2004年版WHO<肺、胸膜、胸腺和心脏肿瘤病理学和遗传学分类>中关于肺癌的部分增加了肺泡腔隙充填型周围型鳞状细胞癌(alveolar space-filling type of peripheral)的内容[1,2].其特点为肿瘤细胞充填肺泡腔隙,没有破坏肺泡框架结构.

OBJECTIVE:To explore multi-drug resistance (MDR) of bladder cancer for the intravesical instillation.METHODS:Using immunohistochemical staining, in 44-case human bladder cancer cells, the expressions of P-glycoprotein (P-gp), glutathione S-transferase (GST-pi) and topoisomerase (TOPO-II), were detected to find out the resistance to drugs.RESULTS:P-gp had a higher expression in 54.5% cases. GST-pi had no or a lower expression in 65.9% cases. TOPO-II had a higher expression in 29.5% but a lower expression in 65.9% cases.CONCLUSION:Detecting the factors of MDR in bladder cancer cells could help to choose drugs for intravesical chemotherapy.

肿瘤细胞产生耐药性是多方面的,其中以多药耐药性(MDR)最为常见,P糖蛋白(P-GP)、谷胱甘肽-S-转移酶-π(GST-π)及拓扑异构酶(TOPOⅡ)是恶性肿瘤产生MDR的物质基础[1～3].2001年1月至2002年9月,我院应用免疫组化方法检测了68例胃癌患者的癌组织P-GP、GST-π、TOPOⅡ,以探讨三者在胃癌组织中的表达和临床意义.

患者男,41岁.上腹部不适4年,加重2个月.因消瘦、发热及黑便于2001年11月27日入院.体检:其他脏器无明显异常.钡餐示:十二指肠、空肠处见多个散在的大小不等的钡剂龛影,边缘整齐,直径1～5 cm,范围分布在1～3组小肠,部分肠壁稍硬,蠕动不规律.手术所见:十二指肠球前壁有一约6 cm×5 cm包块,空肠散在大小不等的肿块,呈凹陷性,肠系膜淋巴结肿大.随访结果:术后半年因肝功能衰竭,大量腹水死亡.