Objective:To discuss the galanin content changes and clinical significance,of children with seizure in the epileptic.Method:To determine the galanin contents in plasma by enzyme-linked immunosorbent assay(ELISA),It divide three groups,33 cases of epilepsy group、15 cases with status epilepticus group and 30 cases of normal control group.Results: Plasma of Children with epilepsy group were significantly higher than that galanin status epilepticus group and the normal control group(F=205.911,P0.05);Status epilepticus group and normal control group,no significant difference(t=0.475,P0.05).Conclusion: The relationship is closely between galanin and epilepsy,so galanin may play an anticonvulsant role.