·AIM:To investigate the diagnostic value of the axial length/corneal radius of curvature(AL/CR)for myopia in children and adolescents. ·METHODS:PubMed,Embase,The Cochrane Library,CNKI,CBM,WanFang Data and VIP databases were searched to collect clinical research on the value of AL/CR in diagnosing myopia in children and adolescents,and the retrieval time was from establishment to September 30,2023.The QUADAS-2 tool was used to evaluate the quality of the extracted literature.A random-effects model was used to pool diagnostic test data,Meta-regression and subgroup analysis were performed to explore sources of heterogeneity. ·RESULTS:A total of 10 articles involving 19 872 study participants were included,and Meta-analysis showed that the pooled sensitivity of the AL/CR for the diagnosis of myopia in children and adolescents was 0.91[95％Cl(0.90-0.91)],the pooled specificity was 0.84[95％Cl(0.84-0.85)],and area under the SROC curve of 0.95[95％CI(0.93-0.96)]. ·CONCLUSION:The AL/CR is a good indicator of myopia in children and adolescents.

目的 系统评价中医外治法防控儿童青少年轻、中度近视进展的临床疗效.方法 检索2012年1月—2022年4月PubMed、Embase、Cochrane Library、中国知网、万方、维普、中国生物医学文献数据库中关于中医外治法防控儿童青少年轻、中度近视的随机对照试验(RCT),由2位研究者独立筛选文献.评价纳入研究的偏倚风险后,采用RevMan 5.4统计软件进行Meta分析.结果 共纳入13篇文献,1,595例(3,093只眼)6～18岁患者,其中试验组1,540只眼,对照组1,553只眼.使用中医外治法防控儿童青少年轻、中度近视发展的试验组总体有效率优于阿托品滴眼液组[OR=5.160,95%CI(3.770,7.060),Z=10.250,P=0.000]和(复方)托吡卡胺滴眼液组[OR=4.320,95%CI(3.060,6.100),Z=8.310,P=0.000],在提高患者的裸眼视力[MD=0.070,95%CI(0.050,0.090),Z=6.230,P=0.000]、控制屈光度进展[MD= 0.360,95%CI(0.290,0.440),Z=9.100,P=0.000]方面也优于使用抗胆碱能类滴眼液的对照组.结论 中医外治法在一定程度上可延缓儿童青少年轻、中度近视进展,对屈光参数有改善作用,一般无明显不良反应.但纳入文献的研究方法不统一,未来还需多中心、大样本、高质量的RCT进一步验证.

Purpose: To investigate the clinical efficacy of pranoprofen eye drops when combined with emedastinedifumarate eye drops for the treatment of children with allergic conjunctivitis.Methods: A total of 96 children with allergic conjunctivitis admitted to Eye Hospital, China Academy of Chinese Medical Sciences from January 2020 to 2022 were enrolled in this study. They were divided into study group (treated with both pranoprofen eye drops and emedastine difumarate eye drops), and control group (treated with emedastine difumarate eye drops alone), with 48 children in each group. The control group was given emedastine fumarate eye drops 1 drop twice a day. The study group was given pranoprofen eye drops 2 drops 4 times a day in addition to the treatment administered to control group. Patients in both groups were observed and compared after one week of treatment. Efficacy, incidence of adverse reactions, symptom scores, inflammatory factors, tear film stability indicators and immune function indicators were assessed and recorded.Results: Prior to treatment, there was no significant difference in symptom score, inflammatory factors, tear film stability indicators and immune function indicators between study and control groups. Although the above indicators improved in both groups after treatment, the study group showed significantly greater improvement than control group (p < 0.05). Overall clinical response rate in the study group (95.83 %) was higher than in the control group (77.08 %), while the incidence of adverse reaction in the study group (6.25 %) was lower than that of control group (27.08 %, p < 0.05).Conclusion: Pranoprofen eye drops, when combined with emedastine difumarate eye drops for treatment of children with allergic conjunctivitis, is more effective than the use of emedastine difumarate eye drops alone. However, further clinical trials are required to validate the findings of this study prior to adoption of the combination treatment in clinical practice.

视觉质量取决于眼睛的屈光状态、晶状体的调节功能、眼球聚散功能、视觉信息传导功能和大脑视中枢整合功能[1].调节痉挛、散开不足、调节灵敏度下降等即可导致非器质性视力下降(nonorganic visual loss,NOVL),又称为功能性视力下降或心因性视力下降,特指患者存在主观的视觉传入功能障碍,但全面地客观检查未显示能够解释功能障碍的结构和功能异常[2].可单眼发病,亦可双眼发病;可单独存在,也可与器质性病变同时存在.近3年,受社会环境影响,视频终端设备的过度使用、户外活动时间减少、不良姿势用眼时间延长等,均加剧了用眼负荷,NOVL的发病率也逐年攀升,应引起眼科医生的重视.现报道1例双眼NOVL的病例,以飨同道.

风牵偏视是眼科常见疑难病,以眼珠突然偏斜,转动受限,视一为二为临床特征,类似于现代医学中的后天性、周围性麻痹性斜视.西医治疗方法包括积极治疗原发病,对症采用糖皮质激素疗法、注射肉毒杆菌毒素、营养神经及手术等,对一些患者有较好疗效,但仍有复发者.中医学认为,此病多由机体正气亏虚,风邪乘机侵袭所致.庄曾渊研究员在总结历代医家对该病认识的基础上,结合自身的从医经验,认为该病主要病因大多归咎于风,因此治疗上偏重于疏风,并重视理血药的应用,构成了从风论治,重视理血的组方用药框架,达到局部与整体结合,标本兼治的目的,在临床上取得了良好疗效.本文旨在总结庄曾渊辨证治疗风牵偏视的临床经验,以期为同行提供思路.

近视防控是一个世界难题,我国作为近视大国,儿童青少年近视的防控已经上升到了国家战略.中医对近视早有认识,称之为"能近怯远",并形成了一套独特的思想理论体系,其中最具特色的为"治未病"思想.目前对于防控近视,西医的方法有一定的局限性,而中医对于近视的防控方法较多,尤其是中医外治法,主要包括中药外用、针刺、灸疗和推拿4大类,中药外用主要包括中药热敷、熏洗及离子导入;针刺主要穴位有攒竹、四白、太阳、睛明等穴;灸法主要有艾灸和雷火灸.上述方法可以单独使用,也可以联合治疗,具有操作简便、临床疗效明显、经济实用的优势.本文综述了近十年中医外治疗法在防控青少年近视的临床应用进展,以期为临床应用提供方向和方法,尤其研发能在家进行的、有效的中医外治疗法,将会对防控近视起到积极作用.

目的 本研究基于网络药理学及生物信息学探讨启明丸控制近视进展的作用机制.方法 通过TCMSP、TCMID数据库检索启明丸中中药的有效成分,并通过SwissTarget-Prediction预测有效成分的靶点;利用Genecards、Drugbank、TTD、OMIM、DisGeNET、Phar-mGKB数据库,收集近视的靶点;基于药物与疾病的共同靶点,通过Cytoscape3.7.1软件构建药物有效成分-靶点网络;利用String平台构建交集靶点蛋白互作网络(PPI);通过DAVID进行GO功能和KEGG通路富集分析.结果 共筛选出启明丸活性成分228个,有效作用靶点197个,药物疾病共同作用靶点80个.PPI网络发现,MMP2、MMP9、STAT3、IGF1R、EGFR等可能是启明丸控制近视进展的关键靶点.GO功能富集发现了220个条目,KEGG通路富集分析共筛选出作用通路76条.结论 启明丸可以作用于MMP2、MMP9、STAT3、IGF1R、EGFR等关键靶点,可能通过PI3K-Akt信号通路、雌激素信号通路、甲状腺激素信号通路、HIF-1信号通路等重要通路,影响巩膜重塑、视锥细胞分化和视蛋白合成等过程发挥控制近视进展的作用.

目的 观察目舒丸对兔眼睫状体平滑肌细胞内钙依赖性及非钙依赖性舒缩信号传导的影响.方法 分离提取原代新西兰大白兔眼睫状体平滑肌细胞均匀接种于孔板中,随机选出27个接种孔,并随机分为9组,每组3个孔,分别命名为A组～Ⅰ组.其中A～G组分别予8、4、2、1、0.5、0.25、0.125 mg/mL7个不同浓度目舒丸进行干预,在不同干预时间点观察目舒丸对兔眼睫状体平滑肌细胞舒缩作用,确定最佳干预时间及最佳药物浓度.H组予0.5 mmol/L氯化乙酰胆碱培养,Ⅰ组先予1.0 mg/mL目舒丸溶液培养,再予相同浓度的氯化乙酰胆培养,检测2组细胞内蛋白激酶C(PKC)、同源基因家族成员A(RhoA)的基因表达,观察目舒丸对睫状体平滑肌细胞内与舒缩有关的钙依赖性及非钙依赖性信号传导的影响.结果 (1)细胞直径:与给药前比较,A组给药后所有时间点细胞直径均缩短;C组给药后4、10 min细胞直径均伸长;D组给药后1、2、4、10 min细胞直径均伸长;E组给药后2、4、10 min细胞直径均伸长,以上比较均有统计学意义(P＜0.05).组间比较,与A组给药后各时间点比较,B～G组细胞直径均伸长;与B组给药后10 min比较,E组细胞直径缩短;与C组给药后0.5 min比较,E组细胞直径缩短;与C组给药后1 min比较,D、G组细胞直径伸长;与D给药后10 min比较,E组细胞直径伸长;与E组给药后0.5 min比较,F组细胞直径伸长;与F组给药后2 min比较,G组细胞直径伸长,以上差异均有统计学意义(P＜0.05).(2)PKC及RhoA的表达:与H组比较,Ⅰ组的PKC及RhoA表达量降低,差异均有统计学意义(tPKC=-3.566,P=0.023;tRhoA=-8.895,P=0.001).结论 目舒丸能影响睫状肌舒缩,并呈一定的时间依赖关系,其中1.0 mg/mL的浓度作用最强,可能与干预兔眼睫状体平滑肌细胞钙依赖性及非钙依赖性信号因子有关.

目的 系统评价耳穴压丸干预儿童青少年近视的效果,为近视防控提供依据.方法 计算机检索数据库并筛选耳穴压丸治疗儿童青少年近视的临床随机对照试验研究,检索时限为建库至2020年12月.由2位研究者独立筛选文献,评价纳入研究的偏倚风险,提取资料后采用RevMan 5.3软件进行Meta分析.结果 共纳入21篇文献,共计患者2450例(3855只眼),其中耳穴压丸组1995只眼,常规治疗组1860只眼.经Meta分析后结果显示耳穴压丸疗法干预儿童青少年近视的总有效率高于常规治疗,具有统计学意义[OR=2.85,95％CI(2.39,3.41),Z=11.62,P＜0.01].耳穴压丸疗效优于非睫状肌麻痹剂[OR=2.04,95％CI(1.57,2.46),Z=5.37,P＜0.01]和睫状肌麻痹剂[OR=3.80,95％CI(2.96,4.87),Z=10.50,P＜0.01],差异均有统计学意义.在视力、屈光度方面耳穴压丸疗法优于常规治疗.同时耳穴压丸疗法能延缓眼轴增长、降低眼内压及前房深度,对临床症状如视物模糊、异物感、酸胀不适、干涩、流泪方面也均有改善作用.结论 耳穴压丸疗法干预儿童青少年近视疗效显著,且操作简便、安全,患儿依从性好,值得进一步推广.但目前研究质量整体偏低,证据强度不足,因此有必要对其进行大样本、多中心的高质量临床研究,为推广儿童青少年的近视防控提供依据.

五轮学说是中医眼科学的重要基础理论之一,它与五脏生理、病理有一定的联系,系历代中医学家用以解释眼的组织结构和生理、病理现象的一种独特的理论,是观眼识证的重要依据,在临床上应用广泛.但是,目前很少有对这一学说形成的理论基础和思维模式的研究.笔者查阅了五轮学说的相关文献,探寻古医家创建这一学说的哲学思维,试图从认知语言学隐喻的角度进行分析,针对这一特定历史条件下整体观的理想体现,运用隐喻理论解读和认识这一系统模型,并从这一学说的临床应用及局限性方面做简要探讨,从而更好的理解"五轮-五脏"配属关系.

目的 客观评价视疲劳患者眼部各调节参数的变化,研究目舒丸对视疲劳患者眼部异常调节参数的影响,为临床用药提供客观依据和指导.方法 纳入2009年1月—2009年10月符合诊断标准的单纯屈光不正(对照组)患者21例(42只眼),视疲劳(治疗组)患者56例(112只眼),将治疗组患者随机分为治疗1组和治疗2组,各28例(56只眼).治疗1组予七叶洋地黄双苷滴眼液点眼;治疗2组在治疗1组基础上加目舒丸口服.对照组不予处理.记录治疗组患者治疗前后的中医症状积分以及各组患者的眼部调节参数变化.结果 (1)症状积分:治疗2组治疗前后积分差值与治疗1组比较,差异有统计学意义(t=5.564,P=0.000);治疗前后比较,治疗1组(t=3.472,P=0.001)、治疗2组(t=4.536,P=0.000)均减少,差异有统计学意义.(2)临床疗效:治疗1组总有效率(71.43％)与治疗2组(92.86％)比较,差异有统计学意义(χ2=4.383,P=0.036).(3)调节幅度(RAMP、LAMP、OUAMP):治疗前,治疗组调节幅度均低于对照组,差异有统计学意义(tRAMP=6.493,tLAMP=7.722,tOUAMP=8.630,均P=0.000).治疗2组治疗前后RAMP、OUAMP增加值高于治疗1组,差异有统计学意义(tRAMP=4.761,tOUAMP=4.883,均P=0.000);治疗前后比较,治疗1组(tRAMP=4.218,tLAMP=6.278,tOUAMP=7.931,均P=0.000)、治疗2组(tRAMP=6.832,tLAMP=5.579,tOUAMP=3.991,均P=0.000)各调节幅度均增加,差异有统计学意义.(4)正、负相对调节(PRA、RA、AR):治疗前,治疗组与对照组比较,差异有统计学意义(tPRA=3.738,tRA=6.892,tAR=3.705,均P=0.000).治疗2组治疗前后PRA、RA增加值高于治疗1组,差异有统计学意义(tPRA=7.537,tRA=6.164,均P=0.000);治疗前后比较,治疗1组(tPRA=5.858,P=0.000;tRA=2.471,P=0.020)、治疗2组(tPRA=4.967,tRA=4.102,均P=0.000)PRA、RA均增加,差异有统计学意义.(5)单眼前加负镜片至模糊(RMB、LMB):治疗前,治疗组和对照组比较,差异有统计学意义(tRMB=6.067,tLMB=9.385,均P=0.000).治疗2组治疗前后RMB、LMB增加值均高于治疗1组,差异有统计学意义(tRMB=5.990,tLMB=6.499,均P=0.000);治疗前后比较,治疗1组(tRMB=13.000,tLMB=22.843,均P=0.000)、治疗2组(tRMB=15.222,tLMB=16.117,均P=0.000)RMB、LMB绝对值均增加,差异有统计学意义.(6)调节性集合/调节(AC/A)值:治疗前,治疗组计算性AC/A值低于对照组,差异有统计学意义(t=2.489,P=0.015).治疗2组治疗前后计算性AC/A增加值与治疗1组比较,差异无统计学意义(P>0.05);治疗前后比较,治疗1组(t=-4.385,P=0.000)、治疗2组(t=-6.914,P=0.000)计算性AC/A值均增加,差异有统计学意义.(7)调节灵敏度(AF)值:治疗前,治疗组AF值低于对照组,差异有统计学意义(t=6.991,P=0.000).治疗2组治疗前后AF增加值高于治疗1组,差异有统计学意义(t=5.605,P=0.000);治疗前后比较,治疗1组(t=15.821,P=0.000)、治疗2组(t=18.231,P=0.000)AF值均增加,差异有统计学意义.结论 目舒丸可改善视疲劳患者症状及调节功能.

目的 分析遗传因素及用眼行为与近视的相关性,探讨近视发生发展的危险因素,并提出防控建议.方法 通过"问卷星"发布《小学生用眼行为评定问卷》,了解引发小学生近视的相关危险因素,并使用SPSS17.0进行统计分析.结果 本次问卷共回收655份,全部为有效问卷.(1)单因素Logistic回归分析:父亲近视(OR低度=1.81,P=0.008;OR中度=2.22,P=0.000)、母亲近视(OR中度=2.00,P=0.003;OR高度=3.13,P=0.005),读写距离短(OR<1尺=2.03,P=0.000),读写时间长(OR 6～8 h=1.75,P=0.006;OR 8～10 h=3.99,P=0.000;OR>10 h=23.04,P=0.003),用眼习惯不良(躺着看书)(OR=1.81,P=0.035),读写环境不适宜(OR强光=5.37,P=0.009;OR暗光=4.46,P=0.004;OR车内=2.24,P=0.011),眼保健操不规范(OR=2.67,P=0.002),喜吃甜食(OR=2.34,P=0.045)、肉食(OR=1.64,P=0.018),偶尔吃蔬菜水果(OR=1.82,P=0.007),偶尔进行体育锻炼(OR=1.87,P=0.000),拥有电子设备(OR手机=1.84,P=0.000;OR ipad=1.65,P=0.007)、使用视频设备后自觉视力明显和轻微下降(OR=9.28、2.71,均P=0.000)等都是近视发生的可疑危险因素;周末平均每天户外活动>2 h是近视发生发展的保护因素(OR=0.11,P=0.049).(2)多因素Logistic回归分析:高年级、女性、母亲近视>-3.00 D、每天读写总时间>8 h、读写间隙偶尔休息、使用视频设备后自觉视力有下降、课间偶尔或从不到室外远眺、经常吃肉食等因素对近视发生的影响有统计学意义(OR>1,P<0.05).结论 导致近视发生发展的危险因素众多,在光学矫正或药物干预的同时配合行为控制在近视防控中至关重要.

目的 评价中医综合疗法对青少年单纯性近视进展的疗效. 方法 采用分层随机分组方法,将156例青少年单纯性近视患者287眼以近视屈光度数较高的一只眼为准分为＜-1.00DS(近视100度以下)及-1.00DS～-3.00DS(近视100 ～ 300度)两层,再随机分为治疗组和对照组.治疗组78例(141眼)、对照组78例(146眼).对照组给予健康宣教、常规配镜(＜-1.00DS者不配镜,-1.00DS～-3.00DS者配镜);治疗组在对照组基础上并予中医综合疗法,包括耳穴压豆、梅花针叩刺、穴位贴敷药物、脉冲电刺激,均每周2次,1个月为1个疗程,两组均观察3个疗程.干预前后比较不同层次两组患者裸眼视力,屈光度,角膜曲率,眼轴,正、负相对调节,调节幅度以及调节灵敏度,并比较进展情况. 结果 1)两组＜-1.00DS患者干预前后比较:与本组干预前比较,两组干预后裸眼视力均下降、屈光度均增加、眼轴均增长,治疗组调节灵敏度改善(P ＜0.05或P＜0.01);治疗组在干预后裸眼视力高于对照组,屈光度低于对照组(P ＜0.05或P＜0.01);治疗组进展33眼,进展率为75.00％;对照组进展42眼,进展率为93.33％,两组进展率差异有统计学意义(x2=4.343,P=0.037).2)两组-1.00DS ～-3.00DS患者干预前后比较:与本组干预前比较,两组干预后裸眼视力均下降、屈光度均增加、眼轴增长、调节灵敏度均改善(P＜0.01);治疗组干预后裸眼视力高于对照组,屈光度低于对照组(P＜0.05);治疗组进展56眼,进展率为57.73％;对照组进展73眼,进展率为72.27％,两组进展率差异有统计学意义(x2=4.611,P=0.032).结论 中医综合疗法能够在一定程度上缓解青少年单纯性近视进展程度,改善调节功能.

目的 分析屈光参差性弱视儿童短期屈光矫正治疗下视力提高效果情况及影响因素.方法 连续纳入来自于北京分布于8个区县的9家医院眼科屈光参差性弱视患儿104例,行裸眼视力、矫正视力、睫状肌麻痹下检影验光、眼位、眼球运动等检查;根据患者年龄及屈光状态予以处方配镜,戴镜3月后复查.分析不同年龄、不同弱视程度、不同屈光参差类型患儿短期屈光矫正后高度屈光不正眼最佳矫正视力提高情况及影响因素.结果 不同弱视程度及年龄各组间的疗效差异有统计学意义,而屈光参差类型中,近视组,远视组,散光组各组间的疗效差异无统计学意义,但优于近视合并散光组和远视合并散光组.结论 短期屈光矫正对儿童屈光参差性弱视的治疗有效.其疗效与弱视的程度、治疗年龄相关,而与患儿单纯近视、远视、散光屈光参差的类型无明显的相关性.

Objective:To analyze refractive status and visual acuity and its relationship to binocular visual function in children with anisometropic amblyopia.Methods:A total of 106 children (106 eyes) with anisometropic amblyopia were recruited from November 2015 to September 2016 in nine hospitals in Beijing.All children were divided into the following groups based on risk factors for anisometropia:hyperopia anisometropia (67 cases),myopia anisometropia (5 cases),astigmatism anisometropia (12 cases),hyperopia combined astigmatism anisometropia (20 cases) and myopia combined astigmatism anisometropia (2 cases).Visual acuity,uncorrected and best corrected visual acuity,refractive status,and distant/near stereoscopic vision were tested.Pearson's correlation was used to analyze the correlation between dioptric differences and UCVA/BCVA in high refractive errors eye and distant/near stereoscopic vision.The correlation between BCVA difference of the two eyes and distant/near stereoscopic vision were also calculated.One-way ANOVA compared BCVA in high myopic eye and distant/near stereoscopic vision between groups.Results:There was a correlation for the dioptric difference between UCVA and BCVA,distant stereoscopic vision,and random dot stereograms (RDS) stereoscopic vision in high refractive errors (all P＜0.05).There was a significant correlation between the difference in BCVA and distant stereoscopic vision and RDS stereoscopic vision (all P＜0.05).There was a statistically significant difference between the five groups for BCVA,distant stereoscopic vision and RDS stereoscopic vision (F=6.221,5.271,3.622,3.647,3.464,P＜0.05).Visual acuity for high refractive error eye in the myopia anisometropia group was best compared to the other four groups.The differences were statistically significant between each group (all P＜0.05).Distant stereoscopic vision in the hyperopia anisometropia group was best compared to the other four groups.The differences were statistically significant between each group,except hyperopia combined astigmatism anisometropia and myopia combined astigmatism anisometropia groups (all P＜0.05).RDS stereopsis in the myopia anisometropia group was best compared to the other four groups.The differences were statistically significant between each group (all P＜0.05).Conclusions:Visual acuity and stereoscopic vision are correlated to the dioptric difference.Stereoscopic vision is significantly correlated with the difference in BCVA.Stereoscopic damage is different in patients based on the type of anisometropia.

OBJECTIVE To evaluate the effect of ChuFeng YiSunTang and polyethylene glycol eye drops in management of dry eyes after cataract surgery. METHODS 104 patients(162 eyes) with dry eyes secondary to cataract surgery after one week who were treated in our hospital from February 2015 to December 2016 were randomly divided into trial group and control group . the trial group were treated with TCM concentrated granules and polyethylene glycol eye drops for four weeks, and control group was treated with only polyethylene glycol eye drops for four weeks. tear breakup time (BUT) schirmer I test (Sit) fluorescein staining (FL) and the subjective dry eye symptoms were graded before and after the treatment.RESULTS In the trial group (81 eyes), 44 eyes were markedly effective, 33 eyes were effective, 4 eyes were ineffective ,the total effective rate was 95.1% .in the comtrol group (81 eyes), 27 eyes were markedly effective, 42 eyes were effective, 12 eyes were ineffective ,the total effective rate was 85.2%(χ2=4.438,P=0.035). there was a statis-tically significant difference in tear breakup time (BUT) fluorescein staining (FL) and subjective dry eye symptoms after treatment in both trial group and control group (P>0.05). after treatment, tear breakup time (BUT) and subjective dry eye symptoms were better in the trial group than in the control group (P>0.05).there was no statistically significant difference in Schirmer I test(Sit) after treatment between trial group and control group. CONCLUSION Combined use of ChuFeng YiSunTang and polyethylene glycol eye drops could show better therapeutic effects than only use of polyethylene glycol eye drops on the dry eyes after cataract surgery.

China is one of the countries with high incidence of myopia in the world, which has attracted the attention of the national health care department. However, at present, there are still no convenient and effective methods to prevent and treat myopia in modern medicine at home and abroad. In this paper, the author compared the similarities and differences between modern medicine and traditional Chinese medicine in the prevention and treatment of myopia by searching relevant literature. The modern medical study of pathogenesis of myopia and the traditional Chinese medical perception of holistic theory of myopia, the idea of prevention-oriented eye care in modern medicine and the theory of treating before disease attacking in traditional Chinese medicine, the modern medicine and traditional Chinese medicine therapy and other aspects were analyzed mainly. Finally, the application value and orientation of Chinese medicine in the prevention and control of juvenile myopia were explored to find a new developing way. Key words: Juvenile myopia; Traditional Chinese medicine; Modern medicine; Prevention and control; Orientation; Innovation-driven development

Objective To analyze the prevalence of myopia among Chinese teenagers born between 1989 and 2014.Methods The epidemiology data were collected by searching the database of CNKI, Wanfang, VIP and PubMed. R 3.2.3 for Windows were used for meta-analysis.Results Eighteen studies were included in the meta-analysis and the pooled myopia prevalence was 38.37%(95%CI=29.06%~48.61%).The outcome of subgroup analysis showed that the prevalence was 29.77%, 40.00%, and 42.75%for northern China, southern China and western China, respectively. In the period from 2001~2007 the prevalence was 40.55%, and from 2008~2014, it was 36.23%.The prevalence was 22.53%, 51.07%and 65.44%among primary school, junior high school and senior high school students, respectively. For low, moderate and high myopia, the prevalence was 24.75%, 12.60%and 2.39%.Conclusions The prevalence of myopia among high school students is high, and the majority of it is low myopia.The prevention and treatment strategy of myopia is urgently needed.

"Preventive treatment of disease" is an important principle in TCM to prevent and treat diseases.Myopia is a main eye disease which damages the youth's visual acuity and its complication is one of the most important causes of blindness, so it becomes a public health issue. With the aid of ophthalmic microscopic detection approaches, "preventive treatment of disease" aims at the risk factors that cause myopia, which has extremely important significance for adolescent myopia prevention.

OBJECTIVE To explore the protective effect of TCM treatment on open-angle glaucoma and chronic angle-closure glaucoma patients whose intraocular pressure had been controlled.METHODS From 1997-2010 in our hospital,83(164 eyes) open-angle glaucoma and chronic angle-closure glaucoma cases whose IOP had been controlled were retrospectively analyzed.The patients were divided into traditional Chinese medicine treatment group and western medicine control group.Forty-nine patients(97 eyes) in TCM treatment group were given Chinese medicine,while 34 patients(67 eyes) in western medicine control group were only given western medicine.The two treatment groups were observed for 3 months,comparing the visual acuity and visual field.RESULTS 1.Visual field: in the TCM treatment group: 18 eyes were improved,75 eyes stable and 4 eyes worsened.In the western medicine control group: 3 eyes were improved,51 eyes stable and 13 eyes worsened.The difference was statistically significant(P0.05).2.visual acuity: 10 eyes were improved,84 eyes stable and 3 eye worsened in TCM treatment group.Six eyes were improved,55 eyes stable and 6 eyes worsened in western medicine control group.The difference was not statistically significant(P0.05).CONCLUSIONS TCM was more effective than western medicine only on glaucoma patients whose IOP had been controlled.