Objective To assess the effect and safety of Huosha oral liquid in the treatment of painful abdominal mass. Methods 120 patients were divided randomly into two groups, the treatment group (65 cases) were treated with Huosha oral liquid, the control group (55 cases) with Huoxiang Zhengqi oral liquid for 3 days. Results There was a significant difference in the integrals of symptoms before and after treatment in treatment group (P0.01),there was a significant difference in efficacy between two group (P0.01). Conclusion Huosha oral liquid has favourable therapeutic effect and safety in treating painful abdominal mass.