目的 探讨藿砂口服液对腹泻型肠易激综合征(IBS-D)大鼠肠动力的调节作用.方法 将100只Wistar大鼠按随机数字表法分空白组、模型组、低剂量组、中剂量组、高剂量组,每组20只.模型组每日用0.1 g/mL常温大黄水煎剂2 mL灌胃加束缚四肢及躯体持续2 h,连续6 d,建立IBS-D模型大鼠;低、中、高剂量组在造模同时每日分别灌服0.091、0.182、0.364 g/kg藿砂口服液,连续6 d;空白组不予造模及药物干预.观察各组大鼠的一般情况;干预后第1天,各组分别取10只大鼠取血后采用氧化还原法检测血清一氧化氮(NO),ELISA法检测血清5-羟色胺(5-HT)含量;干预后第2天,通过炭末推进试验计算小肠推进率;干预后第3天,通过结肠转运试验观察玻璃小球排出时间.结果 与空白组比较,模型组腹泻、消瘦明显,精神较差,活动量减少;与模型组比较,低、中、高剂量组腹泻改善,消瘦不明显,精神状态及活动量正常;与模型组比较,低、中、高剂量组大鼠血清NO含量明显提高,5-HT含量明显降低,小肠推进率减少,玻璃小球排出时间延长(P均<0.05);低、中、高剂量组各指标组间比较无统计学意义(P>0.05).结论 藿砂口服液具有调节血清NO、5-TH的含量,减缓小肠过快推进运动,降低结肠转运速度,调节IBS-D大鼠肠动力紊乱的功能.

目的 探讨藿砂口服液对腹泻型肠易激综合征(D-IBS)患者5-HT、IL-1β、IL-10的影响.方法 随机选取30例寒湿型D-IBS患者做为治疗组,随机选择同期30例健康体检者做为健康组,治疗组予藿砂口服液治疗,共治疗28 d.观察2组血5-HT及肠黏膜5-HT、IL-1β、IL-10指标的变化.结果 与健康组比较,治疗组治疗前血5-HT及肠黏膜5-HT、IL-1β明显升高(P＜0.05);与治疗前比较,治疗组治疗后血5-HT及肠黏膜5-HT、IL-1β明显降低(P＜0.05).结论 藿砂口服液可以降低腹泻型D-IBS患者血5-HT及肠5-HT、IL-1β水平.

培养可以适应临床快速发展需要的医学人才，是临床医学教学的最终目的。而只有提升医学人才的创新思维、创新能力，才能满足人们对健康和医疗服务水平不断增长的需要。因此，对于加强创新型医学人才培养的重要性不言而喻，通过日常临床教学过程中的发现，只有在日常的临床教学中不断增强带教老师整体创新教学理念，调动学生的临床学习创新性，辅以生活的临床实践活动平台及成熟的临床教学考评体系才能保证以临床为导向的创新型医学人才培养的教学工作有序稳定有力的开展。

培养适应临床需要的实用型合格医学人才，是临床医学教学的根本目的。因此对于加强医学生临床实际技能的培养的重要性不言而喻，通过发现实际工作中存在的问题，不断完善临床技能理论课程体系，培养优良的临床技能师资队伍，创建校内外临床技能培训中心，并构建临床理论与实践综合考评体系，以保障临床医学生临床技能培养的顺利进行。

目的 探讨长期抗病毒治疗对乙肝肝硬化患者疾病转归的影响.方法 对2008～2011年多次于我院住院治疗符合CTP B级诊断的26例乙肝后肝硬化长期随访并进行回顾性分析,随访时间30个月～7年,平均58个月,收集治疗前后右肝斜径、门静脉宽度、CTP评分、ALT、血清白蛋白、INR、住院次数及平均住院时间的数据,进行统计学分析.结果 治疗后患者右肝斜径、门静脉宽度、CTP评分、ALT、血清白蛋白、INR、住院次数及平均住院时间均比治疗前有明显改善,且差异有统计学意义.结论 长期的抗病毒治疗,对CTP B级的肝硬化患者,是一个安全有效的治疗手段.但用药期间仍需注意原发性肝癌的风险.

目的 探讨黄疸患者血清腺苷脱氨酶ADA变化及血清ADA对鉴别黄疸类型、中医辨证的临床意义. 方法 将64例黄疸患者作为研究对象,其中肝细胞性黄疸组(A组)34例,阻塞性黄疸组(B组)34例,中医辨证分为湿重于热证、热重于湿证、胆腑郁热证、疫毒炽盛证.比较2组血清ADA值、ADA阳性率、胆红素指标以及不同证型间血清ADA情况. 结果 A组血清ADA值高于B组,A组血清ADA阳性率为88.24％,高于B组的26.47％,P均＜0.01.湿重于热证、热重于湿证的黄疸患者血清ADA值均高于胆腑郁热证的黄疸患者血清A-DA值,P均＜0.05. 结论 不同类型及不同中医证型的黄疸患者血清ADA值、ADA阳性率有明显差异,提示血清ADA可能对鉴别黄疸类型及黄疸客观化辨证具有参考意义.

目的:研究藿砂口服液对慢性非萎缩性胃炎患者胃电节律的影响.方法:选择门诊中医诊断为痞满证、西医诊断为慢性非萎缩性胃炎患者66例,采用随机区组分组法分为治疗组(服用霍砂口服液)和对照组(服用安慰剂),疗程2周,观察并记录两组治疗前后胃电节律的变化,统计比较治疗前后差异.结果:治疗组患者胃电节律治疗前后变化有显著性差异(P＜0.05),对照组患者治疗前后胃电节律无明显变化,治疗后(除胃窦主频)组间比较P＜0.05.结论:藿砂口服液对慢性非萎缩性胃炎的治疗作用和胃电节律变化具有相关性.

Objective To observe the antidiarrheal effect of Huosha oral liquid on model mice.Methods Mice were given rhubarb infusing by stomach perfusion to establish the model of diarrhea.Using Carbo Medicinalis as indicator,the first time of defecation,the defecation frequency and the integral of excrement character as indexes,the antidiarrheal effect of different doses of Huosha oral liquid was observed by pigment flow method.Results The first time of defecation was markedly put off,the defecation frequency was reduced,and the excrement character was improved in Huosha oral liquid groups with different doses.There was a positive correlation between the dose of Huosha oral liquid and the decrease of defecation frequency.Conclusion Huosha oral liquid has antidiarrheal effect,and the intensity of antidiarrheal effect is dependent on the drug dose.

<正>肠易激综合征(irritable bowel syndrome,IBS)是一种以腹痛或腹部不适伴排便习惯改变为特征的功能性肠病,病因和发病机制尚不十分清楚,病理生理学基础主要是胃肠动力和内脏感知异常[1]。治疗上以个体化为主,尚无明确规范的治疗方案。藿砂合剂

Objective To assess the effect and safety of Huosha oral liquid in the treatment of painful abdominal mass. Methods 120 patients were divided randomly into two groups, the treatment group (65 cases) were treated with Huosha oral liquid, the control group (55 cases) with Huoxiang Zhengqi oral liquid for 3 days. Results There was a significant difference in the integrals of symptoms before and after treatment in treatment group (P0.01),there was a significant difference in efficacy between two group (P0.01). Conclusion Huosha oral liquid has favourable therapeutic effect and safety in treating painful abdominal mass.

Objective The aim of t his study was to evaluate the securit a nd the efficacy of electrotomy therapy f or sporadic colorectal adenoma.Method s Among patients with colorectal poly ps diagnosed with the colonoscope,those were chosen who had sporadic colorectal adenomata through pathologic inspection and were hospitalized in order to excis e adenomata with electrotomy.Results All fifty-four adenomata were excised with electrotomy.The adenomata distribu ted mainly over left-side colon(47/54).B leeding occurred in five patients during the operation(5/26).None had delayed ble eding and perforation after endoscopic t herapy.Through pathologic inspection,one adenoma was malignant in all retrievabl e adenomata(1/26).Two patients had palin dromic adenomata after one year(2/26). Conclusion Sporadic colorectal adeno ma treated by electrotomy therapy is eff ective with few complications.It should be considered a first choice therapy for sporadic colorectal adenoma.