词可视化分析并绘制知识图谱.结果 纳入文献100篇,平均年发文量5篇.作者发文量最多6篇,为曾莉教授.机构最高发文量为5篇,为南方医科大学南方医院药学部.频次较高(≥5次)的关键词包括中药、腹腔粘连、肠梗阻、肠粘连、术后、粘连、预防、术后粘连、大承气汤.关键词聚类节点数>10的共6类.聚类主要归纳为不同的中药对腹腔粘连的实验研究和不同中药治疗在腹腔粘连的临床应用研究两部分内容.2007年突现了肠梗阻、肠粘连关键词.肠梗阻突现持续到2010年,是突现持续时间最长的关键词.结论 中药治疗腹腔粘连这一领域的年发文量相对少,是一个具有潜力和前景的研究方向.研究者和研究机构数量相对少且集中.中药治疗腹腔粘连研究的热点主要分为两方面,一方面为中药对腹腔粘连的基础实验研究,另一方面为中药对腹腔粘连的临床应用研究.
医疗新技术新项目是提升医院医疗技术水平与核心竞争力的重要内容,良好的发展环境对医疗新技术新项目而言至关重要,而规范化的管理制度则是营造健康环境的重要前提之一.本文以国家卫生健康委员会下发的医疗技术管理政策为背景,以苏州大学附属儿童医院医疗新技术新项目的管理实践为例,阐述医疗新技术新项目制度化管理的内容,包括准入管理程序、实践效果评价及控制、高风险诊疗技术授权审批管理等环节,并对医疗新技术新项目制度化管理过程中的问题、效果进行讨论,对医疗新技术的创新发展进行展望.在维系已开展医疗技术的同时注重医疗技术的创新培育,从开展环境、交流平台、资金支持等方面提供保障,以进一步促进医疗新技术新项目规范、安全、创新开展.
目的 探讨肺超声联合血清N端脑钠肽前体(NT-proBNP)在心源性及肺源性呼吸困难中的诊断价值.方法 选取2018年10月到2021年9月石家庄市第三医院收治的55例心源性呼吸困难患者以及50例肺源性呼吸困难患者作为研究对象,分别作为心源性组和肺源性组,均进行肺超声诊断以及血清NT-proBNP水平测定诊断.比较心源性组与肺源性组的血清NT-proBNP水平及阳性率、肺超声检查阳性率.以综合病理诊断为金标准诊断结果,研究肺超声联合血清NT-proBNP检测的诊断效能,包括灵敏度、特异度和准确率.结果 心源性组患者的血清NT-proBNP水平、血清NT-proBNP阳性率均高于肺源性组,肺超声阳性率低于肺源性组,差异有统计学意义(P<0.05).单独血清NT-proBNP检测对心源性呼吸困难的诊断灵敏度为100.00％(55/55),特异度为90.00％(45/50),准确率为95.24％(100/105).肺超声联合血清NT-proBNP检测对心源性呼吸困难的诊断灵敏度为100.00％(55/55),特异度为96.00％(48/50),准确率为98.10％(103/105).肺超声联合血清NT-proBNP检测与单独血清NT-proBNP检测对心源性呼吸困难的诊断灵敏度、特异度、准确率比较,差异均无统计学意义(P>0.05).单独肺超声对肺源性呼吸困难的诊断灵敏度为98.00％(49/50),特异度为96.36％(53/55),准确率为97.14％(102/105).肺超声联合血清NT-proBNP检测对心源性呼吸困难的诊断灵敏度为98.00％(49/50),特异度为100.00％(55/55),准确率为99.05％(104/105).肺超声联合血清NT-proBNP检测与单独肺超声检测对心源性呼吸困难的诊断灵敏度、特异度、准确率比较,差异均无统计学意义(P>0.05).结论 肺超声联合血清NT-proBNP在心源性及肺源性呼吸困难的诊断中,均具有较高的诊断效能,能够为心源性及肺源性呼吸困难的临床诊断提供重要的依据.
Objective To explore the rationality of the application of glucocorticoids in prenatal fetal lung maturation.Methods From 2019 to 2021,the drug use information of the first 100 patients who took glucocorticoids to promote fetal lung maturation was extracted from the electronic medical record system every year according to the order of hospitalization number,and the rationality of drug use was evaluated from the aspects of drug indication,drug timing,method of use,indication of repeated course of treatment,number of treatment courses,and interval time of each course.Results A total of 58 patients(19.3％of all patients)had no prescription,4 patients had repeated courses of medication without indication,accounting for 1.3％of all patients,168 cases of 24-36+6weeks gestation gave birth 7 d after administration,accounting for 64.1％of the patients of corresponding gestational age,132 cases of 24-36+6 weeks gestation gave birth at full term,accounting for 50.4％of the patients of corresponding gestational age.In the repeat course,12 cases gave birth 7 d after administration,accounting for 85.7％of the repeat course.Conclusion There is overuse of prenatal glucocorticoids in pro-moting fetal lung maturation in this hospital.Clinical indications should be strictly used,treatment plan should be optimized,and rational use of glucocorticoids should be used to ensure the effectiveness and safety of medication.
Objective To explore the application value of humanistic care model based on Swanson's caring theory in patients with middle and late abnormal pregnancy induced labor.Methods A total of 80 patients with middle and late abnormal pregnancy induced labor in Yichun Maternal and Child Health Hospital from January to August 2022 were selected as research objects,and divided into control group and observation group according to random number table method,with 40 cases in each group.Patients in the control group received routine nursing,while patients in the observation group received humanistic care based on Swanson's caring theory.The psychological state,labor time,and satisfaction with nursing effect were compared between the two groups.Results Before nursing,there were no statistically significant differences in the scores of Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA)between the two groups(P＞0.05).After nursing,the scores of HAMD and HAMA of the two groups were lower than those before nursing,and the scores of HAMD and HAMA of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).The first stage of labor,the second stage of labor,the third stage of labor and the total time of labor in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).The total satisfaction of nursing in observation group was higher than that in control group,the difference was statistically significant(P＜0.05).Conclusion Humanistic care model based on Swanson's caring theory in patients with middle and late abnormal pregnancy induced labor can improve the psychological state of patients,shorten the labor process,improve nursing satisfaction,and improve the quality of nursing service,which is worthy of clinical application and promotion.
Objective To explore the influencing factors of myopia progression in adolescents and the prevention and con-trol measures.Methods A total of 2 000 adolescents who underwent visual acuity examination in the Department of Oph-thalmology,the First Hospital of Nanchang from January 2019 to July 2022 were selected as the research objects.All ado-lescents underwent eye examination,including optometry and visual acuity chart.The situation of juvenile myopia and the related factors affecting the progression of juvenile myopia were analyzed.Multivariate analysis was used to analyze the fac-tors with difference.Results After visual acuity examination,a total of 1 086 adolescents were diagnosed as myopia among 2 000 adolescents,and were enrolled in the myopia group.A total of 914 non-myopic adolescents were enrolled in the non-myopic group.There were statistically significant differences between the two groups in gender,parental myopia,sleep duration,outdoor activity time,time to finish homework and reading books,and time on mobile devices(P＜0.05).Logistic analysis showed that gender(β=0.626,OR=1.869,95％CI=1.562-2.237),parental myopia(β=0.605,OR=1.831,95％CI=1.530-2.190),sleep duration(β=0.395,OR=1.484,95％CI=1.234-1.785),outdoor activity time(β=0.394,OR=1.483,95％CI=1.241-1.772),time to finish homework and reading books(β=1.095,OR=2.989,95％CI=1.968-4.539)and time on mobile devices(β=0.337,OR=1.401,95％CI=1.116-1.759)were influencing factors for visual progression in adoles-cents(P＜0.05).Conclusion There are many factors affecting the progression of myopia in adolescents.Active and targeted intervention and prevention measures should be taken to reduce and control the further development of vision.
Objective To analyze the effect of Ciclosporin combined with Low Molecular Weight Heparin Calcium in the treatment of unexplained recurrent abortion.Methods A total of 60 patients with unexplained recurrent abortion admitted to Jiangxi Maternal and Child Health Hospital from May 2019 to December 2022 were selected as research objects,and they were divided into treatment group(30 cases)and control group(30 cases)according to random number table method.The control group was treated with Low Molecular Weight Heparin Calcium,and the treatment group was supplemented with Ci-closporin on the basis of control group.The clinical efficacy,pregnancy outcome(full-term delivery,ectopic pregnancy and spontaneous abortion),CD4+/CD8+levels and human villus gonadotropin levels were compared between the two groups.Re-sults The total effective rate of treatment group was higher than that of control group,the difference was statistically signifi-cant(P＜0.05).The successful pregnancy rate in the treatment group was higher than that in the control group,and the dif-ference was statistically significant(P＜0.05).The CD4+/CD8+after treatment in the treatment group was lower than that in the control group,and the human villus gonadotropin level in the treatment group was higher than that in the control group at 1,2 and 3 weeks,the differences were statistically significant(P＜0.05).Conclusion Ciclosporin combined with Low Molecular Weight Heparin Calcium can increase the human villus gonadotropin,reduce CD4+/CD8+,promote the growth of trophoblast,gestational capsule and germ in patients with unexplained recurrent abortion,and improve the success rate of fe-tal protection.
Objective To explore the effect of spinous process lamina complex replantation combined with screw internal fixation in thoracic intravertebral tumor resection.Methods Retrospective analysis was performed on 45 patients who un-derwent thoracic intraspinal tumor resection in Yichun People's Hospital from March 2019 to August 2022.They were di-vided into three groups according to different surgical methods,with 15 cases in each group.Group A was treated with tradi-tional total laminectomy combined with pedicle screw internal fixation,group B was treated with total laminectomy spinous process and lamina complex replantation with titanium plate internal fixation,and group C was treated with total laminecto-my spinous process and lamina complex replantation with screw internal fixation.Perioperative indexes,Japanese Or-thopaedic Association(JOA)score,JOA improvement rate and postoperative spinal range were compared among the three groups.Results There were significant differences in operation time and blood loss among the three groups(P＜0.05),but no significant difference in bone healing time among the three groups(P＞0.05).The operation time and postoperative bone healing time in group C were shorter than those in group A and group B,and the intraoperative blood loss was lower than that in group A and group B,showing significant differences(P＜0.05).There was no significant difference in preoperative JOA score between the three groups(P＞0.05).There were significant differences in JOA scores among the three groups after op-eration(P＜0.05).There was no significant difference in preoperative JOA score between the three groups(P＞0.05).The postoperative JOA score of group C was higher than that of group A and group B,and the differences were statistically sig-nificant(P＜0.05).There was statistically significant difference in postoperative spinal mobility between the three groups(P＜0.05).The lumbar coronal lateral flexion and sagittal flexion and extension in group C were higher than those in group A and group B(P＜0.05).The thoracic coronal lateral flexion and horizontal rotation in group C were higher than those in group A and group B(P＜0.05).Conclusion Spinous process laminae complex replanting combined with screw fixation in thoracic intravertebral tumor resection can obtain better surgical effect,the surgery causes less trauma to patients,is con-ducive to promote the recovery of thoracolumbar function of patients,and does not affect postoperative spinal range of motion,plays an important role in promoting postoperative recovery.
Objective To study the effect of silymarin on the proliferation and apoptosis of OCI-LY-19 cells in diffuse large B lymphoma by experiment in vitro.Methods The OCI-LY-19 cells were treated with silymarin and the inhibitory effect on proliferation was detected by CCK-8 method.The apoptosis rate of cells after silymarin was analyzed by Annexin V-FITC/PI assay.Quantitative real time PCR and Western blotting methods were used to detect mRNA and protein levels of AKT and Caspase-3 in cells treated with silymarin.Results Compared with 0 ng/ml,the OCI-LY-19 cells in 10,20,50 and 100 ng/ml silymarin groups showed higher inhibitory rate of proliferation activity,with statistical significances(P＜0.05).The median inhibitory concentration(IC50)of silymarin treated OCI-LY 19 cells for 48 h was 73.27 ng/ml.After treatment with 50,100,150 ng/ml of silymarin for 48 h,the sum proportion of early and late apoptotic cells increased grad-ually compared with 0 ng/ml group,the differences were statistically significant(P＜0.05).With the increase of drug con-centration from 0 to 150 ng/ml,the mRNA expression level of AKT in OCI-LY-19 cells was gradually decreased,and the level of Caspase-3 was gradually increased,with statistical significances among all groups(P＜0.05).Compared with the control group at 0 ng/ml,with the increase of silymarin concentration,the level of AKT protein in cells gradually decreased and the level of Caspase-3 gradually increased,with statistical significances among all groups(P＜0.05).Conclusion Sily-marin may exert its antitumor effect on human diffuse large B-cell lymphoma OCI-LY-19 cells by regulating the PI3K/AKT/Caspase-3 pathway.
Objective To investigate the application effect of mindfulness-based cognitive intervention in adolescents with anxiety and depression.Methods A total of 60 adolescents with anxiety and depression who were admitted to the Third Peo-ple's Hospital of Yichun from March 2022 to February 2023 were selected as the study subjects,and they were divided into the control group(30 cases)and the intervention group(30 cases)by random number table method.The control group re-ceived routine psychiatric care,while the intervention group received mindfulness-based cognitive intervention.The medi-cation compliance,emotional state,psychological stress state and quality of life of the two groups were compared,and the scores of Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)of the two groups were compared.Results The medication compliance rate in the intervention group was higher than that in the control group,with statistically signifi-cant difference(P＜0.05).After 4 weeks of intervention,the HAMA scores and HAMD scores were lower than those before intervention,and above scores in the intervention group were lower than those in the control group,with statistically signifi-cant differences(P＜0.05).After 4 weeks of intervention,negative coping score of the trait coping style questionnaire(TCSQ)in the intervention group was lower than that before intervention,and the positive coping score was higher than that before intervention.The negative coping score in the intervention group was lower than that in the control group,and the positive coping score was higher than that in the control group,with statistically significant differences(P＜0.05).After 4 weeks of intervention,all the scores of quality of life in the intervention group were higher than those before intervention,and the scores of the intervention group were higher than those of the control group after 4 weeks of intervention,with statistically significant differences(P＜0.05).Conclusion Mindfulness-based cognitive intervention can significantly improve the symptoms of adolescents with anxiety and depression and regulate their psychological stress while improving quality of life.
Objective To analyze the mediating effect of sense of coherence on family hardiness and postpartum depression in parturients.Methods A cross-sectional survey method was used to select 148 puerpera who were treated in Panyu Fifth People's Hospital of Guangzhou City from June to December 2022 as the research objects.The sense of coherence-13(SOC-13),family hardiness index(FHI)and Edinburgh postnatal depression scale(EPDS)were used to conduct a question-naire survey,and the mediating effect model was constructed and tested.Results The scores of SOC-13,FHI and EPDS were(70.85±8.75)points,(50.78±9.74)points,and(7.07±2.70)points,respectively,and 24(16.2％)of them were posi-tive for depression.SOC-13 was positively correlated with responsibility dimension,control dimension,challenge dimension and total score of FHI(r=0.404-0.551,P＜0.01),and was negatively correlated with EPDS(r=-0.547,P＜0.0 1).SOC-13 partially mediated the relationship between FHI and EPDS,accounting for 18.7％of the total effect.Conclusion The inci-dence of postpartum depression in parturients is high,but they have good sense of coherence and family hardiness.Sense of coherence plays a partial mediating effect between family hardiness and postpartum depression in parturients.
Objective To explore the application effect of enhanced recovery after surgery nursing in the perioperative period of precise resection of liver cancer.Methods A total of 60 patients with liver cancer admitted to Jiujiang NO.1 People's Hospital from January 2021 to December 2022 were selected as the research objects,and they were divided into control group(30 cases)and observation group(30 cases)according to the random number table method.The control group was given routine nursing measures,and the observation group was given enhanced recovery after surgery nursing on the basis of the control group.The first exhaust time,first ambulation time,hospitalization time,incidence of complications,nursing satis-faction,and quality of life before and after surgery were compared between the two groups.Results The first exhaust time,first ambulation time and hospitalization time of the observation group were shorter than those of the control group,and the nursing satisfaction score of the observation group was higher than that of the control group,and the differences were statisti-cally significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).After operation,the quality of life of the two groups were better than those before operation,and the quality of life of the observation group was better than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion The application of enhanced recovery after surgery nursing in the perioperative period of precise resection of liver cancer can effectively promote the postoperative rehabilitation of patients,reduce the incidence of postoperative complications,improve the satisfaction of patients with nursing,and im-prove the quality of life of patients after surgery.
Objective To explore the application effect of social skill training combined with total course management in patients with schizophrenia and its influence on social function.Methods A total of 80 patients with schizophrenia who re-ceived treatment in Jiangxi Province Veterans Special Care Hospital from April 2019 to April 2021 were selected as the re-search objects,and they were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group received drug therapy and traditional nursing.On the basis of control group,the observation group received social skill training combined with total course management.Psychiatric symptoms and social adaptability before and after intervention,and medication compliance and satisfaction after intervention were compared be-tween the two groups.Results After intervention,the scores of all indexes and total scores of psychiatric symptoms in two groups were lower than those before intervention,and the scores of observation group were lower than those of control group,the differences were statistically significant(P＜0.05).After intervention,scores of all dimensions of social adaptability in two groups were lower than those before intervention,and scores in observation group were lower than those of control group,the differences were statistically significant(P＜0.05).Medication compliance and total satisfaction in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Social skill training combined with total course management can improve the psychiatric symptoms,social adaptability function,compliance and satisfaction of patients with schizophrenia.
Objective To investigate the clinical effect of Xihuang Pills on cancer fever in patients with advanced malignant tumor.Methods From January 2019 to December 2020,80 patients with advanced malignant tumor with fever were selected as the research objects,and they were divided into observation group(40 cases)and control group(40 cases)according to random number table method.The control group was treated with Lofenac Sodium Sustained Release Tablets,and the obser-vation group was treated with Xihuang Pills on the basis of the control group.The clinical outcomes,Karnofsky performance score(KPS),the World Health Organization Quality of Life-BREF(WHOQOL-BREF)and adverse reactions were compared between the two groups.Results The total effective rate of fever reduction in observation group was higher than that in con-trol group after treatment,the difference was statistically significant(P＜0.05).KPS and WHOQOL-BREF scores in the ob-servation group after treatment were higher than those before treatment,and the differences were statistically significant(P＜0.05).The scores of KPS and WHOQOL-BREF in control group after treatment were higher than those before treatment,and the differences were statistically significant(P＜0.05).There were no significant differences in KPS and WHOQOL-BREF scores between the two groups before treatment(P＞0.05).After treatment,KPS and WHOQOL-BREF scores in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).There was no sig-nificant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The application of Xihuang Pills on cancer fever in patients with advanced malignant tumor can achieve definite antipyretic effect,functional status and quality of life are improved,and adverse reactions are less,and it has good safety.
Objective To explore the effect of class teaching mode application of case-based learning(CBL)and prob-lem-based learning(PBL)in pediatric teaching in colleges and universities.Methods The methods adopted include that se-nior students from Class 7,2019 undergraduate classes in the department of Clinical Medicine in Weifang Medical Univer-sity were selected as the study subjects,from September 1,2022 to February 25,2023.The group before the reform adopted CBL teaching methods,and the group after the reform adopted the CBL+PBL teaching methods so as to compare the theo-retical scores,practical skills,total scores,ability improvement and satisfaction of the two groups.Results The results showed that the theoretical scores,practical skills scores and total scores of the group after the reform were higher than those of the group before the reform,with statistically significant differences(P＜0.01).The questionnaire results show that 94.2％of students after the reform were satisfied with this teaching mode,more than 94％of students agreed that it was helpful to improve learning efficiency,stimulating independent thinking,theoretical knowledge consolidation,self-regulated learning ability,clinical problem analysis,diagnosis and treatment ability,team cooperation and language expression.Conclusion The boring cramming teaching mode can be replaced by the methods of PBL based on CBL,which would fully mobilize the initiative and enthusiasm of students in learning,improve students'ability of self-regulated learning and self-direct-ed learning,as well as establishing students'evidence-based thinking,improving their clinical ability,with which col-lege students are highly satisfied.
Objective To analyze the predictive value of carotid artery ultrasound for onset risk of coronary heart disease(CHD).Methods The clinical data of 60 patients who were suspected diagnosis of CHD and admitted to the Third People's Hospital of Pingxiang City from January 2021 to December 2022 were retrospectively analyzed.All patients were examined with carotid artery ultrasound and coronary angiography(CAG).With CAG as the golden standard,the patients were divided into CHD group(n=45)and non-CHD group(n=15).The common carotid intima-media thickness(IMTc)at 1 cm from the carotid artery bifurcation,intima-media thickness(IMTs)at carotid artery bifurcation,and plaque formation were evaluated.The predictive value of carotid artery ultrasound for CHD was analyzed.Results IMTc,IMTs,and plaque formation in the non-CHD group were smaller/less than those in the CHD group,the differences were statistically significant(P＜0.05).The AUC value of plaque formation for predicting CHD(0.889)was higher than that of IMTc or IMTs.Its sensitivity and specificity for predicting CHD were 84.44％and 93.33％,respectively.Conclusion Carotid artery ultrasound is practical in predicting the risk of CHD,and can be used as an important auxiliary method for diagnosing CHD.
Objective To investigate the application of Sevoflurane general anesthesia in the oral treatment of children with dental phobia and its effect on the diversity of oral flora.Methods A total of 60 children with dental phobia admitted to Jiangxi Provincial Children's Hospital from May 2021 to September 2022 were selected as the research objects.According to the random number table method,they were divided into control group(30 cases)and experimental group(30 cases).The control group was treated with Midazolam anesthesia,and the experimental group was treated with Sevoflurane anesthesia.The anesthetic effect,the incidence of adverse reactions,the number of bands in denaturing gradient gel electrophoresis(DGGE)of saliva samples,and the heart rate,respiratory rate,mean arterial pressure,and blood oxygen saturation before and after anesthesia were compared between the two groups.Results The disappearance time of consciousness reaction,the dis-appearance time of eyelash reflex,the disappearance time of pain reaction,and the time of consciousness recovery in the ex-perimental group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The number of bands in the saliva DGGE electrophoresis pattern of the experimental group was higher than that of the control group,and the difference was statistically significant(P＜0.05).There were no sta-tistically significant differences in heart rate,respiratory rate,mean arterial pressure,and blood oxygen saturation between the two groups before anesthesia(P＞0.05).After anesthesia,the heart rate,respiratory rate,and mean arterial pressure of the experimental group were lower than those of the control group,and the blood oxygen saturation was higher than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion Sevoflurane general anesthesia can significantly improve the anesthetic effect of children with dental phobia and enrich the diversity of oral flora.
Objective To explore the clinical effect of laparoscopic descend fixation of cryptorchidism on high cryp-torchidism in children.Methods Forty children with high cryptorchidism admitted to the Puning People's Hospital from April 2021 to April 2022 were selected as the study objects,and they were divided into laparoscopic group(20 cases)and open group(20 cases)according to random number table method.The children in the laparoscopic group were treated with laparoscopic descendopexy of cryptorchidism,and the open group was treated with open operation descendopexy of testis.The clinical efficacy,testicular development,surgical indexes,sex hormones(epidermal growth factor[EGF],testosterone[T],5 α-dihydrotestosterone[5 α-DHT],estradiol[E2],follicle-stimulating hormone[FSH])and complications were com-pared between the two groups.Results The total effective rate of laparoscopic group was higher than that of open group,and the difference was statistically significant(P＜0.05).The rates of testicular atrophy and abnormal blood supply in laparo-scopic group were lower than those in open group,and the differences were statistically significant(P＜0.05).The intraoper-ative blood loss in the laparoscopic group was lower than that in the open group,the visual analogue scale(VAS)score was lower than that in the open group,and the time of getting out of bed and staying in hospital were shorter than that in the open group,with statistical significances(P＜0.05),while there was no statistical significance in the operation time be-tween the two groups(P＞0.05).The levels of EGF,T,5 α-DHT and FSH in the laparoscopic group after treatment were higher than those in the open group,and the levels of E2 were lower than those in the open group,with statistical significances(P＜0.05).There was no significant difference in the total incidence of postoperative complications between the two groups(P＞0.05).Conclusion Laparoscopic descent and fix-ation of high cryptorchidism in children has better efficacy than open surgery,which can reduce the occurrence of testicular retraction and atrophy,reduce surgical trauma and blood loss,relieve pain and promote rapid recovery of children.
