目的:系统评价苦参凝胶联合微波治疗宫颈糜烂的临床疗效.方法:计算机检索中国期刊全文数据库(CNKI)、中国优秀硕士/博士学位论文数据库、万方数据库、维普中文科技期刊数据库(VIP)、MEDLINE、EMBASE,查找2000年至2013年发表的有关苦参凝胶联合微波治疗宫颈糜烂的随机对照试验(RCT).按照Cochrane系统评价方法进行筛选,采用Revman 5.2软件进行Meta分析.结果:共纳入7个研究,共计773例患者.Meta分析结果显示:苦参凝胶联合微波治疗宫颈糜烂的手术治愈率明显高于单纯采用微波治疗[OR=2.80,95％ CI(1.95,4.03),P＜0.000 01],且采用苦参凝胶联合微波治疗患者的术后宫颈排液或出血时间较单纯采用微波治疗患者明显缩短[MD=-6.64,95％ CI(-7.23,-6.04),P＜0.000 01].结论:苦参凝胶联合微波治疗宫颈糜烂可明显提高患者的微波手术治愈率,显著缩短患者的术后宫颈排液或出血时间.

Objective Analysis of the influence of division of hierarchical control the intensity of use antibacterial drugs in hospital management of antibacterial drugs. Methods Hospital Division of hierarchical control of antimicrobial use frequency period before and after the use of various antimicrobial drugs(DDDs) were calculated, and the calculation of branches at all levels of the intensity of use of antimicrobial agents, antimicrobial drug use, the strength of all the intensity of use of antimicrobial agents and classified using intensity, and the results were analyzed and compared. Results Our Hospital Division of hierarchical control strength in use before 2012 March the intensity of use of antimicrobial agents for 84.7DDD antibacterial drugs, after the 2012 July for the54.3DDD control. Conclusion The hospital to carry on the division of grading the intensity of use of antimicrobial agents to control hospital use of antibiotics, and help for the management of clinical use of antibacterial drugs.

目的回顾性分析药物性牙龈增生的药物咨询特点和内容，为深入开展药物咨询工作提供参考。方法统计分析2011年至2013年本院药物性牙龈增生的药物咨询记录。结果临床医师、护士、患者均有咨询；咨询涉及药物品种，不良反应的判断和鉴别，影响的相关因素及临床处置四方面的内容。结论药物性牙龈增生临床发病机制不清，需临床药师不断地更新知识，了解文献，汇总分析，服务临床。

Infantile allergic purpura is a typical immune disease with systemic generalized vasculitis as main pathological changes, which could injury skin, gastrointestinal tract, kidneys, joints, and even more such as heart and brain. Western therapy based on symptomatic and hormonal treatment for the disease shows limited applicability and remarkable side effect. This study designed to observe efficacy of traditional Chinese herbal medicine combined with western therapy on infantile allergic purpura through perspective of immunology, in which76 cases of infantile allergic purpura patients were randomly divided into control group of 38 cases which were treated with conventional western therapy and observation group of 38 cases which were given oral Chinese herbal medicine on the basis of conventional ways. Fasting venous blood of each patient was extracted and detected for the indexes of immunoglobulin, complement, and cells secrete factors. We found that there was no significant difference(P 0.05) between groups in serum immunoglobulin, complement, and cells secrete factor levels before the treatment. After treatment, indexes of IgA, IgE, C3, TNF-α, IL-4, IL-6, IL-10 and IL17 level were significantly reduced(P 0.05), and all of them in observation group were significantly lower than that of control group(P 0.05);but IL-12 level was significantly increased(P 0.05) while observation group got the higher level(P 0.05); there was no significant difference in indexes of IgG, IgM, C4 and IFN-γ between groups. Our research indicated that the therapy combined with traditional Chinese and western medicine could balance humoral and cellular immunity function through adjust inflammatory factors of pediatric allergic purpura patients, which contributes to inflammatory remission and excision.

OBJECTIVE:To evaluate the effects of pharmacy trusteeship model in pharmacy management of our hospital.METHODS:The pharmacy trusteeship model of our hospital was introduced in respect of the responsibility of the staff,the establishment and implementation of rules and regulations,the supply and management of drugs,finance management,etc. RESULTS CONCLUSIONS:Through the implementation of pharmacy trusteeship model,in the field of staff responsibility,pharmaceutical trading trusteeship enterprises were in charge of drug purchase,distribution,dispending,charge to an account and personal assignment,etc.;professional pharmaceutical staff were appointed for monitoring and guidance in our hospital. In the field of the establishment and implementation of rules and regulations,our hospital consulted with pharmaceutical trading trusteeship enterprises to develop relevant management rules and carried out effective assurance measures. In the field of drug supply and management,responsible person in pharmacy of our hospital drafted the range and number of standby base drugs in clinical departments according to the characteristics of drug use,and pharmaceutical trading trusteeship enterprises supplied common drugs in the clinic. In the field of finance management,our hospital provided special drugs account regularly,and pharmaceutical trading trusteeship enterprises paid relevant fees;both of them managed the special drugs account. Not only could it reduce the management costs of drugs,but also could it further regulate the pharmacy management.

OBJECTIVE To evaluate the effects of Kutai capsule on hormone level and perimenopausal syndrome in the menopausal rats/mice.METHODS 110 female rats and 100 female mice were respectively randomly assigned to the following conditions:negative control group,Chinese herb group and positive control group.The rats or mice in Chinese herb group were fed Kuntai capsules according to 5.0,2.5,1.25 g·kg-1 administered once a day for 4 weeks,in negative control group werefed distilled water and in positive control group were fed positive control drug.RESULTS Kuntai capsules had lower effect on follicle-stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T)and had higher effect on estradiol(E2)in the menopausal rats(P0.05).Kuntai capsules had no significant effect on hormone level in ovariectomized mice(P0.05),but increased the uterus weight(P0.01).Kuntai capsules could antagonize the sweat secretion induced by pilocarpine in paws of rats(P0.01).The sleep time could be extended by Kuntai capsules(P0.05).CONCLUSION Kuntai capsules improved hormone level and effectively relieve perimenopausal syndromes,but had no effects on hormone level in ovariectomized mice.

<正>银杏叶提取物经过多年的临床应用被证明对老年性疾病治疗效果显著[1]。本研究通过对老年性痴呆大鼠注射银杏叶提取物,并与西药脑复康进行疗效对比,以探讨其对大鼠学习记忆能力的影响。1材料与方法

<正>对乙型肝炎后肝硬化腹水,目前西医治疗主要根据患者的情况适当限制盐、水的摄入,使用抗醛固酮药物及利尿剂,酌情补充白蛋白及血浆,必要时,腹腔穿刺放液。而中医对此的治疗方法较多,但疗效不满意。我院采用中西医结合的方法治疗该病,西医方面主要保肝、抗病毒及对症支持治疗,中医中药方面运用健脾益气、化瘀利水法取得了一定的临床疗效,现报告如下。

quinolone antibacterial drugs has been widely used, these drugs can quickly kil the bacteria, but, this class of drugs has a huge derivatives library, can develop a lot of quinolones, can according to the different characteristics of the development of effective antibacterial drugs bacteria. According to the pharmacological effects of quinolone, analysis of the characteristics of bacterial genetic molecular mechanism, effective development of quinolone derivatives, to lay the foundation for development of new generation of quinolones.

<正>颈性眩晕在临床多见于中老年人,其病因多与肾精不足、痰浊蒙蔽有关。近年来,笔者采用中药配方治疗颈性眩晕患者,取得了较好疗效,现将报告如下。1临床资料1.1一般资料共观察治疗80例,均为本院门诊或住院的颈性眩晕患者,随

目的探讨白藜芦醇对帕金森病模型大鼠神经细胞黏附分子mRNA的影响。方法采用6-OHDA纹状体内注射制作帕金森病模型大鼠,将造模成功大鼠随机分为模型组和白藜芦醇(20mg/kg/d)治疗组,并设假手术组及正常组,每日口服给药一次,连续10周,给药过程中每周进行一次行为学检测,白藜芦醇治疗后检测大鼠黑质细胞神经细胞黏附分子mRNA的变化。结果白藜芦醇能改善大鼠的旋转行为,模型组神经细胞黏附分子mRNA低于白藜芦醇组(P<0.05)。结论白藜芦醇对帕金森病大鼠产生保护作用,其机制可能与提高神经细胞黏附分子mRNA有关。

目的:观察头孢克肟颗粒加中药组方治疗中轻型小儿喘息性支气管炎的临床疗效。方法:将76例喘息性支气管炎患儿随机分为两组,对照组30例,配合中药治疗组46例。两组常规予以头孢克肟颗粒抗感染,配合抗病毒、吸氧、雾化等处理,治疗组在上述综合治疗基础上,加用中药汤剂,每日2次。观察两组治疗前后喘息缓解、喘鸣音、咳嗽消失时间。结果:治疗组气促缓解、喘鸣音、咳嗽消失时间较对照组缩短(P<0.05);两组治愈率有显著性差异(P<0.05)。结论头孢克肟颗粒加中药组方是佐治中轻型小儿喘息性支气管炎的安全有效方法之一。