Objective To optimize the extraction process of Flos Lonicerae and Hawthorn with water for fresh breath effervescent tablets and to provide the basis for the development of new drug of traditional Chinese medicine.Methods The extraction process of Flos Lonicerae and Hawthorn was optimized by orthogonal test,using the extract ratio,organic acid and chlorogenic acid content as indice.Results The optimum water extraction of Flos Lonicerae and Hawthorn condition was:12 times and 10 times of water for 2 cycles,1.5 h and 1 h each time.Conclusion The extraction rate of active components in the drug is high by the selected technology,which is simple,economic,rational and feasible.