Objective To explore the impact of depressive symptoms on quality of life in patients with bipolar disorder and the mediating psychological factors involved.Methods Using convenience sampling,235 patients with bipolar disorder who visited outpatient clinics and inpatient wards of the Departments of Psychiatry at the Third Affiliated Hospital of Sun Yat-sen University,the Affiliated Brain Hospital of Guangzhou Medical University,and Xiamen Xian Yue Hospital from April 2019 to September 2025 were enrolled,along with 68 healthy individuals from the Zhongshan 2nd Road Community and the Guanjun Community in Guangzhou.Participants were assessed using a general information questionnaire,the Hamilton Depression Rating Scale-17(HDRS-17),the Young Mania Rating Scale(YMRS),neurocognitive function tests,the Resilience Questionnaire for Bipolar Disorder(RBD),the Rosenberg Self-Esteem Scale(RSES),the Functioning Assessment Short Test(FAST)and the 12-item Short-Form Health Survey(SF-12).Pearson correlation analysis and multiple linear regression analysis were performed,and a mediation effect model was constructed and tested.Results Both the SF-12 physical component summary(PCS-12)score(r=-0.298,P＜0.001)and the mental component summary(MCS-12)score(r=-0.422,P＜0.001)of quality of life were negatively correlated with depressive symptoms score.The MCS-12 score of quality of life was also negatively correlated with self-esteem score(r=-0.321,P＜0.001)and positively correlated with resilience scores(r=0.158,P=0.026).Further regression analyses showed that more severe depressive symptoms(t=-3.571,P＜0.001),older age(t=-3.088,P=0.002),and greater impairment in the cognitive functioning dimension of psychosocial functioning(t=-2.696,P=0.008)were associated with poorer quality of life in the physical component.More severe depressive symptoms(t=-3.992,P＜0.001),higher self-esteem level(t=-3.439,P=0.001),greater impairment in the interpersonal relationships dimension of psychosocial functioning(t=-2.830,P=0.005),better quality of life in the physical component(t=-2.579,P=0.011),and higher educational level(t=-2.268,P=0.024)were associated with poorer quality of life in the mental component.The mediating effect model indicated that depressive symptoms could directly predict the MCS-12(β=-0.317)and could also influence it through three pathways:self-esteem(β=-0.081),resilience(β=-0.022),and a chain mediation pathway involving self-esteem and resilience(β=-0.028).Conclusion Depressive symptoms have a direct impact on the mental component of quality of life in patients with bipolar disorder and also exert indirect effects through the mediating role of self-esteem,the mediating role of resilience,and the chain mediating effects of self-esteem and resilience.

Bipolar disorder is a severe mental illness, while allergic rhinitis is a common allergic disease. Both are common diseases that significantly affect patients' quality of life. Previous epidemiological studies have suggested a high comorbidity rate between the two, but the underlying mechanism of their association remains unclear. They may share a dynamic pathophysiological network composed of multiple factors interacting with each other, with potential mechanisms involving immunoinflammation, neuroendocrine regulation, sleep disorders, and environmental factors. This article delves into the connection between them from two aspects: epidemiology and comorbidity mechanism, aiming to deepen clinicians' understanding of comorbidity between the two. The article also analyzes the integrated treatment management strategies for comorbidity of bipolar disorder and allergic rhinitis, suggesting the need for a multidimensional and multidisciplinary integrated strategy based on shared pathological mechanisms, establishing an interdisciplinary collaboration model for early identification and comprehensive assessment of patients. For pharmacological treatment of such patients, priority should be given to drugs with both mood stabilizing and potential anti-inflammatory effects (such as some atypical antipsychotics), and the rational use of first-line drugs for allergic rhinitis (such as nasal steroids) should be emphasized. Attention should also be paid to adverse drug reactions, while psychological intervention, sleep intervention, and lifestyle intervention are of great significance in the long-term management of patients.

Objective The literature on large-scale studies of Chinese patients with adolescent-onset bipolar disorder (adolescent-onset BD) was limited. Based on the analysis of the National Bipolar Mania Pathway Survey (BIPAS) Phase II data, we examined the demographic and clinical characteristics of adults with adolescent-onset BD. Methods Among 899 participants diagnosed with BD from 20 mental health services, demographics and clinical data were collected at screening. Comparisons were made using chi-square (or Fisher's exact) tests and ANOVA. Multivariate logistic regression identified independent factors for adolescent-onset BD, and a CHAID decision tree analysis (SPSS) was constructed to detect risk factors. Results In the sample, 360 (40%) had adolescent-onset BD and 539 (60%) adult-onset BD. Significant differences between the two groups were observed in current age, number of episodes, years of education, gender, age of onset, education level, marital status, occupation, comorbid chronic physical illness, and first episode type. Stratified analysis also revealed significant differences between adolescent-onset BD I and BD II. Multivariate logistic regression identified younger onset age, more frequent episodes, lower education level, marital status, occupation, first episode type, and prior hospitalization as independent factors for adolescent-onset BD. The decision tree model selected current age as the first splitting variable, followed by occupation and marital status as the second, and years of education and prior hospitalization as the third. Conclusions Adolescent-onset BD exhibits distinct demographic and clinical features compared to adult-onset BD. Early recognition and tailored treatment strategies may improve prognosis and outcomes in this population.

ObjectiveDelayed sleep-wake phase disorder (DSWPD) is commonly seen in bipolar disorder (BD). However, valid screening tools for DSWPD have not been available, especially in China. Therefore, this study aimed to explore the validation of the Morningness-Eveningness Questionnaire (MEQ) for screening DSWPD with BD among Han Chinese population.MethodsA total of 267 patients with bipolar disorder and 130 healthy controls were screened with the Chinese version of Morningness-Eveningness Questionnaire (MEQ) for DSWPD. Of these, 49 completed the re-test after 2 weeks. The DSWPD diagnosis was based on clinical interview with the patients and related informants by trained psychiatrists according to the diagnostic criteria of the International Classification of Sleep Disorders (3rd edition, ICSD-3). Cronbach’s α coefficient, split-half reliability coefficient, and the Intra-class Correlation Coefficient (ICC) were calculated to assess the reliability of MEQ. The receiver operating characteristic curve (ROC) was plotted to evaluate MEQ performance. The optimal cut-off was chosen by maximizing the Youden index.ResultsThe internal consistency, split-half, and retest reliabilities of the MEQ were 0.758, 0.719, and 0.661, respectively. Three factors were obtained for the MEQ scale based on Exploratory factor analysis, with a cumulative factor loading of 37.384%. BD patients with DSWPD had significantly lower MEQ scores (36.85 ± 6.40) compared to BD patients without DSWPD (47.44 ± 7.39) and healthy controls (47.96 ± 7.28) (both p<0.001). The area under the ROC curve (AUC) was 0.867. The Youden index was the highest when a MEQ score of 43 was used as the cut-off point, with a sensitivity of 0.83 and a specificity of 0.75.ConclusionThe Chinese version of MEQ is a valid screening tool for DSWPD among bipolar disorder patients.

BackgroundPersonality traits are closely related to psychiatric disorders, but their role in distinguishing major depressive disorder (DD) from bipolar disorder (BD) remains unclear. The Big Five Inventory (BFI) is widely used to assess personality, yet findings on trait differences between BD and MDD and their relationship with clinical features are inconsistent. This study examines how personality traits vary across mood disorders and their associations with clinical features.ObjectiveThis study aims to investigate how Big Five personality traits differ between major depressive disorder (MDD) and bipolar disorder (BD) and to explore their associations with clinical characteristics, including illness severity, hospitalization history, and comorbidities, in a sample of Han Chinese women.MethodsA cross-sectional analysis was conducted on BD, MDD, and healthy participants. Personality traits were assessed using the Chinese version of BFI-44, and clinical data including depression severity (HAMD scores), hospitalization history, and comorbidities were collected. Multiple regression, multivariate analysis of variance (MANOVA) and structural equational model (SEM) were used to examine group differences and associations between personality and clinical variables.ResultsBD and MDD patients exhibited higher neuroticism than healthy controls (p<0.001). BD patients had lower agreeableness than MDD (β=-0.14, p=0.04), while extraversion did not significantly differentiate the disorders. BD-I patients had higher openness than BD-II (M=2.78, p=0.02) and higher conscientiousness than BD-NOS (M=3.51, p=0.03). Higher openness correlated with physical comorbidities (β = 0.19, p = 0.01), and neuroticism was strongly linked to depression severity (β = 0.26, p < 0.001).ConclusionsNeuroticism is a key marker of psychiatric illness, while agreeableness distinguishes BD from MDD. The associations between personality, illness severity, and treatment engagement highlight their potential clinical relevance and need for further study.

Background Bipolar disorder (BD) is often underdiagnosed or misdiagnosed due to limitations in current diagnostic tools, which may not adequately capture the disorder’s defining characteristics, such as symptom polarity and instability. Existing self-report scales, like the MDQ and HCL-32, have limited sensitivity and are not culturally tailored to Chinese populations. To address this gap, a new self-report questionnaire was developed to aid in the differentiation between unipolar and bipolar depression, with an emphasis on broader symptom coverage. Methods A 21-item self-rated questionnaire was drafted and administered to 445 patients with Major Depressive Disorder (MDD) or Bipolar Disorder (BD) confirmed by structural diagnostical interview according to DSM-5 and a at least 6-month follow-up. The internal consistency was assessed using Cronbach's alpha, structural validity was evaluated through confirmatory factor analysis, and the screening performance was determined using an ROC curve analysis. Results The Cronbach's coefficient for the entire questionnaire was 0.872. Exploratory factor analysis revealed four factors with a cumulative variance contribution of 46.22%. The questionnaire demonstrated good sensitivity (0.66-0.84) and specificity (0.58-0.71) for different BD subtypes, with AUC values ranging from 0.689 to 0.741. Conclusion The Bipolarity Questionnaire is a reliable and valid tool for differentiating unipolar and bipolar depression, with a broader symptom assessment compared to existing tools.

There is a high prevalence of suicidal ideation (SI), suicide attempts (SA), and non-suicidal self-injury (NSSI) in bipolar disorder (BD). Understanding the nature of suicidality and NSSI in BD is an important way to inform optimal intervention for reducing suicide risk. We aimed to investigate the prevalence and correlates of SI, SA, and NSSI in patients with BD using data from a national survey. We used network analysis to explore the associations among suicidality, NSSI, addictive features of NSSI, and symptoms of BD. Participants with BD were recruited from 20 research centers in China. Suicidality, NSSI, addictive features, and symptoms of BD were measured via a standardized electronic case report form. We used logistic regression and network analysis for data analysis. Of the 1,055 participants recruited, over 50

Patients with bipolar disorder (BD) who also experience delayed sleep-wake phase (DSWP) disorder/syndrome may tend to be younger, have a higher risk of relapse, and exhibit more severe impairments in social functioning. However, few studies have explored this area, and there are currently no established treatment guidelines, prompting us to investigate this further through a case series. We report on a chart review of 15 patients diagnosed with bipolar disorder (BD) and delayed sleep-wake phase (DSWP) syndrome, who received Aripiprazole (APZ) monotherapy for 12 to 135 weeks. Efficacy was observed within the first two weeks, indicated by reductions in Clinical Global Impressions-Severity (CGI-S) scores and an advancement of the sleep-wake cycle. By the final visit, 93.3

OBJECTIVE:We collected maintenance treatment medication information from Chinese multicenter bipolar disorder patients, exploring the characteristics of medication use and related factors. We analyzed medication guideline adherence and compared trends in medication use with a study from 2014. METHODS:323 patients receiving maintenance therapy for bipolar disorder across 20 hospitals have been recruited. Their prescription information was collected to compare with the recommended drug protocols outlined by CANMAT to assess consistency. Additionally, descriptive statistics were conducted to document the quantities and percentages of different classes of medications used. Regression analysis was employed to explore factors influencing medication choices. RESULT:The rate of medication inconsistency in this study was 12.38 %, characterized by inappropriate use of antidepressants and mood stabilizers. The rate of using additional drugs was 67.80 %, with antipsychotics being the most common adjunctive treatment in the Bipolar I group and antidepressants in the Bipolar II group. Factors influencing the occurrence of adjunctive therapy included previous hospitalization, most recent episode type, and gender. The rate of polypharmacy was 47.10 %, with previous hospitalization and most recent episode type being the main influencing factors. CONCLUSION:There has been a noticeable improvement in guideline concordance in medication use compared to 2014; however, improper use of antidepressants remains a significant clinical issue. The increasing prevalence of adjunctive medication use underscores the need for more personalized medication recommendations in clinical guidelines.

Abstract Background Metabolic syndrome (Mets) is commonly seen in bipolar disorder (BD). As the key component and early biological index of Mets, insulin resistance (IR) among BD has received more and more attention. However, little is known about the prevalence of IR and its associated factors in drug-naïve patients with (BD), especially among Han Chinese population. Methods A cross-sectional study was conducted on 125 drug-naïve patients with bipolar disorder (BD) and 85 healthy controls (HC). The Homeostatic Model Assessment of insulin resistance (HOMA-IR) was calculated, and IR was defined as HOMA-IR greater than the 75th percentile value for health controls (2.35). Clinical characteristics of BD were collected through semi-structural interview performed by a trained interviewer with background of psychiatric education. Results Among the measured anthropocentric variables including BMI, waist circumference, abdomen circumference, hipline, and hip-waist ratio, waist circumference was found to be the most closely related to IR (0R = 1.070, 95%CI = 1.031–1.110, P < 0.001). Male was another factor that was associated with IR (OR = 2.281, 95%CI = 1.107–4.702, P = 0.025). After adjusted for gender and waist circumference, the risk of IR was significantly higher in bipolar disorder than in healthy controls (OR = 2.66, 95%CI = 1.364–5.214, P = 0.004). No significant association was found between IR and any of the observed physical and mental comorbidities, any characteristic of illness course including age onset, number of mixed episodes, types of current state, duration of current episode, duration of illness course, rapid cycling, number of mood episodes, and subgroup of BD. Hypersomnia was the only symptomatic feature that was significantly associated with IR (OR = 0.316, 95%CI = 0.124–0.803, P = 0.016). Conclusions Bipolar disorder increases two-to-three-fold risk of IR, both circumference and male are the risk factors of IR but hypersomnia act as a protective factor.

经前期综合征和双相障碍都是常见的精神障碍,两者在临床症状、病程等方面有相似之处,而且常常同时发生,严重影响患者的社会功能.目前国内关于经前期综合征与双相障碍共病的研究较少,该文就两者共病的流行病学、可能的共病机制、诊断要点以及治疗方面进行综述.

Bipolar disorder (BD) is commonly comorbid with premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD). However, little is known about their relationship. This study aimed to assess the impact of comorbid PMS or PMDD on the clinical characteristics of BD. A cross-sectional study was conducted on 262 women with BD. PMS and PMDD were screened with the Premenstrual Symptoms Screening Tool (PSST). Symptomatic features were assessed with Hamilton Depression Scale (HAMD), Young Mania Rating Scale (YMRS), and atypical features by the depressive episode section of SCID-I/P. The rates of PMS and PMDD among BD were 57.6% and 20.6% according to PSST. No significant difference in the rates of PMS and PMDD was found between BD I, BD II, and BD-NOS. Compared to BD patients without PMS or PMDD, patients with comorbid BD and PMS or PMDD were younger, more educated, had a higher risk of OCD, had an earlier age of onset, scored higher on HAMD-17 and its sub-scale of anxiety/somatization, cognitive deficit, psychomotor retardation, and were more likely to have increased appetite and leaden paralysis. In addition, patients with comorbid BD and PMDD were less likely to experience traumatic life events, more likely to have family history of mental disorders and have inflammatory or autoimmune disease, scored higher on HMAD-17, particularly in its sub-scale of anxiety/somatization, cognitive deficit, psychomotor retardation, and sleep disturbance. Compared with BD without PMS or PMDD, BD with PMS or PMDD might be a specific subtype of BD characterized with earlier onset age, heavier genetic load, increased symptom severity, and atypical features.

Objective:This study investigates the difference in the detection rate and symptomatology between ICD-10 and DSM-5 diagnostic criteria for bipolar disorder with mixed states.Methods:Based on the Phase Ⅰ (2012) and Phase Ⅱ (2021) databases of National Bipolar Mania Pathway Survey (BIPAS), patients with bipolar disorder were included. General demographic data, clinical characteristics, symptomatic phenotypes, and mixed characteristics were retrieved. The detection rates and symptomatic performances of patients with or without mixed states in Phase Ⅰ and Ⅱ were compared using the chi-square test.Results:For patients with mixed states, the detection rate during Phase Ⅱ (2021) using DSM-5 (18.79%, 199/1 059) criteria was significantly higher than that during Phase Ⅰ (2012) using ICD-10 (6.78%, 199/2 934; χ 2=125.05, P<0.001). Whether using ICD-10 or DSM-5 criteria, patients with mixed states had a significantly higher frequency of multiple symptomatic manifestations. Conclusion:The DSM-5 diagnostic criteria generate a high detection rate for bipolar disorder with mixed states. The clinical phenotypes of bipolar disorder with mixed states vary significantly using different diagnostic tools.

Background To explore the relationship between serum levels of inflammatory markers and symptomatic severity of bipolar disorder (BD). Materials and methods A cross-sectional study was conducted on 126 BD patients with current depressive episode (BDD), 102 BD patients with current mixed or (hypo)manic episode (BDM) and 94 healthy controls (HC). All participants were drug-naïve and had no current active physical illness associated with inflammatory response or history of substance abuse. Fasting serum levels of CRP, leptin (LEP), adiponectin (ADP), visfatin (VIS), TNF-α, IL-2, IL-6, IL-10, IL-17), and monocyte chemoattractant protein-1 (MCP-1) were measured with enzyme-linked immunosorbent assay (ELISA). Symptomatic severity of BD was assessed with HAMD-17 and YMRS. Generalized linear model was used to determine the association between the serum levels of inflammatory markers and symptomatic severity of BD. Results The serum levels of IL-6, IL-10 and IL-17, and the IL-6/IL-10 ratio were significantly lower in mild BDD than in HC. In moderate BDD, the serum levels of MCP, IL-6 and IL-17 were significantly lower than in HC. In severe BDD, the serum level of ADP, MCP-1, IL-10 and IL-17and the IL-17/IL-10 ratio were significantly lower than in HC. The serum levels of TNF-α and the IL-6/IL-10 ratio were significantly higher in mild BDM than in HC. In moderate BDM, the serum level of VIS, IL-2, and IL-17 were significantly higher than in HC, but the IL-6/IL-10 ratio was significantly lower than in control. In severe BDM, the serum levels of IL-6 and IL-17 and the ratios of IL-6/IL-10 and IL-17/IL-10 were significantly lower than in HC, but the neutrophil/lymphocyte ratio was significantly higher than in HC. Conclusion In BDD, immune-inhibition is persistently predominant, while in mild-to-moderate BDM, immune system is activated but inhibited in severe BDM. The dynamic change of serum inflammatory markers suggests that alteration of peripheral inflammatory markers in BD is state-dependent instead of trait-marked.

Trichotillomania (TTM) is an intractable and chronic mental disorder that causes significant distress or functional impairments in various life domains. Most individuals with trichotillomania have other comorbid diagnoses. Bipolar disorder (BD) is one of the most common comorbid conditions. Up to date, no FDA-approved drugs for TTM are available, not to mention children and adolescent patients with TTM and BD. Here, we present a case of an 8-year-old child with a long history of episodic TTM and bipolar disorder who was effectively treated with topiramate in a 3-year follow-up.

我们都知道抑郁症,其实躁郁症也很常见.2019年,北京大学附属第六医院黄悦勤教授做了一个全国流行病学调查,发现躁郁症患病率约为0.5％,按人口基数算,有超过700多万名躁郁症患者.2011年深圳参与了世界卫生组织发起的一项流行病学研究,发现当地躁郁症患病率更高达1.5％.

Introduction: Dehydroepiandrosterone sulfate (DHEAS) has been reported to be associated with sexual function and general psychological health respectively, however, no one has ever examined their mutual relationships in a single study. Aim: The aim of the present study was to find out whether DHEAS, general psychological health, and erectile function were all associated with each other. Methods: A cross-sectional study was conducted on 34 patients with erectile dysfunction (ED) and 32 healthy controls (HC). The levels of serum DHEAS were assessed by chemiluminescence method. Erectile function and general psychological health were measured by International Index for Erectile Function-5 (IIEF-5) and General Health Questionnaire 20(GHQ-20) respectively. Main Outcome measure: The primary outcome measure of this study was the mutual correlations of serum DHEAS levels, general psychological health and erectile function. Results: Compared to HC, patients with ED had a significant lower serum levels of DHEAS (6.43 ± 2.70 μmol/L vs 9.48 ± 2.82 μmol/L, P < .001) and higher scores on GHQ-20 (35.06 ± 8.56 vs 24.97 ± 2.55, P < .001). Multivariate binary logistic regression showed that both serum levels of DHEAS (OR = 0.667, 95% CI = 0.512–0.869, P = .003) and psychological distress (scores of GHQ-20 > 28) (OR = 6.921, 95% CI = 1.821–26.305, P = .005) were significantly associated with ED. However, no significant association between psychological distress and serum levels of DHEAS was found (OR = 0.798, 95% CI = 0.623–1.021, P = .072) after controlling for ED. Partial correlation analysis revealed that both scores of GHQ-20 (r = −0.595, P < .001) and DHEAS (r = 0.450, P < .001) were significantly correlated with scores of IIEF-5, while no significant relationship was found between scores of GHQ-20 and DHEAS (r = 0.116, P = .363) after controlling for scores of IIEF-5 and age. Conclusion: Both serum levels of DHEAS and general psychological health are significantly associated with erectile dysfunction in sexually active adult men but the relationship between general psychological health and erectile function seems to be independent of DHEAS.Li K, Liang S, Shi Y, et al. The Relationships of Dehydroepiandrosterone Sulfate, Erectile Function and General Psychological Health. Sex Med 2021;9:100386.

Background: Medication non-adherence is prevalent in patients with bipolar disorder (BD). Long-acting injectable antipsychotics (LAIAs) are widely used to improve compliance with treatment. This study aimed to illustrate the effectiveness, compliance, and safety profile of once-monthly paliperidone palmitate (PP1M), a novel therapeutic LAIA, in the management of bipolar I disorder (BDI). Method: A prospective follow-up was arranged to 11 BDI patients who were prescribed PP1M as monotherapy or adjunctive treatment. Severity of symptoms, disturbing behavior, status of employment, 17-item Hamilton Depression Rating Scale (HAMD-17), and Young Mania Rating Scale (YMRS) were evaluated at the baseline and the endpoint of follow-up. Clinical Global Impression—Bipolar Disorder—Severity of Illness Scale (CGI-BP) and Treatment Emergent Symptom Scale (TESS) were measured at each injection of PP1M. Compliance, relapse or switch, and new hospitalization were monitored through the period of follow-up. Results: The median duration of treatment was 14 months, ranging from 5 to 22 months. The scores (mean ± standard deviation) of HAMD-17, YMRS, and CGI-BP generally decreased from the baseline (16.1 ± 10.3, 30.9 ± 12.6, 5.3 ± 0.7) to the endpoint (7.4 ± 5.7, 3.7 ± 3.2, 2.3 ± 0.7). No disturbing behavior was detected at the endpoint. Neither new hospitalization nor manic/mixed episode occurred during treatment, whereas mild to moderate depressive episodes were reported in three cases. The status of employment of 10 participants (90.9%) was improved, and no new safety concern was detected. Conclusion: PP1M might offer a new valid treatment option in the long-term management of BDI, especially for those with poor compliance with oral medication. However, more studies are needed to further justify such role.

All authors report no biomedical financial interests or potential conflicts of interest. The data that support the findings of this study are available on request from the corresponding author (Zhaoyu Gan, Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou, China, 510630. moyanchou@163.com). The data are not publicly available due to privacy or ethical restrictions.

Objective:To explore the application of various teaching methods in improving the doctor-patient communication skills of medical students.Methods:It was a prospective self-control study. From January 2017 to December 2017, Before entered into psychiatry department of the Third Affiliated Hospital of Sun Yat-sen University, medical students were evaluated for "the Communication Skills Attitude Scale" and "the Medical Students' Doctor-Patient Communication Behavior Scale" , within the following six months a variety of ways of communication skills training, including internship lectures, interactive teaching and new media teaching, scale assessment again after 6 months. The most effective teaching methods were chosen by students.Results:After training, the communication skill of medical students in all aspects was improved, the negative attitude was reduced (35.22±4.35 vs 28.40±3.54), the positive attitude was increased (53.20±5.35 vs 60.84±2.72), the difference was statistically significant ( P<0.05); the medical students' communication behavior scale before and after training (151.78±5.33 vs 166.27±4.36), the difference was statistically significant ( P<0.05). Before training, male students' positive attitude score towards doctor-patient communication were worse than female students (51.41±4.88 vs 54.91±5.33), while malestudents' negative attitude score was higher than female students(36.68±4.80 vs 33.83±3.42). After training, the support score of male students were worse than female students(16.86±1.52 vs 17.83±1.27), and the differences were statistically significant ( P<0.05). The most effective training method favored student was simulation teaching 46.7% (63/135), followed by WeChat 28.9% (39/135). Conclusions:Various teaching methods can improve doctor-patient relationship, students of different genders have different communication abilities and preferences for teaching methods. Among them, simulation teaching in interactive teaching and WeChat platform as the new media teaching facilites are relatively effective, which are worthy of further improvement.