An investigation of clinical efficacy, safety and dispensation in airways of 0.1% salbutamol hemisuccinate nebulized solution was performed in moderate to severe bronchial asthma patients under a 10-day inpatient treatment. The analysis showed the Russian β 2 -agonist to be an effective medication for bronchial asthma inpatient treatment. It fits to all safety requirements and has the equal efficacy but more beneficial cost-effectiveness compared with the foreign analog Ventolin.

One of the most promising trends of the modern medicine today gene therapy is considered to be the way of treatment of many diseases, including hereditary. However, global experience shows that the method is not absolutely safe. Several countries in Europe and other parts of the globe have already added gene therapy supplements to their gene engineering regulation. In the Russian Federation legal aspects of the research and application of gene medicines are much less developed. It is therefore important to develop the criteria for safety evaluation in the application of gene medicines and prepare guidelines for the public registration procedure.

The aim of this work was to analyze the prevalence of level function disorder in patients with atrial fibrillation taking constantly amiodarone. Two groups of patients were studied: in group 1 (n = 78) patients with persistent atrial fibrillation taking constantly amiodarone for rhythm control were included, group 2 (n = 67) consisted of patients with permanent atrial fibrillation taking propafenon, ethacizine and digoxin for rate control. In studied groups liver transaminase activity and data of liver echography after 90 +/- 8 days of treatment were estimated. In 51.58% patients of group 1 asymptomatic increase of liver transaminase activity was found. If liver transaminase activity had been raised before taking amiodarone, frequency and degree of liver transaminase increase extended. Consequently, patients taking constantly amiodarone, require dynamic control of GGTP, AIAT, AsAT once a quarter. If liver transaminase activity increases because of amiodarone taking the method of treatment is possible to be changed and rate control therapy may be chosen.

The aim of this work was to analyze the prevalence of level function disorder in patients with atrial fibrillation taking constantly amiodarone. Two groups of patients were studied: in group 1 (n=78) patients with persistent atrial fibrillation taking constantly amiodarone for rhythm control were included, group 2 (n=67) consisted of patients with permanent atrial fibrillation taking propafenon, ethacizine and digoxin for rate control. In studied groups liver transaminase activity and data of liver echography after 90±8 days of treatment were estimated. In 51,58% patients of group 1 asymptomatic increase of liver transaminase activity was found. If liver transaminase activity had been raised before taking amiodarone, frequency and degree of liver transaminase increase extended. Consequently, patients taking constantly amiodarone, require dynamic control of GGTP, AlAT, AsAT once a quarter. If liver transaminase activity increases because of amiodarone taking the method of treatment is possible to be changed and rate control therapy may be chosen.

Now research of efficiency of medicamentous therapy COPD represents an actual problem in connection with a wide circulation of the given pathology among patients of various age. The purpose: to estimate influence of standard therapy COPD at sick various age groups. Materials and methods: retrospective research of stories of illnesses of patients with COPD, arrived on hospitalisation in 2008, 2009 and 2010. Results: 40 stories have been included in research. Middle age on group has made 57,5 ± 3,4 years, from them there were 13 women (32,5 %) at the age of 57,1 ± 3,5 years and 27 men (67,5 %) at the age of 58,2 ± 4,5 years, smokers among women 6 patients (15 %), men 16 persons (40 %). According to the international recommendations [the Global initiative by chronic obstructive illness of lungs Global Initiative for Chronic Obstructive Lung Disease (GOLD), 2003].: a stage I 3 (7 %) a stage II 14 (35 %) a stage III 15 (38 %) a stage IV 8 (20 %). All patients received therapy COPD (prolonged Theophyllinum, Ipratropium bromide, inhalation with the b2-agonists) which remained invariable on all extent of research. Average hospitalization day of patients of all age groups has averaged 15,4 ± 1,2 days. All patients in all age groups and at various stages have been written out with improvement against positive clinic-laboratory dynamics. Conclusions: efficiency of spent complex therapy COPD does not depend on age of the patient.

ФГУ РОСЗДРАВНАДЗОРА “Научный Центр Экспертизы Средств Медицинского Применения”, г.Москва В настоящее время исследование эффективности медикаментозной терапии фибрилляции предсердий представляет собой актуальную задачу в связи с широким распространением данного нарушения ритма среди пациентов различного возраста [1, 2]. Цель: оценить эффективность стандартной терапии фибрилляции предсердий у больных различных возрастных групп. Материалы и методы: ретроспективное исследование историй болезней пациентов с фибрилляцией предсердий, поступивших на стационарное лечение в МУ «ЦРБ г. Реутов» в 2008-2010 годах. Результаты: в исследование было включено 160 историй болезней 76 мужчин (47,5%) и 84 женщин (52,5%). Согласно рекомендациям рабочей группы ВНОА, АССХ, ВНОК [1] диагностированы следующие формы фибрилляции предсердий: впервые выявленная – у 72 пациентов (45%), пароксизмальная – у 5 пациентов (3,1%), персистирующая – у 7 пациентов (4,4%), постоянная – у 76 пациентов (47,5%). Среди органической патологии сердечно-сосудистой системы преобладающей оказалась ИБС – 110 больных (68,8%), реже встречались пациенты с АГ – 47 человек (29,4%), другие причины развития фибрилляции предсердий (тиреотоксикоз, заболевания клапанов сердца, кардиомиопатии, алкогольная интоксикация) встречались у 13 больных суммарно (8,1%). Больные были разделены на 3 основные группы: 1 группа – пациенты молодого возраста (25-49 лет) – 12 человек (7,5%), пациенты зрелого возраста (50-60 лет) – 43 человека (26,9%), пациенты пожилого возраста (61-82 года) – 105 человек (65,6%). Возрастная градация обследованных пациентов проводилась с учетом классификации, принятой на международном симпозиуме по проблемам геронтологии ВОЗ (Москва, 1961 год). Средний койко-день пациентов всех возрастных групп составил в среднем 13,5±1,5 дня. 84 пациентам (52,5%) проводилась терапия антиаритмическими препаратами различных классов (IA, IC, II, III), 76 пациентов (47,5%) получали ритмоурежающую терапию (бета-адреноблокаторы, недигидропиридиновые антагонисты кальция, дигоксин). Медикаментозная терапия оставалась неизменной на всем протяжении исследования. Все пациенты во всех возрастных группах и с различными формами фибрилляции предсердий были выписаны с положительной клинико-лабораторной динамикой. Вывод: эффективность терапии фибрилляции предсердий не зависит от возраста пациента. Литература. 1. Бокерия Л

Five different types of muscarine-sensitive receptors were identified until now. In routine practice, the nonselective antagonist of cholinoreceptors are replaced by ipratropium bromide that is selectively blocking M1, M2, and M3 subtypes with the same affinity to each of them. However, the blockage of M2 subtype leads to bronchoconstriction and is accompanied by inhibition of M3 receptors in bronchial smooth muscles. The new drug tiotropium bromide selectively inhibits only the M1 and M3 types of receptors and does not affect the M2 subtype. This drug is administered only once a day, which is very important in clinical practice. Thus tiotropium bromide is the drug of choice for basic therapy of COPD.

The largest group of pneumonia diseases, which practicing physicians face daily on an outpatient and hospital basis, is community-acquired pneumonia (CAP). CAP has always been and still stays potentially life-threatening virulent disease, especially for geriatric patients with associated diseases. CAP mortality rate in geriatric patients with associated diseases (such as COPD, CHD, etc.) reaches 30%. Modern international and domestic recommendations for CAP diagnosis and treatment define treatment tactics and rational choice of antibacterial therapy. However, the availability of modern recommendations does not guarantee their use in practice. Noncompliance of different nosologies treatment and irrational drug prescription is a topical issue of national public healthcare.