Objective To optimize the extraction process of Flos Lonicerae and Hawthorn with water for fresh breath effervescent tablets and to provide the basis for the development of new drug of traditional Chinese medicine.Methods The extraction process of Flos Lonicerae and Hawthorn was optimized by orthogonal test,using the extract ratio,organic acid and chlorogenic acid content as indice.Results The optimum water extraction of Flos Lonicerae and Hawthorn condition was:12 times and 10 times of water for 2 cycles,1.5 h and 1 h each time.Conclusion The extraction rate of active components in the drug is high by the selected technology,which is simple,economic,rational and feasible.

Objective To improve the quality standard of Kouqi Qingxin Paotengpian.Methods Hawthorn in the tables were identified by thin-layer chromatography,the content of chlorogenic acid was determined by HPLC,the separation was performed on an 100-5-C18(250 mm×4.6 mm,5 μm),the mobile phase consisted of 0.4% phosphoric acid-acetonitrile(87∶13),the detective wavelength was 327 nm,the flow rate was 1.0 mL·min-1,and the column temperature was 30℃.Results Hawthorn could be identified by thin-layer chromatography,and the identification was highly specific without interference.The linear range of chlorogenic acid was 0.122 4-0.367 2 μg.The average recovery was 100.4%,RSD=1.7%.Conclusion The method is simple,reliable,and accurate,and can be used for the quality control of Kouqi Qingxin Paotengpian.

Objective To study preparation technology of Fresh breath effervescent tablets.Methods The optimum molding technology was screened through single factor test such as disintegration time,quantity of producing foam,pH value and taste.Results The best preparation process was the optimum water extraction of Flos lonicerae and Hawthorn for 2 cycles,then inspissated and dried using lactose-mannitol(2∶1) and tea polyphenols,followed by pulverizing.Citric acid-tartaric acid(1.5∶1) and sodium bicarbonate were used as effervescent material,sodium bicarbonate as admixture,and CMS-Na was added by two steps.The effervescent tablets had good taste,suitable hardness,good hydros-copicity and valid disintegration time.Conclusion Our preparation procedure is stable and simple.

OBJECTIVE To explore the methods of cardiopulmonary bypass(CPB) quality management during heart suegery.METHODS To establish a CPB database and quality management.The management foundation is based on controlled physiology parameter,and by analysis of the rule of CPB quality changes and definite relationship of between CPB quality level and peri-operative recovery.RESULTS In adults lower score items were hematocrit and venous blood saturation.In the children low score items were urine output,pH and venous blood saturation,the correlated relationship between the CPB quality.Management system score and in hospital service charge,duration of ventilator and lengh of ICU stay was R=-0.445,-0.411,-0.462;P =0.001,0.042,0.01 respectively.The correlated relationship between duration of ventilator and length of ICU stay was R =0.607,P =0.001.CONCLUSION This system could be used to evaluate CPB quality managenent during heart surgey.

自2006年中国第一家试客网诞生后,试用营销、试客经济有了突飞猛进的发展,除了为消费者创造出彻底免费的体验价值外,也衍生出了试客写手这一新兴行业。本文指出商家雇用试客写手属于不正当竞争行为,已经触犯相关法律法规,这是由于网络本身的虚拟性,给一些不法商家提供了可乘之机。试客写手因在其中所充当的角色是否也应当承担相应的法律责任值得做进一步思考。

虽然国家有保护固民在外国合法权益的权利,但是,这项权利的行使要受国际法规定的条件的限制.这些条件有:符合"国籍实际、持续原则",受害人合法权益须受到所在国违反国际法行为的不法侵害,用尽当地救济."干净的手"原则是否应加入到行使条件中还处于争论之中.