目的：评价以“规模化、规范化、信息化”为核心的高血压社区控制技术对高血压人群管理的效果。

Objective:To study the level and significance of T lymphocyte subsets and activated lymphocytes in peripheral blood of patients with sepsis in different TCM syndromes.Methods: Blood samples were consecutively collected from 26 non-septic control patients and 68 septic patients.By TCM syndrome differentiation,the septic patients were divided into Qi-fen group(n=23),Yin-fen group(n=28) and Xue-fen group(n=17).The expressions of CD+3,CD+3CD+4,CD+3CD+8 cells and CD+3 HLA-DR+,CD+4 HLA-DR+,CD+8 HLA-DR+ of 68 septic patients were detected by flow cytometry;and white blood cell(WBC) counts were measured.Twenty-six healthy individuals served as controls.Results: In comparison with control,there was a significant difference in all the above parameters(all P<0.05).In septic patients,Ying-Fen and Xue-Fen groups have significantly changes on the level of CD+3,CD+3CD+8,CD+3CD+4/ CD+3CD+8,CD+3 HLA-DR+ and CD+8 HLA-DR+ compared to those in Qi-fen group(P<0.05);Xue-Fen group had significantly changes on the levels of CD+3,CD+3CD+8,CD+3 HLA-DR+ and CD+8 HLA-DR+ compared to those in Ying-Fen group(P<0.05) except for CD+3CD+4/ CD+3CD+8(P>0.05).Conclusion: Serum T lymphocyte subsets and activated lymphocytes level altered in patients with different TCM syndromes.Dynamic observation of T lymphocyte subsets and activated lymphocytes could contribute to the TCM syndrome differentiation for sepsis.

目的:观察通心络对老年高血压病肾损害患者血清TGF-β1和PDGF的影响,初步探讨老年高血压病肾损害的发病机制,为临床上寻找新的疗效观察指标和治疗途径提供一定的试验依据.方法:将符合本研究纳入和排除标准的60例患者随机分为通心络组和安慰剂组各30例.两组均起始接受厄贝沙坦片控制血压达标(130/80 mmHg),达目标血压后通心络组和安慰剂组在原有治疗基础上分别加服通心络胶囊和安慰剂.两组在加服通心络胶囊和安慰剂之前均需测定TGF-β1、PDGF和肾功能指标,其中肾功能指标包括内生肌酐清除率(Ccr)、尿微量白蛋白(UmALB)、尿β2-微球蛋白(Uβ2-MG).两组加服后持续治疗12周再次检查上述项目.结果:通心络组TGF-β1和PDGF治疗前后组内比较有显著性差异(P＜0.05)；安慰剂组TGF-β1和PDGF治疗前后组内比较无显著性差异(P＞0.05)；两组肾功能指标治疗前后组内比较均有显著性差异(P＜0.05)；两组TGF-β1、PDGF和肾功能指标治疗后组间比较均有显著性差异(P＜0.05).结论:通心络可协同厄贝沙坦进一步改善老年高血压病肾损害患者的肾功能,并且这种作用可能与抑制TGF-β1和PDGF的表达有关.

Objective:To study the changes and clinical significance of the in septic patients with different TCM syndromes.Methods:Blood samples were consecutively collected from 26 non-septic control patients and 68 septic patients.By TCM Syndrome Differentiation,the septic patients were divided into Qi-fen group(n=23) ,Yin-fen group(n =28) and Xue-fen group(n =17) .Serum soluble thrombomodulin(sTM) ,E-selection(E-SLT) ,Endothelin(ET-1) ,tumor necrosis factor(TNF)-α,interleukin(IL)-6,2,4 and white blood cell(WBC) count were measured.Results:In comparison with control,there was a significant difference in all the above parameters(all P 0.05) except for IL-2;In septic patients,the Xue-Fen group has significantly increased sTM level compared to the control and Qi-fen group(P 0.05) .Conclusion:Serum sTM level altered in patients with different TCM Syndromes.Dynamic observation of serum sTM could contribute to the TCM Syndrome Differentiation for Sepsis.