目的 应用老年综合评估技术(CGA)筛查高龄人群中肌少症的发病情况及其危险因素.方法 选取在江阴市人民医院医疗集团就诊的718例老年患者,根据年龄分为非高龄组(<80岁,288例)和高龄组(≥80岁,430例),观察2组人群的肌少症发病率.将高龄组患者进一步分为非肌少症组(222例)和肌少症组(208例),采用CGA进行全面评估,从一般情况、实验室检测指标、老年共病和老年综合征等方面比较2组的差异,采用二元Logistic回归分析高龄人群肌少症的影响因素.结果 高龄组患者肌少症的患病率(48.3％)明显高于非高龄组(30.9％),差异有统计学意义(P<0.05);肌少症组与非肌少症组的年龄、婚姻状况、吸烟史、体质量指数(BMI)、共病指数、服用药物数量、日常生活能力、社会参与功能、衰弱、听力障碍、视力障碍、认知功能障碍、睡眠障碍、抑郁、营养风险、便秘、低密度脂蛋白、总胆固醇、空腹血糖和尿酸的差异有统计学意义(P<0.05).二元Logistic回归分析显示,婚姻状况、吸烟史、BMI、总胆固醇、共病指数、衰弱、听力障碍、认知功能障碍和抑郁是高龄肌少症的影响因素(P<0.05).结论 高龄人群肌少症发病率高,CGA可以全方位地筛查高龄肌少症的影响因素,为制定个体化的高龄肌少症管理方案提供可靠依据.

目的:分析高龄人群(≥75岁)发生动脉粥样硬化性心血管疾病(ASCVD)事件的危险因素,为指导全科医生对社区中有ASCVD患病高风险的高龄人群进行早期干预提供理论依据.方法:选取2018年1月至2021年3月期间在江阴市城南、城中以及华士社区卫生服务中心门诊就诊的高龄人群作为研究对象,共入选319例.采用二元Logistic逐步回归分析探究社区高龄人群的ASCVD风险的影响因素.结果:对照组98例,病例组221例,病例组中年龄、婚姻状况、睡眠质量情况、体力活动情况、失能情况、是否痴呆、颈动脉超声评分、血压控制水平、家族史、合并高血压、收缩压、总胆固醇、共病指数、服用药物数量与对照组比较差异有统计学意义(P<0.05).病例组中性别、吸烟史、饮酒史、合并糖尿病、体重指数、舒张压、高密度脂蛋白、低密度脂蛋白、甘油三酯、空腹血糖、糖化血红蛋白、尿酸、肌酐、尿素氮与对照组比较差异无统计学意义(P>0.05).经Logistic回归分析结果显示,血压控制水平、颈动脉超声评分、共病指数、服用药物数量是社区高龄人群ASCVD风险的影响因素(P<0.05).结论:血压控制水平、共病指数、服用药物数量是高龄人群ASCVD发病的影响因素,也是相对可控因素,社区全科医生应加强对血压控制不达标、合并多种疾病、服用药物多的高龄人群进行ASCVD风险评估.

目的:观察肠内营养中添加益生菌对高龄老年患者营养状态及血脂的影响.方法:本研究为随机、单盲,选择≥80岁的高龄全肠内营养者为受试者,随机分为对照组(肠内营养)和干预组(益生菌+肠内营养).分别测定试验开始时、1个月、2个月、3个月的血常规[白细胞(white blood cell,WBC)、血红蛋白(hemoglobin,Hb)、淋巴细胞绝对值(lymphocyte,L)、淋巴细胞百分比(lymphocyte％,L％)],营养相关检测[总蛋白(total protein,TP)、白蛋白(albumin,ALB)、前白蛋白(pro-albumin,pro-ALB)],脂质代谢血液学检测[三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)],并观察患者相关临床事件的发生,包括消化道反应、大便性状、发热、抗生素使用情况等.结果:(1)治疗3个月后,两组WBC、Hb、L、L％差异均无统计学意义(均P＞0.05).两组血清TP、ALB、pro-ALB差异均有统计学意义(均P＜0.05),干预组随着时间的越长,TP、ALB、pro-ALB增长越多(P＜0.05).(2)两组脂质代谢相关指标差异无统计学意义(P＞0.05).(3)两组间相关临床事件差异均无统计学意义(均P＞0.05).结论:联合益生菌的肠内营养方式可促进肠内营养的实施及支持效果,改善患者的营养状态.

背景在老年人群中开展动脉硬化检测可以早期评估心脑血管疾病风险及监测临床疗效.血清转化生长因子β1 (TGF-β1)及结缔组织生长因子(CTGF)已被证实为组织纤维化的关键因子,但其与老年人群血管硬化的相关性研究甚少.目的分析老年动脉硬化患者与TGF-β1、CTGF之间的关系,探讨TGF-β1、CTGF联合臂踝脉搏波传导速度(BaPWV)及颈动脉超声作为老年人群动脉血管病变评估和临床疗效监测指标的可行性.方法 选取2017年9月-2018年9月在江阴市人民医院老年医学科及心血管内科就诊的134例老年患者,将BaPWV高出标准值20％或颈动脉超声诊断有粥样硬化斑块者纳入动脉硬化组,其余纳入对照组.其中动脉硬化组69例,对照组65例.比较两组体质指数、血压、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿素氮(BUN)、血肌酐(Scr)、糖化血红蛋白(HbA1c)水平.采用酶联免疫吸附试验(ELISA)检测血清TGF-β1、CTGF水平.并比较两组高血压、糖尿病、脑血管疾病及冠心病发病率情况.结果 动脉硬化组收缩压(SBP)、平均动脉压(MAP)、HbA1c、BaPWV均高于对照组(P＜0.05).动脉硬化组和对照组TGF-β1水平比较,差异无统计学意义(Z=-1.499,P=0.134);动脉硬化组CTGF水平高于对照组(Z=-3.250,P=0.001).两组冠心病发病率比较,差异无统计学意义(P＞0.05);动脉硬化组高血压、糖尿病、脑血管疾病发病率均高于对照组(P＜0.05).结论 老年动脉硬化患者血清CTGF水平明显升高,可利用CTGF联合BaPWV及颈动脉超声作为老年人群动脉血管病变评估和临床疗效监测的指标.

目的 观察血脂康对老年动脉硬化患者血清结缔组织生长因子(CTGF)和转化生长因子β1(T G F-β1)水平的影响.方法 老年动脉硬化受试者144例,其中具有使用他汀类药物指征的受试者纳入观察组(84例),其余受试者纳入对照组(60例).两组均采用基础治疗;观察组在此基础上加用血脂康胶囊0.3～0.6 g,每天2次,治疗12个月.比较两组治疗前后HbA1c、血脂、BUN、SCr、CTGF、TGF-β1的变化.结果 观察组治疗后TC、LDL-C较治疗前降低(P<0.05),且低于对照组(P<0.05).治疗前观察组CTGF水平高于对照组(P<0.05),治疗后观察组CTGF水平低于治疗前(P<0.05).两组治疗前后TGF-β1水平无统计学差异(P>0.05).结论 血脂康有助于降低老年动脉硬化患者血清CTGF水平.

Objective To analyze the damage of corticospinal tract in ischemic stroke patients with diffusion tensor tractography (DTT).Methods Thirty-seven ischemic stroke patients who underwent routine MRI scanning and DTT within 3 days after their disease onset.Their bilateral corticospinal tracts were plotted using MRI software.The patients were divided into grade Ⅰ group (n=10),grade Ⅱ group (n=12),and grade Ⅲ group (n=15) according to the severity of their corticospinal tract damage.Their general clinical data and NIHSS score were recrded.The patients were followed up for 6 months,during which the recovery of their motor function was assessed according to the Fugl-Meyer score (FMS) and the risk factors for FMS were analyzed.Results The NIHSS score on admission was significantly higher in grade Ⅲ group than in grade Ⅰ group and grade Ⅱ group (P＜0.05).The recovery of motor function was significantly better and the NIHSS score was significant higher in grade Ⅰ group than in grade Ⅲ group.The FMS was significantly higher in grade Ⅰ,Ⅱ andⅢ groups after 6 months of treatment than on admission (P＜0.01).Multivariate linear regression analysis showed that corticospinal tract damage,white matter lesion and NIHSS score on admission were the independent risk factors for the recovery of motor function(P＜0.01).Conclusion DTT can assess the damage of corticospinal tract in ischemic stroke patients.The damage of corticospinal tract is an important risk factor for the recovery of motor function in ischemic stroke patients.

目的 探讨蒙特利尔认知评估量表(MoCA)在老年轻度认知功能障碍(MCI)患者筛查中的应用.方法 选择老年MCI患者56例为MCI组和认知功能正常者50例为对照组,分别给予MoCA、简易精神状态检查量表(MMSE)评估,并分析评估结果.结果 MCI组和对照组MoCA总分明显低于MMSE总分(P＜0.01).MoCA筛查MCI的敏感性为96.4％、特异性为84％;MMSE筛查MCI的敏感性为35.7％、特异性为100％.MoCA中除定向力项外,总分及其余各亚项的评分在MCI组和对照组间差异均有统计学意义(P＜0.01).结论 MoCA为高敏感性的MCI筛查工具,能全面评估MCI患者的认知功能,筛查MCI的敏感性优于MMSE.

Objective To study the application of ABCD3-I score in predicting the risk of early is-chemic stoke after transient ischemic attack (TIA) .Methods One hundred and eighty-two carotid TIA patients were divided into low risk group (n=40) ,moderate risk group (n=74)and high risk group (n=68) according to their ABCD2 ,ABCD3 and ABCD3-I scores .The incidence of ischemic stroke was observed within 7 days after TIA .Results The area under the ROC curve for ischemic stroke within 7 days after TIA was 0 .625 ,0 .713 and 0 .831 ,respectively .Twenty-seven patients (14 .8% ) developed ischemic stroke within 7 days after TIA .The incidence of ischemic stroke was significantly higher in moderate and high risk groups than in low risk group and in high risk group than in moderate risk group (6 .8% vs 0% ,32 .4% vs 0% ,32 .4% vs 6 .8% ,P< 0 .01) .The ABCD3-I socre was positively related with the incidence of ischemic stroke within 7 days after TIA (r=0 .486 ,P<0 .01) ,suggesting that ABCD3-I socre could significantly affect the incidence of ischemic stroke within 7 days after TIA (P<0 .05) .Conclusion ABCD3-I score can effectively predict the risk of early ischemic stroke after TIA ,and can thus be used in assessment and treat-ment of T IA .

目的：探讨 D-二聚体、降钙素原水平评估老年社区获得性肺炎（ CAP）患者预后的临床价值。方法选择老年 CAP患者共156例，入院时按肺炎严重度指数（ PSI）分为：PSI Ⅲ级组51例、PSIⅣ级组71例、PSIⅤ级组26例，比较各组 D-二聚体、降钙素原水平及住院时间及病死率。结果 D -二聚体、降钙素原水平 PSI Ⅲ级组＜PSIⅣ及组＜PSⅣ级组，各组间比较均有显著性差异。D -二聚体与 PSI 评分显著相关（r ＝0.63，P ＝0.000）；降钙素原与PSI评分显著相关（r＝0.435，P＝0.006）；住院时间与 PSI 评分相关（r ＝0.325，P ＝0.024）。结论入院时 D -二聚体、降钙素原水平能估测老年 CAP患者的病情严重程度及预计住院时间。

Objective To investigate the influnce factors of new diagnosed abnormal glucose metabolism in patients with acute cerebral ischemic stroke .Methods One hundres and twenty stroke patients without history of diabetes were divide into large artery atherosclerotic stroke (LAA), small arterial occlusive stroke(SAO), cardiac embolic stroke(CES), undeterminined etiology stroke (UND) subgroups according to the Trial of ORG 10172 in Acute Stroke Treatment(TOAST) classfication.The patients were tested oral glucose tolerance test (OGTT) one week later after stroke. The impaired glucose regulation ( IGR ) and diabetes patients called the abnormal glucose metabolism group ,compare related indicators and make multivariate Logistic regression analysis .Results There were 68 patients(56.7%) with normal metabolism, 52 patients (43.3%) with abnormal glucose metabolism.Among them, 38 cases were IGR (31.7%), 14 cases were diabetes (11.7%).The rate of abnormality of impaired glucose metabolism in LAA subgroup(63.8%) was significantly higher than the other subgroups (27.3%-31.4%)(all P<0.05).There was no statistically significant difference between the other subgroups .Compared with normal glucose metabolism group, age, the rate of hyperlipidemian and family history of diabetes were significant higher in abnormal glucose metabolism group (P<0.05 -0.01).Multivariate logistic regression analysis showed that hyperlipidemia ( OR=1.671,95%CI:1.208 -2.311,P=0.012), family history of diabetes (OR =1.421,95%CI:1.114 -1.813,P=0.042) and LAA(OR=2.825,95%CI:1.706-4.674,P=0.023) were independent risk factors of new diagnosed abnormal glucose metabolism in ischemic stroke .Conclusion There is a high prevalence of new diagnosed abnormal glucose metabolism in ischemic stroke .Hyperlipidemia , family history of diabetes and LAA are independent risk factors of it .

慢性阻塞性肺疾病(COPD)是一种不完全可逆的以气流受限为特征的疾病,气流受限呈进行性发展,在老年人中常见且多发[1].COPD患者存在的肺功能障碍可严重地损害患者的生活质量,是导致慢性阻塞性肺疾病急性发作期(AECOPD)反复发生的重要原因.实施呼吸康复策略,提高老年COPD患者呼吸肌的肌力和耐力,改善肺功能,可降低COPD患者的致残率和急性发作,对改善生活质量有着重要的意义.目前国内外在COPD康复方面有不少方法,其中不少需使用各种器械,严重影响了COPD在社区中的大规模推广和应用,我们采用一套简便易行的锻炼方法,即组合各种常见的简易式呼吸康复方法应用于稳定期老年COPD患者,取得较好效果,现报道如下.

目的探讨急性脑梗死患者脑微栓子与颈动脉粥样硬化斑块的关系。方法 82例急性脑梗死患者依据颈动脉超声检测分为颈动脉无斑块组和颈动脉斑块组,后者再分为不稳定斑块亚组和稳定斑块亚组。对所有患者应用经颅多普勒仪进行脑动脉微栓子监测。结果颈动脉斑块组微栓子阳性率(45.0%)高于无斑块组(18.2%),两者比较差异有统计学意义(P<0.05);颈动脉不稳定斑块亚组微栓子阳性率(67.9%)显著高于稳定斑块亚组(25.0%),两者比较差异有统计学意义(P<0.01)。结论颈动脉斑块的存在及不稳定性是导致脑动脉系统微栓子的重要因素之一,稳定颈动脉斑块是防治动脉至动脉栓塞的重要措施。

Objective To investigate the value of tumor type M2 pyruvate kinase (M2-PK) in the differential diagnosis of pleural effusion.Methods A total of 146 patients with pleural effusion during January 2006 to December 2008 were recruited at the department of respiratory medicine of the Shantou Affiliated Hospital and the First Affiliated Hospital of Sun Yat-sen Medical College.Pleural effusion was malignant in 72 cases (52 cases with lung cancer and 20 cases with metastatic lung cancer) and benign in 74 cases (54 cases with infective pleural effusion and 20 with transudation effusion).The patients were divided into a malignant pleural effusion group,an infective pleural effusion group,and a transudation group.Then the infective group was further divided into subgroups of tuberculosis pleural effusion group and parapneumonic effusion group.The concentration of tumor M2-PK in pleural fluid obtained during the first thoracocentesis was measured by enzyme-linked immunosorbent assay(ELISA).Results The concentration of tumor M2-PK was significantly higher in the malignant pleural effusion group compared with the benign pleural effusion groups(P<0.01).Significant differences were also found in the concentration of tumor M2-PK between malignant pleural effusion caused by lung cancer and metastatic lung cancer(P<0.05).When the cutoff value of tumor M2-PK was set at 18.68 U/mL,the sensitivity,specificity,and accuracy for the diagnosis of malignant pleural effusion was 87.6%,86.0%,and 87.4%,respectively.Furthermore,the detection of tumor M2-PK in combination with CEA showed better diagnostic sensitivity(96.0%),specificity (85.0%),and accuracy (91.1%).Conclusions The detection of tumor M2-PK in pleural effusion is of some clinical significance in the differential diagnosis of benign and malignant pleural effusion.The detection of tumor M2-PK in combination with CEA is a good diagnostic tool with high sensitivity and specificity.

目的应用实时三维超声心动图(RT-3DE)评价原发性高血压不同左心室构型患者右室功能的变化。方法选择正常对照组30例,原发性高血压患者113例,按照Ganau分型法,即根据左室质量指数(LVMI)和相对室壁厚度(RWT)将其分为4组:左心室正常构型组(LN组)、向心性重构组(CR组)、向心性肥厚组(CH组)、离心性肥厚组(EH组);分别进行RT-3DE检查,测量右室舒张末容积(RVEDV)、右室收缩末容积(RVESV)、右室每搏量(RVESV)及右室射血分数(RVEF)。结果对照组与高血压各组间性别构成、年龄、心率、体质量指数比较无显著性差异(P均>0.05);对照组与LN组间LVMI比较无显著性差异,但CR、CH、EH组与对照组、LN组相比其LVMI增大(P均<0.05);对照组、LN组、CR组间RVEDV、RVESV、RVSV、RVEF比较无显著性差异(P均>0.05);CH组、EH组与对照组、LN组、CR组的RVEDV、RVESV、RVEF比较均有显著性差异(P均<0.05),CH组RVSV与对照组、LN组比较无显著性差异,EH组与其他各组RVSV比较均有显著性差异(P均<0.05)。结论高血压患者不同左心室构型患者的右室功能存在不同程度差异,RT-3DE能简便、快速、准确、无创地确定该差异,为临床评估高血压不同左心室构型患者的右心功能提供了有力手段。

Objective To investigate the relationship between cerebral microbleeds(CMBs) and plasma IL-6 in patients with acute ischemic stroke(AIS).Methods On the basis of SWI,160 AIS patients were classified into groups of CMBs(59 cases,with CMBs) and NCMBs(101 cases,without CMBs).Plasma IL-6 was detected and compared between two groups.Results The incidence of CMBs was different among different stroke subtypes,in which small artery occlusion stroke was the highest.Plasma IL-6 was(10.08±1.79) pg/ml in group CMBs,which was higher than(8.97±1.39) pg/ml in group NCMBs(P<0.01).The severity of CMBs was positively correlated with plasma IL-6(r=0.682,P<0.001).Conclusion Plasma level IL-6 is closely correlated with CMBs.Inflammation may be involved in the development of CMBs in stroke patients.

目的 探讨ABCD2评分结合磁共振弥散加权成像(DWI)对短暂性脑缺血发作(TIA)后7d内发生脑梗死的风险预测价值.方法 以2010年3月至2012年3月住院的203例首次TIA患者作为研究对象,收集其临床资料和DWI检查结果,按照ABCD2评分法进行评分.分析不同ABCD2评分、DWI表现与TIA后7d内脑梗死发生率的关系.结果 203例TIA患者7d内脑梗死的发生率为12.8％.ABCD2评分与TIA后7d内脑梗死发生率呈正相关,ABCD2评分越高,脑梗死的发生率越高(r =0.786,P＜0.05)；低危(0～3分)、中危(4～5分)和高危(6～7分)患者间脑梗死发生率的比较差异有统计学意义(P＜0.05).DWI阳性的患者7d内脑梗死的发生率与DWI阴性比较差异有统计学意义(P＜0.01).ABCD2评分结合DWI预测模型的ROC曲线下面积(0.741)高于ABCD2评分法(0.665),差异有统计学意义(P＜0.01).结论 ABCD2评分法能有效预测TIA患者7d内发生脑梗死的风险,进一步结合DWI检查能提高预测的准确性.

目的观察阿仑膦酸钠治疗老年骨质疏松症(0P)的腰椎骨密度(BMD)变化。结果选择40例老年患者,采用意大利L`ACN集团生产的宇航员型双能X线骨密度仪进行BMD测定。随机分成治疗组服用阿伦磷酸钠70mg,每周一次,联合用钙尔奇D600mg,1次/d;对照组单用钙尔奇D600mg,1次/d,观察12月。每6月复查骨密度。以腰椎BMD为比较指标。结果治疗组在治疗后6月及12月腰椎BMD增加分别为1.95%和2.80%,与治疗前比较有统计学差异(P<0.05和P<0.01)。对照组在治疗后6月和12月腰椎BMD增加分别为0.95%和1.05%,与治疗前无统计学差异。结论阿仑膦酸钠可显著提高老年骨质疏松症腰椎骨密度

[Objective]To evaluate the clinical efficacy of donepezil combined with atorvastatin for senile patients with vascular cognitive impairment(VCI).[Methods]69 senile patients who were diagnosed with VCI were randomly divided into the donepezil combined with atorvastatin group(the treatment group,35 cases) and the donepezil group(the control group,34 cases),both two groups received the routine medication.Before treatment,12th week and 24th week of treatment,patients of two groups were tested for the pulsatility index(PI) and resistance index(RI) of major intracranial artery by transcranial Doppler(TCD),the scores of mini-mental state examination(MMSE) and daily living scale(ADL) were evaluated,and the results were statistically analyzed.[Results]There were significant differences in MMSE scores of the treatment group and the control group between before treatment and 12th week of the treatment(P0.01,P0.05).The difference between two groups was not significant(P0.05).There were significant differences in MMSE scores of the treatment group and the control group between before treatment and 24th week of the treatment(P0.01,P0.05).The difference in MMSE scores between two groups was significant(P0.05).There were significant differences in ADL scores of the treatment group and the control group between before treatment and 12th week of the treatment(P0.05,P0.05).The difference in ADL scores between two groups was not significant(P0.05).There were significant differences in ADL scores of the treatment group and the control group between before treatment and 24th week of the treatment(P0.01,P0.05).The difference in ADL scores between two groups was significant(P0.01).At 12th week of treatment,there was no significant difference in cerebral artery PI values between the treatment group and the control group(P0.05,P0.05).At 24th week of treatment,there were significant differences in cerebral artery PI values between the treatment group and the control group,and the difference in PI values of the treatment group between the before treatment and 24th week of the treatment was significant(P0.05).At 12th week of treatment,there was no significant difference in cerebral artery RI values between the treatment group and the control group(P0.05).At 24th week of treatment,there were significant differences in cerebral artery RI values between the treatment group and the control group(P0.05),and the difference in RI values of the treatment group between the before treatment and 24th week of the treatment was significant(P0.05).[Conclusion]Donepezil can improve the cognitive function in patients with VCI.Donepezil combined with atorvastatin can further improve the cognitive function of VCI patients,and enhance patients' quality of life.

Objective: To evaluate the curative effect of left ventricular regional function of the patients with acute myocardial infarction with left heart insufficiency with Perindopril combined Metoprolol by real-time three-dimensional echocardiography(RT-3DE).Methods: 46 AMI patients with left heart insufficiency were divided into control group and treatment group randomly and followed up for six months,three-dimensional image data were acquired analyzed offline.Regional volume curves and regional ejection fraction curves were derived.Regional diastolic volumes,regional systolic volumes and regional ejection fractions were compared respectively between two groups.Control group received conventional AMI therapy,including Aspirin and(or) Clopidogrel,Statins,Nitrates,conventional doses of Metoprolol(25 mg,2 times a day),Perindopril(2-4 mg,1 time a day) and Trimetazidine,et al;the treatment group used of the target dose of Perindopril 8 mg/d,Metoprolol 200 mg/d or up to Maximum tolerated dose on the basis of control group.Results: The general information had no significant difference between the two groups before the treatment(P0.05);the RLVEF,REF of two groups had significant difference before and after treatment(P0.05,P0.01);the differences of REF between two groups after treatment was significantly statistical(P0.05);the adverse events between of groups had no significant difference(P0.05).Conclusion: The target dose of Perindopril combined Metoprolol are beneficial to the left ventricular remodeling of infracted segments in the patients with AMI with left heart insufficiency.

Objective To observe clinical effect of thoracentesis-tube drainage combined with cisplatin intracavitary administration on patients with ma1ignant pleural effusion and analyze the possible mechanism.Methods 79 patients with malignant pleural effusion were divided into administration group(39 cases),drainage group(27 cases) and control group(9 cases).The patients of administration group were thorac-injected with cisplatin after pleural effusions were drained.In the drainage group,patients were given thoracentesis drainage only,and in the control group,patients only received conventional chemotherapy.Results The effective rate in administration group(79.49%) was significantly higher than that of the drainage group(55.56%) and the control group(22.22%,P<0.01).Conclusion Thoracentesis-tube drainage combined with cisplatin intracavitary administration has remarkably effects on malignant pleural effusion,and has clinical significance for remission the patients' condition.