Objective:To compare the effects of transfusion for two AIHA patients who posses specific anti-D autoantibody and were transfused with red blood cells with perfect match or imperfect match and provide useful information for further study.Method:Erythrocyte antibody determinacy test,direct antiglobulin test(DAT),microcolumn gel test were used to screen matched red blood cells for transfusion for two AIHA patients.The level of hemoglobin,reticulocyte ratio,bilirubin and dissociated hemoglobin were measured before and after transfusion.Result:Our data showed that there was no transfusion reaction in AIHA patients posses specific anti-D autoantibody when transfused with perfect or imperfect matched red blood cells.Conclusion:AIHA patients with specific anti-D autoantibody could be transfused the RhD positive blood with weaker agglutination intensity when it is necessary.

OBJECTIVE:To analyze the incidence of coronary artery disease (CAD) and outcome of patients with left ventricular noncompaction (LVNC).METHODS:Fifty-one patients with LVNC evaluated by echocardiography and/or cardiac magnetic resonance (CMR) from January 2006 to August 2010 were retrospectively reviewed. Coronary angiography or MDCT was performed for detecting coronary artery disease. Predictors of the cardiac events were analyzed by Cox regression analysis.RESULTS:There were 31 LVNC patients without CAD and 20 LVNC patients with CAD including single vessel coronary disease in 9 cases, double vessel coronary disease in 3 cases, three vessel coronary disease in 5 cases and left main coronary disease in 3 cases. Coronary artery bypass graft and percutaneous coronary intervention (PCI) were performed in 4 patients. Compared to LVNC patients without CAD, mean age (P = 0.008), incidence of hypertension (65.0% vs. 19.4%, P = 0.001), diabetes mellitus (40.0% vs. 12.9%, P = 0.026) and hyperlipidemia (55.0% vs. 25.8%, P = 0.035) were significantly higher while NT-proBNP level was significantly lower (P = 0.049) in LVNC patients with CAD. Incidence of major cardiac events was similar in LVNC patients with or without CAD. LogNT-proBNP is the independent prognostic factor for adverse cardiac events in patients with LVNC (HR 3.993, 95%CI 1.140 - 13.988, P = 0.030).CONCLUSIONS:Coronary artery disease is common in patients with LVNC and associated with traditional risk factors for CAD. Poor prognosis is associated with increased NT-proBNP but not with CAD in this patient cohort.

<正>本院自1980年代开始,开展造血干细胞移植。在患者行异基因造血干细胞移植前对供者与受者进行ABO血型及Rh血型鉴定,自2003年2月开始我院使用Rh分型卡进行C、c、E、e抗原鉴定。由于卡上带有K抗原鉴定孔,因此在记录Rh血型的同时,观察并记录了K抗原在人群中的分布情况。至今共检测912例,发现1例K抗原阳性者,为造血干细胞移植正常供者,进一步对其进行家系调查,现报道如下。

输注血小板是各类血液病治疗过程中的常用支持疗法,在预防和治疗因血小板减少导致的出血中,具有重要临床意义.随着临床上对血小板输注后效果的日益关注,临床医生会为某些输注血小板后治疗效果欠佳的患者申请配型.

<正>真性红细胞增多症(polycythemia vera,PV)简称"真红",是1种获得性,源于造血干细胞的克隆性疾病,其特征为红细胞(RBC)造血异常增生,红系祖细胞对红细胞生成素高度敏感和非依赖[1]。PV患者最常用的疗法之一是放血治

干细胞移植是用正常的干细胞取代患者异常造血细胞,以根治疾病的一种治疗手段.最近我院发现ABO血型次要不合外周血干细胞移植后早期血型完全改变1例,目前国内尚未见报道,特报道如下.

Objective: To explore the blood component selection and transfusion for patients undergoing major ABO incompatible allogenic stem cell transplantation.Methods: ABO blood group was identified in recipients and donors of allogenic stem cell transplantation, and the blood component and amount, the time for RBC blood group transversion and stem cell engraftment were analyzed in 28 patients undergoing ABO incompatible transplantation. Results: Compared with patients undergoing ABO compatible transplantation, the time for blood group transversion was significantly prolonged (P 0.01 )and more RBC transfusions were required in 15 patients undergoing major ABO incompatible transplantation (P 0.05 ). And the amount of RBC transfusions was also higher in 13 patients undergoing minor ABO incompatible transplantation (P 0.05 ). The time for stem cell engraftment and the platelet concentrates transfusions were not significantly different between patients undergoing ABO compatible and incompatible transplantation.Conclusion:RBCs and platelet with me not destroyed by the recipients′ serum agglutinin were required for patients undergoing ABO incompatible allogenic stem cell transplantation.

造血干细胞移植前,对供受者双方要进行血型鉴定.ABO血型不合可以进行干细胞移植,移植期间及移植后患者血型的变化,不仅是红细胞血型标志发生了改变,而且在输血疗法中也应引起注意.笔者对28名ABO血型不合的干细胞移植患者的血型转变情况作了观察.