Objective:To establish and perfect TLC identification method of Yinhuang Lidan Granule so as to provide evidence for the quality control. Methods:Identify the Dahuang and Yin by thin-layer chromatography( TLC)method. Results:The characteristics of two medicinal materials spots were identified on TLC while no such blank spots in the control chromatography. Conclusion:This method is simple and sensitive with good reproducibility,which can be used to control the quality of Yinhuang Lidan Granule.

Objective:To establish and perfect quality control of Wuhei Shengfa Granule. Methods:Identify the Heshouwu and Danggui by the method of TLC. Results:The characteristics of two medicinal materials spots were identified on TLC while no such blank spots in the control chromatography. Conclusion:This method is simple and has good reproducibility,which can be used as indicators of the quality control of the preparation.

目的:了解我院门诊使用中成药的情况,分析其中存在的问题,促进临床合理使用中成药。方法:随机抽查我院2012年中成药处方,对中成药的使用情况进行统计分析。结果:抽查中成药处方7300张,不合格处方占总处方的34.1%。主要表现在辨证与用药不符、重复用药、联合用药不当、用法用量不当、使用疗程不当、配伍禁忌等几个方面。结论:应加强临床医生和药师的培训,提高中医药知识水平,规范合理地使用中成药。

目的:了解我院开展抗菌药临床应用专项整治工作的结果,以提高我院抗菌药合理使用水平。方法:随机抽取2010年和2011年住院病历各840份,Ⅰ类切口手术病历各200份,门诊处方各4000份;比较干预前后门诊处方、住院和Ⅰ类切口手术患者抗菌药使用情况、抗菌药ADR发生率、抗菌药使用费用等。结果:干预前后抗菌药使用率、不合理使用率、病原学送检率、Ⅰ类切口抗菌药使用率、品种选择合理率、疗程符合率等指标的差异均有统计学意义(P<0.01);门诊患者抗菌药DDDs干预前后分别为4565.03和2824.35;住院患者抗菌药使用强度干预前后分别为47.2和37.8。结论:经过抗菌药临床应用专项整治,我院临床不合理应用抗菌药的现象得到明显遏制,抗菌药治疗水平明显提高,说明干预措施有效可行。

OBJECTIVE: To analyze the use of antibiotics in the patients of our hospital to provide references for clinical rational use of antibiotics.METHODS: 4 216 outpatient prescriptions and 420 medical records in the first half year of 2011 were sampled randomly for statistical analysis of the antibiotic use.RESULTS: The rate of antibiotic use in outpatients was 34.1%(1 437/4 216);in the inpatients,the rate of antibiotic use was 70.0%(294/420),with the rate of rational drug use of 68.1%(286/420) and the rate of specimen test of 53.3%(224/420).The antibiotics ranked among the last 5 places in respect of DDC were sparfloxacin,erythromycin,gatifloxacin,clarithromycin and ampicillin/probenecid,with all administered orally.The top five antibiotics in terms of DDDs for inpatients were cefoperazone/sulbactam,cefalotin,mezlocillin,cephazolin and cefuroxime.The top 4 antibiotics ranked by DUI in descending order were ceftezole clindamycin mezlocillin levofloxacin1.The total antibiotic use density which stood at 53.3 DDD was significantly higher than the specified value of 40 DDD.CONCLUSION: The use of antibiotics in our hospital was basically rational yet far from perfect,thus it is urgent to tighten monitoring the use of antibiotics to promote clinical rational use antibiotics.

Objective: To analyze the use of antibiotics in the patients of Tianmen First People's Hospital before and after Special Administration of rational use of antimirobial agents in order to promote clinical rational drug use.Methods: A total of 1680 medical records and 100 records of type I incision operation(thyroid/mammary gland/hernia/closed fractures) were randomly selected from January 2010 to December 2011.Statistically analyze the antibiotic use rate,total antibiotic use density,rate of etiological examination,DDDs,and DUI before and after Special Administration.And the antibiotic use of type I incision operation were evaluated.Results: The use rate of antibiotics was 68.5% in inpatients,and total antibiotic use density was calculated as 49.8 DDD/100 patient days before Special Administration,and respectively 56.2% and 49.8DDD after,showing obvious drop(P0.05).Before Special Administration,the DUI of 4 kinds of antibacterials were slightly greater than 1.0,which were in the following order: cefoperazone/sulbactamcefalotin= cephazolincefuroxime.After Special Administration,the DUI of 2 kinds were slightly greater than 1.0,which were sulbenicillin cefoperazone/sulbactam.The use rate of antibiotics for patients of type I incision operation were also reduced,and tha accordance rate of treating courses and drug rational user rate were increased(P0.05).Conclusion: The use of antibiotics in our hospital basically met the requirement of Special Work Plan for Clinical Antibiotics Use,but more efforts should be made to make a progress,for example,to be more careful in choosing Type I incision operation,course of treatment and cure with medicine,to enhance monitoring the use of antibiotics in Type I incision operation.Only in these ways could clinical rational drug use be economically and effectively enhanced.

目的:建立参芍通脉片的制备及质量控制方法,并观察其治疗高血脂的临床疗效。方法:选择芍药苷为指标,建立HPLC法测定其含量。120例高脂血症患者随机分为两组,以辛伐他汀片为对照观察参芍通脉片的临床疗效。结果:芍药苷在1.66～11.59mg·L~(-1)范围内线性关系良好r=0.9999(n=7),平均回收率为100.04%,RSD为1.18%(n=9);参芍通脉片能显著降低高脂血症患者TC、TG、LDC-C及AI(P<0.01),升高HDL-C(P<0.05),调脂疗效与辛伐他汀基本相当(P>0.05)。且对肌酸激酶影响较小。结论:参芍通脉片质量控制方法简便可行,专属性强,准确可靠,用于高脂血症治疗安全有效。

Astragalus is the root of the Astragalus membranaceus plant,including Astragalus menabranaceus(Fish.) Bge.var.meongholicus(Bge.)Hsiao or Astragalus membranaceus(Fisch.) Bge.It has a sweet taste and warm properties,and possesses virtue of "Buqishengyang,Yiweigubiao,Tudushengji,Lishuituizhong".Pharmacological studies showed Astragalus contains multiple active con-stituents like glycoside,polysaccharide,chromocor,amino acid,etc.Many physiological functions of Astragalus have been reported such as enhancement of immunological function,protection of endocrine and cardiovascular system,etc.Many of its functions are related with anti-axidative and mitochondrial damage,and with calcium homeostasis disturbance.And Overload of calcium,injury of oxygen free radicals and mitochondrial damage are the common channels for activating programmed apoptosis.So we review the progress of the ef-fect of saponins,polysaccharide and flavonoids of Astralus on cell apoptosis in terms of the three aspects.

<药品不良反应报告和监测管理办法>对药品不良反应ADR进行监测和报告可以及时阻止已知的ADR继续发生、恶化,也有利于根据已知的ADR及时判断或预测新药的ADR,减少ADR对人类健康和生命造成不良影响,现对我院908例ADR进行回顾性分析,为临床合理用药提供参考.

目的:建立益肝颗粒的质量控制方法。方法:采用薄层色谱法对白芍、黄芪、当归进行定性鉴别,用HPLC法测定白芍中芍药苷的含量。结果:芍药苷含量在14.6~87.6mg.L-1范围内线性关系良好(r=0.999 8),平均回收率为100.3%,RSD为0.69%(n=5)。结论:制定的质量控制方法可以保证益肝颗粒的质量。