The analysis of medical documentation of 460 post-vaccination complications of bone system in children vaccinated with BCG-M was made. In 2001-2010, the significant increase of numbers of this form of post-vaccination complications developed exclusively after initial vaccination was established. The characteristics of localization of bone lesions as compared with lesions in case of tuberculosis were established. Despite the present health disorders in mothers during pregnancy most of ill children had no clinical symptoms of diseases testifying the presence of development defects of immune system.
A single inculation of ADP-toxoid with diminished antigen content (5 Lf of diphtheria and 5 BU of tetanus components) for diphtheria and tetanus revaccination of children aged from 1 to 11 years with allergic reactivity provided a marked immunological efficacy with an insignificant reactogenicity. The revaccinating effect was also marked in case of a prolonged lapse of time--up to 10 years (observations period) from the last vaccination. Children with allergic reactivity with contraindications to the administration of APDT vaccine and APDT vaccine and ADT-toxoid of conventional composition can be effectively revaccinated with ADT-toxoid with decreased antigen content on condition of careful clinical observation.