目的:探讨辛伐他汀治疗冠心病的效果及机制。方法:将收治的60例冠心病患者分为治疗组和对照组,对照组采用心内科常规治疗,治疗组在对照组的基础上加用辛伐他汀治疗,比较两组患者的治疗效果、心血管不良事件的发生率及内皮功能的变化。结果:治疗组的总有效率为83.3%,显著高于对照组的66.7%(P<0.05)。治疗组血浆内皮素(ET)、一氧化氮(NO)的含量的改善显著高于对照组(P<0.05)。两组随访6～12个月,治疗组的心血管不良事件的发生率显著低于对照组(P<0.05)。结论:辛伐他汀可有效预防冠心病的不良心血管事件,可能与其改善血管的内皮功能有关。
Since the last years of twentieth century,formulations of drugs have been greatly changed.Consequently,for the protection of public health,bioequivalence has developed rapidly and has been considered to be the focus of many publications.This paper enunciates the international regulations and history of bioequivalence.It shows an outline of bioequivalence two one sided testing procedure.Some study designs and analysis methods commonly used in the testing for bioequivalence are also included,which are designed with two periods or designed with more than two periods.With the appearance and application of novel TOST base method,the evaluation ofbioequivalence will be more accurate.
Objective To establish a method for determining astragaloside Ⅳin Shenqi Mixture.Methods HPLC-ELSD was employed in the quantitative analysis of astragaloside Ⅳ.The separation was performed on Resterk C18 column(250 mm×4.6 mm,5 μm)with a mixture of acetonitrile-water(35:65)as the mobile phase.The flow rate was 1.0 mL/min.For ELSD,the temperature of drift tube for measurement was 100℃and carrier gas was 3 L/min.Results The linear range of astragaloside Ⅳwas 5.059 7-6.012 6 μg/mL(r=0.999 1),the average recovery was 99.73%and the relative standard deviation was 0.73%(n=9).Conclusion The method is simple,reliable,sensitive with good reproductivity for analysing the astragaloside Ⅳin Shenqi Mixture and control its quality.
OBJECTIVE:To establish a RP-HPLC method for the determination of Adenosine in Ganoderma capsule.METHODS:HPLC method was adopted with Diamonsil C18(150mm× 4.6mm,5μ m)at a temperature of 30℃.The mobile phase consisted of methanol-0.01mol· L-1 KDP solution(10∶ 90)at a flow rate of 0.8mL· min-1.A UV-detector at 260nm was used.RESULTS:The linear range of Adenosine was 0.081 4～ 2.036 0μ g(r=0.999 4).The average recovery was 99.37%(RSD=0.23%,n=6).CONCLUSION:The method is accurate,simple,rapid,and reliable,and suitable for the quality control of Ganoderma capsule.
