目的 通过可视化分析从宏观角度呈现中医传承领域的研究概况、研究热点和前沿,分析未来发展趋势,为中医传承发展提供参考.方法 利用CiteSpace软件对2004-2018年间发表于中国知网(China National Knowledge Internet,CNKI)的中医传承研究领域论文进行分析,将该领域主要科研团队、科研机构、发文数量、研究焦点及走向以知识图谱形式呈现.结果 中医传承研究发文数量从2004-2010年期间处于起始期和缓慢增长期,自2011年后处于显著增长期,以唐仕欢为代表的科研团队和以山东中医药大学为首的科研院校为中医传承做出了较大贡献.中医传承辅助软件的应用极大方便和扩展了传承的内容和深度,传承研究日趋细化、数据化、客观化.结论 国家采用科研立项、国医大师评选等一系列扶植中医的政策及名师带徒等具体传承工作的实施是中医传承研究领域迅速升温的直接原因.计算机、统计学的发展以及中医传承软件的开发为中医传承研究注入了新活力.预计在今后相当长一段时间内,围绕中医传承实践方法的探索、基于人工智能的数据挖掘技术的开发及传承软件升级将是该领域持续关注的焦点.

目的 探讨自拟通痹方治疗气滞血瘀兼寒湿阻络型腰椎间盘突出症的临床效果及安全性.方法 选取2017年10月-2018年10月吉林大学第一医院中医科门诊气滞血瘀兼寒湿阻络型腰椎间盘突出症的患者88例,分成观察组及对照组,观察组给予腰椎间盘突出症穴位针刺配合口服自拟通痹方,对照组给予甲钴胺片配合腰椎间盘突出症穴位针刺.连续治疗1个疗程后对比两组患者治疗前后的症状积分,统计临床疗效.结果 口服自拟通痹方结合腰椎间盘突出症穴位针刺治疗前后总有效率85.29％、JOA疼痛评分P<0.05、具有统计学意义,且观察组优于对照组.结论 口服自拟通痹方结合针刺治疗气滞血瘀兼寒湿阻络型腰椎间盘突出症效果显著,能改善腰椎间盘微循环,减轻患者疼痛感.

Objective To observe the curative effect of breast massage combined with external application of traditional Chinese medicine in treatment of acute mastitis during lactation period.Methods Sixty patients with acute mastitis dnring lactation period meeting the inclusion criteria were selected and randomly divided into massage group,external application group,and observation group,20 patients in each group.The patients in massage group were treated by breast massage,the patients in external application group were treated by external application of traditional Chinese medicine (frankincense,rhizoma cyperi,radix curcumae,raw Angelica dahurica,pericarpium citri reticulatae viride,and spina gleditsiae),and the patients in observation group were treated by breast massage combined with external application of traditional Chinese medicine.The effective rates,recovery time of clinical symptoms,WBC and C-reactive protein (CRP) levels after one course of treatment in the three groups were observed.Restults There were statistically significant differences in effective rate,recovery time of clinical symptoms,WBC and CRP levels among the three groups (all P＜0.05),the above-mentioned indexes in observation group were significantly superior to the other two groups (P＜0.05).Conclusion Both breast massage and external application of traditional Chinese medicine can improve clinical symptoms,WBC and CRP levels in patients with acute mastitis during lactation period,but the curative effect of breast massage combined with external application of tralitional Chinese medicine is more significant.

Objective To observe the clinical efficacy of Jixian Tongbi decoction in the treatment of protru-sion of lumbar intervertebral disc and its effect on serum inflammation media.Methods The patients will conform to the standard of 80 cases of protrusion of lumbar intervertebral disc, they were randomly divided into two groups, the observation group and control group (n=40). Two groups were given routine acupuncture treatment, the control group were given celebrex, observation group was given Jixian Tongbi decoction (rhizoma cibotii, dipsacus asperoids, radix clematidis, angelica pubescens, herba taxilli,rhizoma corydalis, achyranthes bidentata,herba lycopodti, cinnamomum cassia presl, radix paeoniae alba, radix glycyrrhizae, etc.). Observe the effectiveness of two groups before and after treatment, pain JOA score, serum tumor necrosis factor alpha (TNF alpha), interleukin 1 (IL 1) content. Results The two groups before and after treatment of efficient, JOA score, TNF alpha, IL -1 have significant differences, observation group is better than control group (P<0.05).Conclusion Jixian Tongbi Granule can reduce the content of TNF alpha and IL-1 in patients blood, and it has a good effect for the treatment of protrusion of lumbar intervertebral disc.

Objective To observe the Huoxue tongluo qingnao decoction treat the clinical curative effect of the senile patients with transient ischemic attack and its influence on cerebral blood flow dynamics and fibrinogen. Meth-ods A total of 126 senile patients with the diagnostic criteria of transient ischemic attack were included in the study and randomized into the observation group( n=63 )and the control group( n=63 ). The patients in the two groups were given Clopidogrel Sulfate Tablets and Bayaspirin for the routine treatment,the patients in the observation group were given the Huoxue tongluo qingnao decoction. The improvements of the clinical symptoms,TCD shows the average vertebral-basilar artery blood flow velocity and fibrinogen level before and after intervention between the two groups is compared. Results The clinical symptoms of the observation group improve the total effective rate was 95. 23% after treatment,the control grope symptoms improve the total effective rate was 90. 47% after treatment. Observation group in improving clinical symptoms,the average vertebral-basilar artery blood flow velocity and fibrinogen contents has distinct curative effect,and obviously better than that of control group(P﹤0. 05),with statistical significance. Con-clusion Huoxue tongluo qingnao decoction can effectively improve the clinical symptoms,average vertebral artery blood flow velocity and fibrinogen contents.

Objective: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain-Barre syndrome classic animal models.Materials and methods: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin-eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application.Results: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ.Conclusion: This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain-Barre syndrome.

Objective: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models. Materials and methods: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin–eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application. Results: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ. Conclusion: This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain–Barré syndrome.

目的:分析创新三参滋胃颗粒对慢性萎缩性胃炎大鼠胃液及胃泌素的治疗机制,为新制剂的临床实用提供依据.方法:选择Wistar大鼠110只,雌雄各半,随机分成两组,空白对照组12只和模型对照组98只,造模68 d后,将造模动物分为5组:模型对照组18只、创新三参滋胃颗粒小、中、大剂量组和维酶素组各16只.所有造模大鼠在继续采用造模刺激因素的基础上,同时以三参滋胃颗粒小、中、大剂量,维酶素连续治疗57 d;空白组和模型对照组给予相同体积的蒸馏水.观察各组大鼠的一般情况、胃液及胃泌素情况.结果:模型组大鼠造模成功.经药物治疗后,与模型组相比,中、大剂量三参滋胃颗粒组和维酶素组的一般情况明显改善.与模型组比较,三参滋胃颗粒中,大剂量组胃液明显增加,具有显著性差异(P＜0.01),胃液总酸度升高,有显著差异(P＜0.05),血清胃泌素含量降低,有显著性差异(P＜0.05).结论:三参滋胃颗粒可以明显提高慢性萎缩性胃炎大鼠胃液情况,改善大鼠胃泌素情况,为改制剂的临床长期应用提供了可靠依据.

带状疱疹为皮肤科与神经内科及中医科常见病、多发病，带状疱疹消退后常后遗顽固性神经痛，中医学称此病为“蜘蛛疮”，“缠腰火丹”，“串腰龙”等，但带状疱疹后遗神经痛（PHN）的中医药治疗临床及实验研究的报道较少。本文应用中药自拟疱疹止痛灵（HNK）治疗PHN，对其治疗效果进行临床评价。

目的:观察自拟中药复方制剂加味脑心康治疗慢性疲劳综合征的临床疗效。方法:将68例患者随机分为治疗组40例和对照组28例,治疗组给予口服中药加味脑心康(人参、赤芍、鸡血藤、何首乌、川芎、当归、地龙等),对照组给予三磷酸腺苷,均为每日2次,通过疲劳量表及匹兹堡睡眠质量指数量表、临床疗效表现,观察治疗后2组症状改善程度。结果:治疗组临床总有效率为95.00%,对照组为78.57%,2组比较,P<0.05;治疗组治疗前FS量表分值为(8.44±2.04),治疗后分值为(2.12±2.30),治疗前后比较,P<0.01;治疗后治疗组与对照组匹兹堡睡眠质量指数量表分值分别为(5.22±1.30)和(9.61±2.05),2组比较,P<0.05。结论:加味脑心康治疗慢性疲劳综合征具有良好临床疗效。

Objective:Compare the proposed traditional prescription joint metalizing and mesalazine treatment the curative effect of ulcerative colitis,provide rational drug use advice for clinical treatment of ulcerative colitis.Method: Ninty cases of ulcerative colitis patients in our hospital from June 2010 to May 2011,randomly divided into treatment group(45 cases) and control group(45 cases),were given the proposed traditional prescription joint mesalazine and mesalazine treatment respectively.After that,compare with two groups of treatment effective rate,under colonoscopy form change,C-reactive protein(CRP),ergthrocyte sedimentration rate(ESR) etc,evaluate its effectiveness and safety.Result: The treatment effective rate and under colonoscopy form change of the two groups after treatment are all have statistical significance(P0.05).Conclusion: The curative effect of the proposed traditional prescription joint mesalazine is better than that of mesalazine.It is worthy of clinical application.

Objective To observe of integrated traditional Chinese and Western medicine without operation method in the treatment of adhesive intestinal obstruction.Methods With simple Western medicine treatment and configure decoction by nasogastric tube,treating combined with fasting,gastrointestinal decompression,anti-inflammatory rehydration vein nutrition method of traditional Chinese medicine and Western Medicine.Results 45 cases were cured among 60 cases of integrated traditional Chinese and Western medicine.Effective 11 cases,invalid 4 cases,the effective rate was 75%,the total efficiency of 93%.Invalid 4 cases converted to laparotomy.Significant efficiency.The two groups after treatment the total efficiency were compared with statistical significance(P 0.05).Conclusion Curative effect is better than pure Western medicine conservative treatment of adhesive intestinal obstruction with integrated traditional Chinese and Western medicine,greatly reduces the probability of operation,so as to alleviate the suffering of patients.It is worthy of popularization in clinical practice.

Objective To observe the therapeutic effect of combined traditional Chinese and Western medicine in the treatment of severe acute pancreatitis.Methods The patients were randomly divided into two groups,with 60 cases in treatment group and 60 cases in control group.The control group was given conventional Western medicine treatment;treatment group was treated with integrated Chinese and Western medicine treatment method based on control group treatment.The curative effect and adverse reaction of patients were observed.Results After treatment,in clinical improvement symptoms in two groups,the treatment group was better than the control group;the treatment group cure rate and total effective rate was higher than that of the control group.Through χ2 test,the difference was significant between the two groups(P 0.05).Conclusion The combination of occurrence can significantly shorten the course of treatment and reduce the complications in the treatment of acute pancreatitis integrated traditional Chinese and Western medicine.

目的观察消瘤饮治疗胃癌术后由化疗引起的不良反应的临床疗效。方法选择2010年5月至2012年5月该院外科及门诊确诊的胃癌术后患者70例,随机分为消瘤饮加化疗组(试验组)和单纯化疗组(对照组),试验组应用消瘤饮随证加减配合西医化疗35例,对照组为西医常规化疗35例,对比观察疗效。结果在化疗引起的不良反应数量和程度方面,试验组均显著低于对照组(P<0.05)。结论消瘤饮在治疗胃癌术后化疗引起的不良反应方面具有明显的优势,保护机体的重要脏器功能及免疫功能,提高患者生活质量。

Objective:To approach the effect of the treatment of type 2 diabetic patients of kidney Yin deficiency with combine traditional Chinese and Western medicine.Method: Sixty selected standard cases were randomly divided into treatment group and control group,each group with 30 cases.The two groups were both given oral metformin hydrochloride tablet for western medicine therapy,but the prescription for nourishing the Kidney-Yin was added to the therapy for the treatment group.The changes of syndrome efficacy,fasting plasma glucose(FPG),postprandial 2 hours plasma glucose(P2hPG),hemoglobin A1c(HbA1c),and,hyperlipidemiu(TG),total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C) and high density lipoprotein-cholesterol(HDL-C) in serum lipid were observed after 60 days medication.And then treatment efficacy was evaluated.Result:The treatment group comparing with the control group after treatment: the difference of syndrome efficacy was statistically significant(P0.05);the effects of FPG,P2hPG and HbA1c were statistically significant difference(P0.05);the difference of the effects of TG and TC in blood lipid between the two groups was statistically significant(P0.05),but the effects of LDL-C and HDL-C in blood lipid of comparative differences had not statistically significant.Conclusion: Treatment of type 2 diabetes mellitus of Kidney-Yin deficiency with traditional Chinese and Western medicine can effectively improve patient clinical syndrome,reduce blood sugar,and regulate blood lipids.So it was worthy of clinical application.

Objective:To observe the effect of Junzi Fuzheng decoction in enhancing anti-tumor efficacy of cyclophosphamide and reducing its toxicity.Method: Fifty MFC bearing mice models were established and then divided randomly into five groups: control group,cyclophosphamide(CTX) group(30 mg · kg-1),Junzi Fuzheng decoction(high,medium and low dose,20,10,5 g · kg-1) combined with CTX(30 mg · kg-1)groups.There were 10 mice in each group.After 10 days of treatment,all mice were killed and the tumor inhibiting rates and the index of immunological function were observed.Result: The tumor inhibition rate was higher in each Junzi Fuzheng decoction+CTX group than that in control group(P 0.01).The tumor inhibition rate of high-dose and medium-dose Junzi Fuzheng decoction+CTX group was higher than that in CTX group(P 0.01,P 0.05).The indexes of spleen and thymus as well as proliferation of T lymphocytes and nature killer cell activity in CTX group were lower than those in the high-dose Junzi Fuzheng decoction+CTX group(P 0.01,P 0.05).The counting of peripheral white blood cells and bone marrow nucleated cells in CTX group was lower than those in the high-dose and the medium-dose Junzi Fuzheng decoction+CTX groups(P 0.01,P 0.05).Conclusion: Junzi Fuzheng decoction can enhance the efficacy of chemotherapy and reduce its toxicity in the MFC-burdened mice exposed to CTX.

Objective To observe the therapeutic effect of Zhiyi Anquan Yin (Decoction for stopping enuresis) jointed with acupuncture on the infantile nocturnal enuresis (NE). Methods Totally 108 NE children were randomized into Chinese herbal medicine group of 33 cases, acupuncture group of 34 cases, and Chinese herbal medicine plus acupuncture group of 41 cases. The Chinese herbal medicine group was administered decoction of Zhiyi Anquan Yin, 100ml in the morning and in the evening respectively. The acupuncture group was treated with acupuncture at acupoints Guanyuan (CV 4), Zhongji (CV 3), Henggu (KI 11), Guilai (ST 29), Sanyinjiao (SP 6), Shenshu (BL 23), Yaoyan (EX-B7), Shangliao (BL 31), Ciliao (BL 32), Zhongliao (BL 33), Xialiao (BL 34), Weizhong (BL 40). The acupoints of front side and back side were alternatively used every other day, and the needles were retained for 20min each time. The Chinese herbal medicine plus acupuncture group was administered decoction of Zhiyi Anquan Yin and also treated with acupuncture. All three groups were treated for 20 days in succession. The frequency of NE of each week before and after treatment, during the 3-month follow-up, and the overall effect were observed. After the 3-month follow-up, the consolidation rate, gradually cured rate, and recurrence rate of the effective cases were followed up. Results In the Chinese herbal medicine group, 19 cases (57.6%) were effective, in the acupuncture group, 20 cases (58.8%) were effective, while in the Chinese herbal medicine plus acupuncture group, 40 cases (97.6%) were effective. The total effective rate of Chinese herbal medicine plus acupuncture group was significantly higher than that of the other two groups (P0.05). The frequency of NE of the Chinese herbal medicine plus acupuncture group after treatment was significantly reduced (P0.05). After treatment and during the 3-month follow-up, the frequency of NE of the Chinese herbal medicine plus acupuncture group was also significantly lower than that of the other two groups (P0.05). The consolidation rate of the Chinese herbal medicine + acupuncture group after the 3-month follow-up was significantly higher and the recurrence rate significantly lower than those of the other two groups (P0.05). Conclusion Zhiyi Anquan Yin jointed with acupuncture is effective for children NE, and superior to the herbal medicine oral taking or acupuncture treatment only in result.

中医认为,心脏神经官能症是一种气机逆乱之证,气滞心胸为发病关键;气滞血瘀、痰瘀交阻、郁火扰心为本病的病理演变过程;气血亏虚、心神失养为本病最终结局。中医从整体出发,注重辨证,抓住病位和病机进行治疗,标本兼治,常收满意疗效。

对3个磨饮,即四磨饮,五磨饮,六磨汤3方在源流、病机、组方意义及病位等方面的相似与相异的研究显示,3方起源时期为宋明清,时代接近,具有一脉相承的特点,且对此3方的相关记载集中于清代。其病机皆为"百病皆生于气",即由七情不畅、气机郁结所致,而相异则在于气机郁结程度、组方意义及病位不同。对此三方,历代医家多有论述,现代临床亦有很深的研究。

目的:观察中药复方制剂脑心康2号治疗交感神经型颈椎病的临床疗效。方法:将明确诊断的交感神经型颈椎病患者60例随机分为观察组和对照组各30例,对照组给予口服营养神经药物和电针治疗,观察组在治疗组治疗的基础上加服脑心康2号治疗,两组均连续治疗14 d,观察治疗前后积分改善情况、有效率和远期疗效巩固率。结果:两组在积分改善情况、有效率、远期疗效巩固率方面比较,均有显著性差异(P<0.05),观察组疗效优于对照组。结论:脑心康2号治疗交感神经型颈椎病可提高患者的近期及远期临床疗效,值得推广。