目的:探讨近视与双眼视功能状态以及用眼时间的关系.方法:对广州市花都区219名10～12岁的学生进行纵向队列研究,研究对象均于2016年基线检查时进行了眼部生物测定、散瞳下自动验光、主观验光、配镜,并在戴镜2周后测量散瞳验光结果,2017年11月再次重复上述检查.同时做调查问卷收集户外、户内活动时间,进一步比对.结果:219名学生1年后近视度数加深值为-1.05±0.44(P＜0.001),眼轴长度1年后增长0.44±0.31,两者呈正相关(P＜0.001);近视度数与调节滞后、调节幅度有相关性,同时与周一至周五户外活动时间呈负相关.结论:近视加深速度与调节滞后、调节幅度有关.在用眼时间方面,户外活动时间越短,近视加深越快;户内活动时间越长,近视加深越快.

目的 了解广州市5 ～17岁儿童近视流行的客观状况,为评价标准对数视力表筛查视力不良的有效性提供依据.方法 采用分层随机整群抽样的方法并经家长知情同意,对广州市6 580名学龄前儿童和中小学生进行远视力表筛查,对其中视力＜5.0的3 712名学生进行散瞳验光检查.结果 散瞳前儿童的视力不良检出率为56.5％,视力不良的轻度、中度和重度构成比分别为14.9％,27.7％和57.4％;散瞳后的近视检出率为34.6％,远低于散瞳前的视力不良检出率(x2=633.549,P＜0.01).近视的轻度、中度和高度的构成比分别为65.6％,31.0％和3.4％;低年龄组视力不良学生主要以远视为主,随着年龄的增长逐步演变为以近视居多,而屈光正常属功能性近视的比例为11.4％.结论 5～17岁儿童近视患病率符合传统的年龄规律,远视力表筛查结果不能全面客观反映学生近视流行的真实状况,应修订现行的学生视力筛查方法和标准.

[目的]比较配戴治疗性角膜接触镜(TCL)前后Tono-pen眼压计测量角膜病变患者眼压测量的差异,分析治疗性角膜接触对Tono-pen眼压计测量值的影响.[方法]连续纳入2012年4月至2012年10月我院就诊的33例(33眼)角膜病变患者,包括大泡性角膜病变11眼、眼化学伤8眼、单疱病毒性角膜炎5眼、继发性青光眼4眼、前部角膜营养不良2眼、穿透性角膜移植术后2眼、复发性胬肉l眼.应用Tono-pen眼压计测量患者未配戴TCL和配戴TCL两种状态下的眼压,每种测量方式各重复测2次.用组内相关系数ICC计算每一种测量方法的重复性,计算重复测量间差异的95％可信限;配对t检验比较两种眼压测量方法的差异,计算差异的可信限95％LoA,并绘制Bland-Altman散点图.[结果]Tono-pen眼压计直接重复测量的ICC为0.986,两次测量的平均差值为(0.42± 1.98) mmHg,95％可信限为-4.30 ～ 3.46 mmHg,其中90.9％的测量差值≤3 mmHg;配戴治疗性角膜接触镜后重复测量的ICC为0.983,两次测量的平均差值为(0.12±2.19)mmHg,95％可信限为-4.46 ～ 4.22 mmHg,90.9％的测量差值≤3 mmHg.配戴治疗性角膜接触镜后Tono-pen眼压测量值平均减小(0.68±3.39)mmHg,差异无统计学意义(P=0.257),两种测量结果的一致性系数ICC为0.959,差值的95％可信限为-7.32～5.96 mmHg,其中70％测量的差值≤3 mmHg;在平均眼压＜21 mmHg的患者中,82.4％的测量差值≤3 mmHg,在平均眼压≥21 mmHg的患者中,56.3％的测量差值≤3 mmHg.[结论]Tono-pen眼压计测量角膜病变患者的眼压有较好的重复性,配戴治疗性角膜接触镜对测量的重复性和总体的测量均值无影响.但配戴角膜接触镜前后眼压测量值存在一定程度的差异,高眼压者比正常眼压者的差异大,临床应用时应对测量结果进行客观的评价.

为贯彻落实《中华人民共和国科学技术普及法》和国家"十二五"科学和技术发展规划》和《全民科学素质行动计划纲要(2006-2010-2020年),响应政府调动社会力量开展科普工作,加强科普教育基地建设、推动科普事业发展的号召,广泛开展形式多样的群众性和社会性眼科科普活动,让眼科学的科技成果惠及广大人民群众,营造"讲科学、学科学、爱科学、用科学"的良好社会氛围,本科普基地利用自身丰富的眼科科普资源,继续投入经费完善科普展厅、科普画廊等设施建设,以期提高广大市民科学素质,为建设幸福广东作出积极贡献。

Objective To observe the changes of central anterior chamber depth(ACD) and lens' position after phacoemulsification and intraocular lens(IOL) implantation in the eyes with filtered primary angle closure glaucoma(PACG) in comparison with cataract cases.Design Comparative case series.Participants PACG group included sixteen eyes(16 patients) with successful filtration surgery(IOP≤21 mm Hg) that required cataract surgery.The age-and gender-matched control group included 17 eyes(17 patients) with simple senile cataract.Method Anterior segment optical coherence tomography(AS-OCT) was used to measure the anterior segment parameters pre-and 1 week post-phacoemulsification combined with IOL implantation in both groups.Then the AS-OCT parameters were compared between the PACG group and normal control group.Main Outcome Measures Anterior chamber depth(ACD),anterior chamber width(ACW),lens thickness(LT) and crystalline lens rise(CLR).Result Compared with the control group,ACD(P0.01) was significantly shallower,LT(P0.01) was significantly thicker and CLR(P=0.04) was larger in the PACG group before cataract surgery.There were no significant differences between groups in ACD,ACW and CLR(P all0.05) after cataract surgery.After cataract extraction,ACD increased(1.58 mm vs.0.98 mm),while CLR decreased(1.58 mm vs.1.06 mm) significantly in the PACG group than that of control group(P0.01).Conclusion Filtered PACG still has shallow ACD because of lens thickened and forwards.Phacoemulsification and IOL implantation can deepen ACD and improve the lens position in filtered PACG.

The noises,which come from the 3D Point Cloud data obtained by the Heidelberg Retina Tomograph (HRT),can be smoothed effectively by a bilateral filtering algorithm. This algorithm can retain the graph feature information while denoising,but the execution time of this algorithm increases greatly with the increase of the iteration number,so that this algorithm can not be applied to the diagnostic practice. The mean neighborhood method can also smooth the graph through the average value processing to a point's Z coordinate of a certain neighborhood,and selecting different weights according to the distance from the target point,but the effect is not better than using the bilateral filtering algorithm. So this paper presents the mean neighborhood method to perform preprocessing by bilateral filtering denoising. We find our method can significantly reduce the computing time.

Objective To compare the difference and repeatability between anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscope (UBM) in measuring central anterior chamber depth (ACD). Methods Twenty-nine patients (32 attacked eyes and 23 unaffected fellow eyes) with acute primary angle closure glaucoma (APACG) and 41 patients (74 eyes) with chronic primary angle closure glaucoma (CPACG) were included in this study. AS-OCT and UBM were used to measure the ACD of these APACG and CPACG subjects. Pair sample t test and correlation analysis were introduced to analyze the difference and correlation of the ACD values between the 2 instruments. ACD of one complete randomly selected eye was measured 10 times by the above 2 instruments, respectively, and the repeatability of 2 instruments was analyzed. Results There was no significant difference in ACD values of attacked eyes of APACG between AS-OCT and UBM. In unaffected fellow eyes and CPACG eyes, the ACD values measured by AS-OCT were deeper than that measured by UBM[ (1.923±0.287) mm vs (1.860±0.243) mm, (2.017±0.054) mm vs (1.913±0.052) mm, both P=0.012]. Positive correlation between AS-OCT and UBM in measuring ACD was found (r=0.928, P<0.001). The coefficient of variation of ACD was 0.66% as measured by AS-OCT, and 0.82% as by UBM. Conclusions The ACD measured by AS-OCT can be deeper than that by UBM. Excellent correlation is found between AS-OCT and UBM measurements. AS-OCT appears to be more repeatable in measuring ACD than UBM.

Objective To analyze the relationship among parameters of healthy human eye anterior segment structure detected by anterior segment optical coherence tomography (AS-OCT), and to explore the effect of age on these parameters. Methods AS-OCT was performed in 211 healthy people (211 eyes) to measure the parameters of anterior segment structure, including anterior chamber depth (ACD), anterior chamber horizontal diameter (ACHD), anatomy anterior chamber depth (AACD), lens thickness (LT), ciliary band length (CBL) , lens position (LP) and iris thickness (IT). These parameters were compared between men and women. Relationship among the parameters was analyzed, and effect of age on anterior segment structure biometric values was evaluated. Results The values of ACD, ACHD, AACD, CBL, IT and LP were significantly higher in male than those in female[ACD: (2.87±0.38) mm vs (2.66±0.40) mm; ACHD: (11.73±0.43) mm vs (11.53±0.36) mm;AACD: (3.09±0.19) mm vs (3.00±0.19) mm;CBL: (0.20± 0.09) mm vs (0.17±0.09) mm;iT: (0.36±0.08) mm vs (0.34±0.08) mm; LP: (5.11±0.26) mm vs (4.91± 0.28) ram; all P<0.05]. The value of LT was not significantly different between men and women (P=0.955). Age had no significant effect on AACD, IT, LP and CBL (all P>0.05). ACHD was negatively correlated with age (r=-0.148, P=0.032). LT was positively correlated with age (r=0.646, P=0.000). LT was negatively correlated with ACD (r=-0.714, P=0.000). LT had no significant effect on LP using regression analysis. Conclusions The anterior segments biometric structure of female is narrower than that of male. With aging, the narrowing of ACD is resulted from LT increment. And LP of healthy eyes does not change with aging and LT increment.

Objective To assess central corneal thickness(CCT)and anterior chamber depth (ACD) measurements with anterior segment optical coherence tomography (AS-OCT)comparing with A-scan ultrasonography (A-scan US).Methods 54 eyes of 33 normal subjects were enrolled in the study.CCT and ACD were measured using AS-OCT and A-scan US.The measurements of two instruments were analyzed using paired t test,Pearson correlation and Bland-Altman plot,respectively.Results The CCT of AS-OCT and A-scan US were 524.41± 23.24 microm and 513.37± 22.7 microm,respectively.The CCT values measured by A-scan US were significantly greater than AS-OCT, paired difference was 11.04± 5.10 microm (t =15.906, P =0.000).There were a significantly correlation between CCTs value of two instruments (r =0.976, P =0.000). The 95% LoA (95% Limts of Agreement)was -21.03 microm to -1.04 microm.The width of 95% LoA was 28 microm,3.81% of the average pachymetry reading.The ACD of AS-OCT and A-scan US were 2.89± 0.29 mm and 3.18 ± 0.26 mm,respectively.The ACD values measured by AS-OCT were significantly greater than A-scan US, paired difference was -0.29± 0.17 mm(t =-12.052, P = 0.000).There were a significantly correla-tion between CCTs value of two instruments(r=0.803 ,P=0.000).The 95% LoA was -0.63 mm to -0.06 mm.The width of 95% LoA was 0.57 mm, 19.72% of the average A-scan reading.Conclusion CCT and ACD measured by AS-OCT were highly correlated with that from ultrasound pachymetry.ln comparison with measurements of A-scan,CCT value of AS-OCT was lower,and the ACD was deeper.However,ACD readings by AS-OCT and A-scan were consistently less than that of CCT.

Objective To observe the damage of retinal nerve fiber layer thickness(RNFLT)in chronic primary angle closure glaucoma (CACG)and analyze its effect factors.Method Sixty-four eyes of 36 patients with CACG and 82 eyes of 82 normal subjects were examined by optical coherence tomography(OCT).The RNFLT were compared between patients with CACG and normal persons.The RNFLT were also compared among eyes without peripheral anterior synechiae(PAS) ,PAS extent less then 2 quadrants and PAS more than 2 quadrants in CACG patients.The correlationship between mean RNFLT and MD values of visual field in CACG were analyzed.Result There was significant difference of mean RNFLT between CACG (80.61±23.96)μm and normal controls(103.73±9.92)μ m(P ＜0.05).The differences of RNFLT among CACG eyes without PAS(98.46:1:12.34)μm,PAS extent less then 2 quadrants(93.93±14.78)μm and PAS more than 2 quadrants (69.78±23.82)μm were significant (P ＜0.05).There was positive correlation between average RNFLT of CACG and visual field(MD)(r = 0.652,P ＜0.001).ConclusionThe RNFLT of CACG is significantly thinner than normal controls.The RNFLT decreases and the mean visual field defects increase gradually along with the extension of PAS and progress in CACG. Key words: Optical coherence tomography,Glaucoma/closed angle,Retina nerve fiber layer

【Objective】 To study the relationship between structure of anterior segment tissues and open angle(AA) in normal subjects.【Methods】 A total of 211 eyes from 211 normal subjects were enrolled,whose anterior chambers and lens were scanned using anterior segment optical coherence tomography(AS-OCT).The measuring items included AA,anterior chamber depth(ACD),anterior chamber horizontal diameter(ACHD),anatomical anterior chamber depth(AACD),ciliary band length(CBL),iris thickness(IT),lens thickness(LT),lens position(LP) and lens anterior apex position(LAAP).The relationship between the 8 biometric parameters and AA was analyzed using linear correlation,respectively.【Results】 The mean of AA was(40 ± 17)°,with(44 ± 18)° in male,and(37 ± 16)° in female.The difference of AA between male and female was statistically significant(t = 2.893,P = 0.004).There was significant correlation between AA and ACD(r = 0.721,P = 0.000),LT(r =-0.545,P = 0.000),CBL(r = 0.615,P = 0.000),LAAP(r =-0.717,P = 0.000),LP(r = 0.557,P = 0.000),and ACHD(r = 0.175,P = 0.011).There was no significant correlation between AA and AACD(r = 0.130,P = 0.059),IT(r = 0.129,P = 0.061).【Conclusion】 The AA of females was narrower than that of males.In normal subjects,the most important factors which determine AA are the lens,the location of the peripheral iris and ciliary body.

Objective To evaluate and compare the anterior chamber inflammatory response after phacoemulsification with implantation of foldable intraocular lens and after extracapsular cataract extraction (ECCE) with implantation of un-foldable intraocular lens. Methods The aqueous protein concentration in 37 eyes of 32 patients after ECCE an 64 eyes of 60 senile patients who underwent phacoemulsification with intraocular lens implantation were examined using a laser flare-cell meter.Quantitative measurements of anterior chamber aqueous protein concentration were performed preoperatively and on day 1, 7,30,and 90 after surgery.Results Aqueous flare mean photon counts in patients after ECCE and those after phacoemulsification were 7.18±1.38 and 6.94±2.34 before surgery (P0.05);and increased to 32.60±11.91 and 26.27±10.21 on day 1 after surgery (P0.05);then decreased to 19.83±6.46 and 13.96±6.44 on day 7 after surgery (P0.05);13.25±4.01 and 9.07±2.67 on postoperative day 30 (P0.05);eventually,the counting decreased to 9.53±3.25 and 7.16±1.89 on day 90 after surgery (P0.05).In eyes with ECCE,highly statistically significant differences were found between preoperative flare values and those on days 1,7,30 and 90 after surgery while no statistically significant differences were found between preoperative flare values and those on days 90 after surgery in eyes after phacoemulsification.Conclusions For age-related cataract patients after ECCE,a more severe disorders of BAB was observed and a relative longer time for reestablishment of the blood-apueous barrier was required,while a short period after phacoemulsification.

Objective To detect changes in retinal nerve fiber layer (RNFL) thickness in the first 6 months after acute primary angle closure glaucoma (APACG) attack. Methods Twenty-four subjects with a single unilateral APACG attack and 55 eyes from 55 normal subjects were included in our study. The RNFL thickness was accessed in both eyes using optical coherence tomography (OCT) within 3 days, 2 weeks, 1, 3 and 6 months after intraocular pressure(IOP) control. The RNFL thickness was compared within the attacked eyes and the fellow eyes. And at the first and last visits, the RNFL thickness was compared between normal controls and2unaffected fellow eyes. Results Comparing with the unaffected fellow eyes, the mean RNFL thickness for the attacked eyes increased significantly within 3 days ( 121.49±23.84 )μm after IOP control (P＜0.01 ). At 2 week (107.22±24.72 )μm and 1 month (93.58±18.37)μm, there was no difference between the affected eyes and the unaffected fellow eyes for the mean RNFL thickness(P=0.31 and 0.08). At 3 months (84.10±19.89)μm and 6 month (78.98±19.17)μm, the mean RNFL thickness for the attacked eyes decreased significantly (P＜0.01 ). There were significant differences for the changes of RNFL thickness in the attacked eyes among the 5 visits (P＜0.01～0.048 ). No significant difference was demonstrated comparing of the mean RNFL thickness for unaffected fellow eyes with those of the normal subjects at first and last visits(P=0.13～0.98 ). Conclusions After an APACG episode, the RNFL thickness of attacked eyes significantly increased, and then decreased over time in the first 6 months after IOP control.

Objective To assess reproducibility of anterior segment optical coherencetomography (AS-OCT)to quantify the anterior chamber angle(AA).Methods 23 eyes of 30 subjects were enrolled.Anterior champer angle was scanned using AS-OCT,and the 500μm(AA-500 μm)and 750μm(AA-750μm)temporal anterior champer angle were measured by two ophthalmologists,respectively.And one observer repeatedly measured its in two different times.Analyzing the reproducibility with intraclass correlation coefficient(ICC)and 95%Limts of Agreement(95%LoA).Results The difference in AA-500μm and AA-750μm measurements between two observers were not significant(all P＞0.05),and its were also no significant difference between the first and the second measurement for same observer(all P＞0.05).The 95%LoA of intraobserver of AA-500μm and AA-750μm were-5.441 to 5.281 degrees and-7.313 to 6.020 degrees,respectively.The ICC server of AA-500μm and AA-750μm were-6.098 to 5.098 degrees and-7.877 to 5.423 degrees,respectively.The ICC of interobserver of AA-500μm and AA-750μm were 0.925 and 0.887,respectively.Conclusions This study demonstrated that the AS-OCT measurements for AA showed a high degree of reproducibility.Thus,AS-OCT can be used to quantitative measurement AA in the clinic.

Objective To evaluate the clinical value of anterior segment optical coherence tomography (AS=OCT) on measuring the biometric structures of anterior segments of eyes in normal subjects.Methods One hundred and five eyes of 105 normal subjects were enrolled,whose biometric structures of anterior segments were measured using AS-OCT.The measuring items included central cornea thickness(CCT).anterior chamber depth (ACD),lens thickness (LT) and anterior chamber horizontal diameter(ACHD). The differences of biometric structures of anterior segments between genders were compared.The effect of age on the biometric structures of anterior segments was analyzed using linear correlation and regression.Results The mean value of CCT,ACD,LT and ACHD were(525.16±30.58)μm,(2.97±0.32)mm,(4.21±0.43) mm and(11.68±0.35)mm.respectively.The mean ACD of females was(2.87±0.33)mm,which was significantly shallower than that of males(3.07±0.29)mm (P=0.001).The CCT was (525.32±31.21)μm in females and(525.00±30.23)μm in males(P=0.957),LT was(4.26±0.42)mm in females and(4.16±0.43)mm in males(P=0.250),and ACHD was(11.64±0.32)mm in females and(1.73±0.38)mm in males(P=0.217),which showed no significant difference between genders.Age had no significant effect on CCT(r=-0.067,P=0.514)and ACHD(r=-0.137,P=0.179).There were significant negative correlation between age and ACD (r=-0.570,P=0.000),and positive relationship between age and LT(r=-0.806,P=0.000).The analysis showed decreases of ACD with age by 10(m per year,and the increase of LT with age by 19(m per year,respectively.Conclusion CCT,ACD,LT and ACHD of normal subjects can be measured quantitatively and accurately by AS-OCT. The biometric structures of anterior segments of females were shallower than that of males.With age,ACD become shallower,while LT increase in normal subjects.

Objective To investigate the relative size of functional filtering bleb obtained by the computer image analysis system and the relationship between the relative bleb size (RBS) and the intraocular pressure (IOP). Methods Functional filtering bleb image was obtained by slit-lamp camera system. Both quantitative analysis of the RBS with image analysis system (EPCO2000 Software) and consistency of analysis were conducted. IOP was measured by Goldmann tonometer. A linear regression analysis of RBS and IOP was carried on. Results Forty-three eyes of 36 patients were involved in this study. The average follow-up time post operation was 2.5± 2.9 (0.5 to 11.0) years and the average value of IOP was 13.0± 3.6 (5.0～19.7) mmHg. The average of RBS by Image Analysis System was 0.44± 0.27 (0.10 to 1.44 ).Consistency analysis showed that the intraclass correlation coefficient (ICC) value was 0.984 (P <0.01 ) by one same observer and the ICC among three different observers was 0.971 (P<0.01). Correlation coefficient(r) of RBS and IOP value was -0.713 (P <0.01), and the regression equation was: Y=17.043-9.249X. Conclusion Image analysis system (EPCO2000 software ) could be a more accurate measurement of RBS after trabeculectomy. The bigger the functional filtering bleb was, the lower the IOP.

Objective To investigate the early influence nf trabeculectomy on tear film and epithelial cells of ocular surface.Methods Twenty-six patients (36 eves) with glaucoma underwent trabeculectomy with adjustable suture,and with or without use of intraoperative mitomycin-C(MMC) undel conjunctiva and sclera were included from March 2006 to May 2007.Routine ocular examinations and ocular surface examina- tions,including Schirmer I test,break-up time,fluorescein staining,rose bengal staining,and conjunctival impression cytology,were conducted preoperatively and 1 month postoperatively.Results Compared with normal controls,troth postoperative and preoperative BUT were significantly shortened,and FL,RB scores, conjunctival Nelson classification significantly higher,and goblet cell density was significantly decreased in glaucomatous patients.No statistically significant difference of Sit were observed between the patients and the normal controls.There were no statistically significant difference of Sit,BUT,FL and RB scores between pre- operation and 1 month postoperation.Postoperative conjunctival Nelson classification was significantly higher than preoperative level,and goblet cell density was significantly lowered.There were no significant difference of Slt,BUT,Nelson classification and goblet cell density between 0.25 mg/ml MMC group and the control preoperatively and 1 month pnstoperatively.The FL and RB scores of the control group were significantly high- er than MMC group postoperatively.Conclusion There may be some influence of trabeculectomy on tear film stability and ocular surface epithelium,which is manifested by teat film unstability,epithelial staining, conjunctival squamous metaplasia,and goblet cell density decrease 1 month postoperatively.These may not be related to use of low concentration of MMC in operation.

目的 探讨一种新的超声振动模式-扭动模式(Torsional)用于白内障超声乳化吸除的有效性安全性.方法 病例来自中山大学中山眼科中心,诊断单纯性老年白内障对其进行随机分组并行超声乳化白内障吸除,一组选用扭动模式,而另一组选用常规模式,记录术中所使用的超声时间(Ultrasound Time,UST)及超声能量(Cumulative Dissipated Energy,CDE),并比较术后角膜水肿程度、角膜厚度、术后的最佳矫正视力及角膜内皮细胞的丢失率.结果 术中所使用的超声时间及超声能量比较,扭动模式组较常规模式组低,对于1、2、3、4级核,平均UST扭动模式组为8.32,18.45,29.48和48.39秒,而常规模式组为10.25,25.14,36.45和61.44秒;扭动模式组平均超声能量为0.94,3.13,7.47和14.08,常规模式组为1.25,4.18,8.59,16.51,之间的差异具有统计学意义.术后的平均最佳矫正视力比较,术后1天及术后7天扭动模式组较常规模式组高,而术后1月观察差异不具有统计学意义.角膜水肿及平均角膜中央厚度比较,术后1天及7天扭动模式组较常规模式组角膜水肿轻,术后30天比较它们之间的差异不具有统计学意义.术后7天及30天平均角膜内皮细胞计数比较,扭动模式组较常规超乳模式组高,丢失率低.结论 扭动模式超声乳化白内障吸除较传统超乳模式相比,是一种高效安全的超声乳化振动模式,较传统模式相比可以减少术中的超声时间及超声能量,并减少对眼内组织特别是角膜内皮细胞的损伤。

[目的]探讨正常人晶状体随年龄的增长对眼前段轴向空间结构的影响.[方法]采用眼前段光学相干断层扫描仪(AS-OCT)测量正常人105例(105只眼)前房深度(ACD)和晶状体厚度(LT);比较它们性别间的差异,采用直线相关与回归分析方法分析年龄与ACD、LT的相关关系.[结果]正常人ACD、LT的平均值分别为:2.97(S=0.32)mm、4.21(S=0.43)mm.女性ACD为2.87(S=0.33)mm比男性3.07(S=0.29)mm浅(P=0.001);LT性别间差异无统计学意义(P=0.250).ACD与年龄负相关(r=-0.570,P=0.000),LT与年龄正相关(r=0.806,P=0.000).ACD随年龄的增加每年变浅8 μm(P=0.000);LT随年龄每年增厚21 μm(P=0.000).晶状体随年龄向玻璃体腔方向扩张的速度存在性别差异(P=0.000),男性13 μm/year,女性7 μm/year.[结论]女性ACD比男性浅,正常人随着年龄的增加,ACD逐渐变浅,LT厚度逐渐增加.女性LT的增加使ACD更趋于变浅,而男性则较多向玻璃体腔扩张.

目的 探讨眼前段光学相干断层扫描仪(AC-OCT)检测前房深度(ACD)和晶状体厚度(LT)的一致性与可重复性.方法 对30例受试者(30只眼)的中央前房和晶状体,采用ACOCT分别由测量者甲和乙,以及测量者甲在两个不同的时间点进行水平方向扫描;对其中的10例受试者(10只眼)的中央前房和晶状体水平方向扫描重复10次.采用类内相关系数(ICC)和变异系数(CV)作为评价测量的一致性,采用变异系数(CV)作为评价测量的可重复性.结果 ACD和LT的平均值分别为(3.16±0.27)mm和(3.90±0.26)mm.测量者间ACD和LT的ICC值分别为0.996(F=499.347,P=0.000)和0.996(F=539.069,P=0.000);变异系数的平均值分别为0.47%±0.24%和0.37%±0.20%.测量者内ACD和LT的ICC值分别为0.999(F=2039.611,P=0.000)和0.999(F=1654.961,P=0.000);变异系数的平均值分别为0.18%±0.22%和0.19%±0.16%.10例受试者(10只眼)的ACD及LT扫描10次的变异系数平均值分别为0.39%±0.12%和0.30%±0.14%.结论 ACOCT测量ACD和LT的一致性与可重复性较好,是一种精确可靠的测量ACD与LT的工具.