This paper is aimed to assess the effects of red blood cell (RBC) transfusion on clinical outcomes in cardiac surgery. Trials were identified by computer searches of the Pubmed, MEDLINE, Cochrane Library (Issue 10, 2012), from January 1980 to October 2012. References in identified trials and review articles were checked and experts contacted to identify any additional trials. The homogeneous randomized controlled trials (RCTs) were analyzed with RevMan 5.1 software. Five trials involving a total of 1,203 patients were identified. The results of meta-analyses showed that restrictive transfusion strategies reduced the risk of receiving a RBC transfusion (MD = - 1.46, 95% CI -1.18(-) -1.1) and the volume of RBCs transfusion (RR = 0.69, 95% CI 0.53-0.89). No significant difference was noted between the two strategies in terms of mortality, adverse events and hospital or intensive care length of stay. Based on the results mentioned above, one can draw a conclusion that restrictive transfusion strategies reduced the risk of receiving RBC transfusion and the volume of RBCs transfused. Restrictive transfusion strategies did not appear to impact on the rate of adverse events and hospital or intensive care length of stay, compared to liberal transfusion strategies.

Objective To evaluate the effect of ulinastatin on oxygen free radical and inflammatory factors during one lung ventilation.Methods According to the Cochrane Handbook,we searched database like Cochrane Library,OVID,Pubmed to collect related randomized controlled trails(RCT).The quality of the included studies was evaluated and was analyzed by meta-analysis with RevMan 5.0.Results Seven RCTs involving 242 participants were included.Meta-analysis results: Ulinastatin decrease the concentration of IL-6,IL-8,TNF-a,MDA and increase the SOD level in patients`blood.Conclusion Ulinastatin shows protection of lung function by decreasing the concentration of inflammatory factory in patients`blood during one lung ventilation.