Objective:To investigate the muscular quality and its related influencing factors in elderly with sarcopenic obesity.Methods:The internalized 696 elderly subjects meeting inclusion and exclusion criteria were divided into four groups including the sarcopenic obesity(n=55), sarcopenia(n=8), simple obesity(n=481)and normal control(n=152)groups.The intergroup difference was retrospectively analyzed in the parameters of body composition, dietary intake of total energy and three major nutrients and their proportions.Multiple linear regression analysis was used to analyze the influencing factors related to the occurrence of sarcopenic obesity in the elderly.Results:The sarcopenic obesity group versus normal control group showed a higher level or value in age, body mass index, waist-hip ratio, fat mass, percentage of body fat, visceral fat area, fasting blood glucose, estimated glomerular filtration rate( P<0.01 or 0.05), and showed a lower level or value in grip strength, skeletal muscle, skeletal muscle index, muscle quality(grip strength/limb skeletal muscle), intake of energy, carbohydrate, fat and protein, body weight-adjusted intake of energy and protein, as well as ideal body weight-adjusted intake of energy and protein( P<0.01). The detection rate of sarcopenic obesity was 7.90%(n=55), including 7.60% in males(n=48)and 11.48% in females(n=7 cases). The detection rate of sarcopenic obesity was increased along with increasing age with 0.07%(2/287)in 60-69 years old group, 4.94%(12/243)in 70-79 years old group, and 24.70%(41/166)in ≥80 years old group( χ2=87.76, P<0.01). Taking the median point of grip strength/limb skeletal muscle volume as the cutoff point, the decrease rate of muscle quality was 12.36%(86/696)in total elderly subjects, 2.63%(4/152)in the control group, 11.64%(86/635)in the obesity group, 37.5%(3/8)in the sarcopenia group and 41.82%(23/55)in the sarcopenic obesity group, with an increasing trend of the decrease of muscle quality, which had significant differences( χ2=62.25, P<0.01). Multiple logistic regression analysis showed that aging, excessive visceral fat area, insufficient protein intake and decreased basal metabolism were the independent risk factors for sarcopenic obesity in elderly people( P<0.01 or P<0.05). Conclusions:The incidence of decrease of muscle quality is higher in the elderly with sarcopenic obesity than other elderly groups.Sarcopenic obesity is correlated with aging, insufficient intake of protein, decreased basal metabolism and excessive visceral fat accumulation.Individual evaluation and support is necessary in elderly people with sarcopenic obesity.

Objective:To analyze the prevalence of malnutrition in stable-phase elderly patients with chronic obstructive pulmonary disease (COPD) using the Global Leadership Initiative on Malnutrition (GLIM) criteria.Methods:Using cross-sectional survey, 60 elderly patients with COPD in stable phase were investigated, with 72 elderly patients without COPD in the same age group selected as controls. Differences in basic characteristics, anthropometric indicators, hematology indicators and body composition were compared between the two groups. According to the GLIM diagnostic criteria for malnutrition, the first step is nutritional risk screening, the second step is to diagnose malnutrition, and the third step is to determine severe malnutrition. The prevalence of malnutrition and severe malnutrition were investigated.Results:The levels of total protein, albumin, creatinine, and lymphocyte percentage in the elderly stable COPD group were significantly lower than those in the control group. The nutritional risk and the prevalence of malnutrition in elderly COPD patients were significantly higher than those in the control group, and the prevalence of severe malnutrition was higher .Conclusions:Elderly stable COPD patients of different age groups have a higher nutritional risk. The onset age of malnutrition is younger than that of non-COPD patients and early intervention is required.

Objective:To analyze influencing factors for sarcopenia in people of advanced age, in order to provide insight and evidence for the prevention and treatment of sarcopenia in people belonging to this age group.Methods:Data from 167 people of advanced age seeking care at our department from December 2014 to July 2017 were retrospectively analyzed.According to the diagnostic criteria for sarcopenia of the Asian Working Group for Sarcopenia, subjects were divided into the sarcopenia group( n=46, 27.5%)and the non-sarcopenia group( n=121). Differences in body composition, energy intake, quantities and proportions of three major nutrients were analyzed between males and females.Related influencing factors for sarcopenia were analyzed by using multiple linear regression. Results:Compared with the non-sarcopenia group, the sarcopenia group had lower body mass index, waist-hip ratio, fat mass, total energy intake and protein( P<0.05)but higher age and fat intake( P<0.05). Values for grip strength, muscle mass, index of skeletal muscle, adjusted muscle mass by body mass index, total energy intake, carbohydrates, fat and protein were lower and the percentage of body fat was higher in females than in males( P<0.05). Multiple Logistic regression analysis showed that insufficient intake of protein( β=-0.290, OR=0.748, 95% CI: 0.569-0.984, P<0.05), reduction of body fat mass( β=-2.673, OR=0.069, 95% CI: 0.010-0.488, P<0.05)and excessive visceral fat accumulation( β=0.739, OR=2.094, 95% CI: 1.219-3.597, P<0.01)were correlated with sarcopenia in people of advanced age. Conclusions:The occurrence of sarcopenia is higher in people of advanced age and is related to insufficient intake of protein, reduction of body fat mass and excessive visceral fat accumulation.Individualized nutrition evaluation and support should be carried out as early as possible for people in this age group.

目的 比较老年肌少症性肥胖不同诊断方法的检出率,并分析诊断标准间的一致性.方法 回顾分析2014年12月至2017年7月北京医院营养科696例老年人临床资料,根据"2019亚洲肌少症诊断和治疗共识",将696例老年人分为肌肉减少症组(63例)和非肌肉减少症组(633例).分别采用世界卫生组织(World Health Organization,WHO)法,60％体脂率法和体重指数(body mass index,BMI)法的肥胖诊断标准,对比三种方法对老年肌少症性肥胖检出率和诊断一致性.结果 肌肉减少症组BMI、握力、骨骼肌质量及血液白蛋白、甘油三酯和血红蛋白水平低于非肌肉减少症组(P<0.05),而年龄、体脂百分率、合并冠心病率高于非肌肉减少症组(P<0.05).WHO法、60％体脂率法和BMI法对老年肌少症性肥胖症的检出率分别为7.90％、6.75％、0.86％,其中60％体脂率法与WHO法诊断一致性较好(Kappa=0.853,P<0.01);BMI法与WHO法诊断一致性较差(Kappa=0.059,P<0.01),BMI法的检出率明显低于另两种方法(P<0.01).结论 WHO法对老年肌少症性肥胖的检出率最高;60％体脂率法与WHO法的诊断一致性较好;BMI法检出率最低,不能有效检出老年肌少症性肥胖者.

Objective To analyze the dietary habits, energy intake and expenditure, anthropometrics, and body composition of the outpatients visiting the weight loss clinic of Beijing Hospital.Methods We pro-spectively enrolled 89 consecutive patients with body mass index ( BMI) ≥24 kg/m2 from November 2014 to August 2015 in the weight loss clinic of Beijing Hospital.There were 35 male and 54 female, with the mean age of (45.8 ±16.4) years.We divided them into two groups:the diabetes group (n=35) and the non-diabetes group (n=54), and compared the dietary habits, energy intake and expenditure, anthropometrics and body composition between the two groups.Results Regardless of diabetes, the overweight and obese patients all ate fast, mostly finishing a meal in about 10 minutes.They preferred Chinese food and meat, and disliked hot food.The frequency of dinning out in the non-diabetes group (3-5 times per week) was higher than that in the diabetes group (1-2 times per week) .Compared with the diabetes group, the non-diabetes group had higher fat-to-energy ratio [(34.9 ±7.6)%vs.(30.8 ±5.9)%], but lower carbohydrate intake [(232.2 ±59.7) g vs.(283.6 ±89.5) g], carbohydrate-to-energy ratio [ (47.9 ±8.3)%vs.(53.4 ±7.1)%], and the ratio of resting metabolic rate to body weight [ (66.9 ±9.6) kJ/(d? kg) vs.(71.1 ±7.9) kJ/(d? kg)] (all P<0.05).There were no statistically significant differences between the two groups in total energy intake, pro-tein intake, high quality protein intake, fat intake, protein-to-energy ratio, and resting metabolic rate (all P>0.05).Anthropometrics showed that the mean BMI of the patients was (32.8 ±4.4) kg/m2, with the maxi-mum being 53.5 kg/m2.The hip circumference [ (117.15 ±9.9) cm vs.(111.1 ±8.2) cm], upper arm circumference [ (36.4 ±3.8) cm vs.(34.0 ±3.3) cm], and triceps skinfold thickness [ (36.1 ±8.9) mm vs.(31.6 ±8.8) mm] were larger in the non-diabetes group than in the diabetes group (all P<0.05), but the mean age was lower in the non-diabetes group [ (41.7 ±16.9) years vs.(52.9 ±13.1) years) (P=0.01).There were no statistically significant differences between the two groups in body weight, BMI, waist circumference, neck circumference, and bilateral hand grip strength (all P>0.05).According to body compo-sition analysis, the body weight [ (94.8 ±18.3) kg vs.(86.9 ±17.2) kg], body fat mass [ (39.7 ± 11.3) kg vs.(33.5 ±8.9) kg], body fat percentage [ (41.7 ±6.5)%vs.(38.5 ±6.7)%], and visceral fat area [ (145.3 ±24.8) cm2 vs.(130.7 ±27.5) cm2 ] were larger in the non-diabetes group than in the di-abetes group ( all P<0.05) .There were no statistically significant differences between the two groups in BMI and skeletal muscle mass (both P>0.05).Conclusion Compared with diabetes patients, overweight and obese non-diabetes patients may be younger, having worse dietary habits, and having larger body fat mass, body fat percentage, and visceral fat area.

生活方式、膳食模式的改变,使我们的健康受到了更大的威胁.有调查研究显示,个人健康和寿命的60％取决于以行为生活方式为主的自身因素,70％的疾病和人们的行为生活方式有关. 世界卫生组织曾宣布维护健康的四大基石:平衡饮食、适量运动、戒烟限酒、心理健康.健康的饮食可以帮助预防所有形式的营养不良以及包括糖尿病、心脑血管疾病和癌症等非传染性疾病.

无论是专业的运动员,还是希望通过运动减重的人群,亦或是想通过运动塑形的爱美人士,在运动前、运动中、运动后都应进行营养支持.合理的营养支持是进行科学运动的物质基础.

Objective To evaluate the nutritional status and risk factors for sarcopenia in diabetes.Methods 297 diabetic patients who visited nutrition clinic of Beijing Hospital during the period from January 2013 to December 2014 were retrospectively analyzed.The patients were divided into overweight group (BMI ≥ 24.0 kg/m2) and non-overweight group (BMI ≤ 23.9 kg/m2), and the differences in anthropometry, body composition, laboratory indexes, dietary intake were analyzed between these two groups.The risk factors for sarcopenia in diabetes were analyzed by multiple linear regression.Results There were 183 patients in the overweight group and 114 in the non-overweight group.Compared with the overweight group, the left and right hand grip strength [(24.14 ± 7.76) kg vs.(27.78 ± 9.31) kg, P =0.00;(25.55 ± 7.86) kg vs.(28.62 ± 9.55) kg, P =0.01], waist-to-hip rate (0.85 ±0.06 vs.0.92 ± 0.07, P =0.00), arm muscle circumference [(21.45 ±3.73) cm vs.(25.18 ±4.36) cm, P =0.00], the muscle mass [(37.64 ±6.58) kgvs.(45.66±8.92) kg, P=0.00], percentage of body fat [(27.25 ±8.15)％ vs.(35.52 ± 6.56)％, P=0.00], visceral fat area [(71.56±25.28) cm2 vs.(118.84±28.18) cm2, P=0.00],and skeletal muscle index [(6.22 ± 1.17) kg/m2 vs.(7.41 ± 1.25) kg/m2, P =0.00] in the non-overweight group were significantly lower.Hemoglobin and serum glucose level were also significantly lower in the non-overweight group [(136.29 ± 14.81) g/L vs.(141.01 ± 13.47) g/L, P =0.03;(7.08 ± 2.28) mmol/L vs.(7.76 ±2.57) mmol/L, P =0.03].The total protein and albumin levels showed no significant inter-group differences (P =0.15, P =0.52), nor did the energy and protein intakes (P =0.17,P =0.35).The detection rate of sarcopenia was 10.4％ (31/297), which was higher in the non-overweight group than in the overweight group (22.8％ vs.2.7％, P =0.00).Female (B =-1.371, 95％ CI =-1.595--1.146), aging (B=-0.018, 95％ CI=-0.027--0.009), lower BMI (B=-0.115,95 ％ CI =0.092-0.138) , and less energy intake (B =0.014, 95 ％ CI =0.000--0.029) were the major risk factors for skeletal muscle index reduction.Conclusion Moderate overweight as measured by BMI indicates the better nutritional status in diabetes patients compared with non-overweight patients, which might be helpful for the prevention of sarcopenia.

Objective To explore the relationship between lipids profile and body composition in the young and middle?aged adults. Method The relationship between body composition and lipids profile was examined in 642 adults (21-60 years, 178 male, 464 female). According to the result of body composition assessment, they were assigned to three groups: Normal (N, n=272), Obesity (O, n=245), Sarcopenic Obesity (SO, n=125). The lipids profile among three groups and its related factors were analyzed. Results In groups N, O and SO, the levels of total cholesterol (TC), triglycerides (TG), low density lipoprotein?cholesterol (LDL?C) increased gradually (P<0.01), and the high density lipoprotein?cholesterol (HDL?C) level decreased gradually (P<0.01). In a multiple logistic regression analysis, the odds ratio for high levels of TC, TG, LDL?C and low level of HDL?C risk increased gradually in groups N, O and SO [compared to group N, the odds ratio of the four kinds of dyslipidemia in group O were 2.617 (1.117-6.132), 3.549 (1.481-8.503), 4.618 (1.288-16.564), 1.222 (0.529-2.822), respectively, and in group SO were 5.915 (2.512-13.926), 10.430 (4.400-24.722), 9.522 (2.637-34.388) , 4.253 (1.957-9.242) , respectively]. After adjusting for age, sex, waist?to?hip ratio and visceral fat area, the odds ratio for high level of TG risk still increased gradually in group N, O and SO [compared to group N, the odds ratio of group O was 3.565 (1.319-9.632), and of group SO was 8.173 (2.685-24.881)]. Moreover, the odds ratio for high TC and low HDL?C levels of group SO were higher than those of group N [compared to group N, the odds ratio in group SO were 5.658 (1.871-17.111), 6.823 (2.119-21.969) respectively]. With stepwise multivariate logistic regression analysis, for male, the related factors for high levels of TC, TG and low level of HDL?C were high percentage of body fat;sarcopenia, sarcopenia obesity;sarcopenia, respectively. For female, the related factors for high levels of TC, TG and LDL?C were sarcopenia, aging;high percrntage of body fat, aging;sarcopenia, aging, respectively. Conclusion SO was the main risk factor for dyslipidemia in young and middle?aged adults, even more severe than obesity alone and sarcopenia was the risk factor of high TG, low HDL?C levels for male;and the risk factor of high TC, high LDL?C levels for female.

很多孕妇在产检时,有一项检查是糖筛,具体就是检查前要空腹12小时,然后将葡萄糖粉50克溶于200ml水中,5分钟内喝完喝,隔一小时后测血糖,看数值有没有超标.这项检查是为了尽早检测出孕妇是否有妊娠糖尿病.那什么是妊娠糖尿病呢? 什么是妊娠糖尿病?有什么特点? 妊娠期糖尿病(gestational diabetes mellitus,GDM)是妊娠期最常见的合并症之一,是指妊娠后首次发生或发现的不同程度糖尿病或糖耐量异常.随着饮食结构的改变,劳动强度的降低,高龄产妇的增多,我国妊娠糖尿病的发病率呈逐年增高的趋势.

目的 比较应用血清白蛋白、改良SGA法(MQSGA)和MIS评分预测腹膜透析(PD)患者住院风险的差异.方法 横断面及回顾性研究.选择符合纳入标准的57例病情稳定的腹膜透析患者,对其进行改良SGA和MIS评分,以及血清白蛋白等各项临床指标检测,记录患者1年内住院情况,分析不同评估方法对患者营养状态的判定及其与住院风险相关性的差异. 结果 ①3种营养评估方法对腹膜透析患者诊断营养不良的发生率由低到高分别为:血清白蛋白(57.9％);MQSGA评分(70.2％);MIS评分(100％).②3种营养评估方法之间的相关性显著(P＜0.01);MQSGA和MIS评分与住院频次和各项临床营养指标的相关性显著(P＜0.01).③以PEW为标准,血清ALB、MQSGA和MIS评分对营养不良诊断的ROC曲线下面积分别为0.028、0.966、0.961.④住院组患者的血清白蛋白、前白蛋白水平低于非住院组(P＜0.05),住院组患者的Hs-CRP水平以及MQSGA和MIS评分均显著高于非住院组(P=0.000).⑤非条件Lo-gistic多元回归分析显示MQSGA与腹膜透析患者住院的相对危险度最高[RR=2.559,95％ CI (1.498～4.372),P=0.001].结论 MIS评分诊断腹膜透析患者营养不良的发生率最高,MQSGA与MIS评分具有相似的营养评估效果,MQSGA与MIS评分都具有预测腹膜透析患者住院风险的价值,MQSGA对住院风险的预测价值相对更高.

Objective To investigate the relationship between dietary intake and body composition in elderly type 2 diabetes (T2DM). Methods Retrospectively analyzing the differences of body composition between age(older group:≥60 years and younger group:<60 years),and further analyzing the differences between genders and overweight or not in older group. The related dietary factors of physical makeup in the elderly patients were investigated with multiple linear regression analysis,included the intake of energy and macronutrients. Results Compared with younger group,older group had lower body mass index,grip strength,and muscle mass,and hemoglobin,albumin,fasting blood glucose levels(t=-3.309 to-1.983,all P<0.05). There was no significant differences in waist-hip ratio,percentage of body fat, visceral fat area and the intake of total energy,quantity and proportion of macronutrients between the age groups(t=-1.435 to 0.316,all P>0.05). In elderly group,female had higher percentage of body fat,and lower grip strength,muscle mass(t=-3.911,-2.207,-2.825,13.921,all P<0.05). However,the adjusted energy intake by body weight was lower in non-overweight patients in older group(t=3.239,P<0.05). The detection rates of sarcopenia and muscle mass reducing were 6.3%and 34.0%in older group,respectively. Multiple linear regression analysis showed that insufficient intake of energy(B=-1.4000,P=0.045,95%CI:-2.770 to-0.029),protein(B=-0.0095,P=0.013,95%CI:-0.168 to-0.021),and excessive visceral fat accumulation(B=0.019,P=0.007,95%CI:0.006 to 0.033)were the independent risk factors of muscle mass reducing in elderly T2DM patients. Conclusions The decrease of muscle mass in elderly diabetic patients relates to insufficient intake of energy and protein,and excessive visceral fat accumulation. Individual nutrition evaluation and support is necessary especially in elderly diabetic patients.

目的:探讨持续性腹膜透析(Continuous ambulatory peritoneal dialysis,CAPD)患者蛋白质摄入情况与其营养状况及炎症水平的相关性.方法:CAPD患者31例,规律透析4～70个月,采用三日饮食记录法记录患者饮食情况,计算患者每日蛋白质、脂肪、碳水化合物及能量摄入水平,根据患者蛋白质摄入情况将其分为低、中、高3组[DPI分别为＜0.8g/(kg·d)、0.8～1.2g/(kg·d)、＞1.2g/(kg·d)].测定3组患者血红蛋白(HGB)、总蛋白(TP)、白蛋白(ALB)、前白蛋白(PA)、超敏C反应蛋白(hs-CRP)水平,比较3组间各项指标的差异.结果:3组间比较,DPI低等组和DPI中等组,HGB水平高于DPI高等组,差异具有统计学意义(P值分别为0.42和0.32);DPI中等组TP、ALB、PA的水平高于其他2组,其中DPI中等组与DPI高等组之间的差异具有统计学意义(P=0.28).DIP中等组,hs-CRP水平低于其他两组,其中DPI中等组和DPI高等组之间的差异具有统计学意义(P=0.23).结论:腹膜透析患者蛋白质的摄入水平与其营养状态及体内的炎症水平密切相关.摄入适量的蛋白质[DPI =0.8～1.2g/(kg·d)]有利于其营养状态及炎症水平的控制.DPI过低,患者营养不良的发生风险也会增高.DPI过高,患者的透析充分性较差,体内氮质血症较严重,影响其营养状态,其体内的炎症水平也会增加.

Objective To explore the factors relating to serum lutein level in elderly patients with early age-related macular degeneration (AMD).Methods 102 early AMD patients diagnosed by international diagnostic criteria were selected.The level of serum lutein was measured by HPLC,and dietary intake was estimated by food-frequency questionnaire (FFQ).The factors relating to serum lutein level were analyzed by Pearson correlation and multiple regression analysis models.Results Serum lutein level was higher in female AMD patients than in male AMD patients [(0.33±0.31) μmol/L vs.(0.21 ±0.19) μmol/L,t=2.21,P＜0.05].Serum lutein level was positively correlated with dietary lutein (r=0.49,P＜ 0.001),but not correlated with age,BMI,and other nutrient intake after adjustment for caloric intake.Dietary lutein was mainly from corn,spinach,leeks,eggs,chrysanthemum,pumpkin,broccoli,lettuce,asparagus and peas.Intakes of spinach,pumpkin,asparagus were significantly associated with serum lutein level.Conclusions Elderly patients with AMD should increase the intakes of lutein-rich vegetables to increase the serum lutein level.

Objective To investigate the prevalence of malnutrition,nutritional risk and application of nutritional support in hospitalized patients in medical wards.Methods 398 adult patients in medical wards of Beijing Hospital from April to June in 2011 were consecutively enrolled.The patients were screened using Nutritional Risk screening 2002(NRS2002) on admission NRS2002 score≥3 was classified as nutritional risk of BMI18.5 kg/m2 with impaired general condition was defined as malnutrition.The nutritional support application during hospital stay was recorded.Results The prevalence of malnutrition was 14.1% and the nutritional risk was 33.7% in all 398 patients.The prevalences of malnutrition in Gastroenterology and Oncology wards were significantly higher than that in Immunity ward.The prevalence of nutritional risk in Oncology,Gastroenterology and Neurology wards were significantly higher than in Endocrinology and Immunology wards.70.9%(95/134) patients with NRS2002≥3 received nutritional support,and 13.6%(36/264) patients with NRS20023 received nutritional support.96.4%(54/56) patients with malnutrition received nutritional support,and 22.5%(77/342) patients with no-malnutrition received nutritional support.The average PN:EN ratio was 3∶ 1.Conclusions The prevalence of malnutrition and nutritional risk is high in Gastroenterology,Oncology and Neurology wards.More attention should be payed on the enteral nutrition,which may be performed first in the malnutrition or nutritional risk inpatients.

【Objective 】To investigate the relationship between early atherosclerosis and dietary nutrients intake.【Method】A total of 200 subjects 45—65 years old were recruited from a community in Beijing.Common carotid intima-media thickness was measured by carotid ultrasonography,and all subjects were asked to complete 24h recall dietary survey.【Result 】The intake of energy,protein,fat,and carbohydrate in atherosclerosis cases was higher than that in control group,however,there was no significant difference between the groups.The energy ratio of 3 yielding nutrients in 2 groups were 20.7%,22.4%,54.8% and 21.3%,22.9%,53.1%,respectiiely.In Logistic Regression Model,thiamine was positively correlated with early atherosclerosis,while the intake of K was negatively correlated.【Conclusion】 Risk factor and protective factor in dietary were simultaneously in the community population,and healthy dietary and balance nutrition should be advocated to prevent early atherosclerosis related cardiovascular diseases.

Objective To observe the effects of different interventions on the body mass index (BMI) and body fat content in overweight and obese adolescents, with an attempt to design reasonable weight relief program.Methods Totally 67 overweight or obese adolescents from a middle school of Beijing were randomly divided into three groups: control group ( n = 16 ), diet intervention group ( n= 22), and combined interventions group ( n =29). The changes of BMI and body fat rate (BFR) were observed. Results BMI significantly decreased after interventions ( diet intervention group: P = 0. 000; combined interventions group: P = 0. 018 ); the change of BMI in diet intervention group was significantly larger than that in control group ( P = 0. 035 ). The trunk and body BFRs also significantly decreased after interventions (diet intervention group: P=0. 000, P = 0. 013; combined interventions group: P = 0. 000, P = 0. 000 ); the changes of trunk and body BFRs were significantly larger in combined interventions group than those in control group ( P = 0.005, P = 0. 003 ). Conclusion Diet intervention and combined interventions are both effective in achieving weight loss in adolescents, and combined interventions have superior effectiveness.

Introduction Milk is a good source of bioavailable calcium compared with other foods. Recent in vitro and in vivo studies have shown that milk whey protein, especially its basic protein fraction (milk basic protein, MBP), contains several components capable of promoting bone formation and inhibiting bone resorption. The objective of this study was to examine the effects of MBP on bone mineral density (BMD) and bone metabolism of healthy young women.Methods Eighty-four healthy young women were randomly assigned to three groups: control group, whole milk group or MBP group treated with milk containing 40 mg MBP for 8 months. The bone mineral density of total body, the lumbar vertebrae L2-L4 and the left forearm of each subject were measured by dual-energy X-ray absorptiometry (DEXA) at 0 and 8 months of treatment. Serum indexes of bone metabolism were measured at 0, 3, 6 and 8 months. Eighty-one subjects who completed the study in accordance with the protocol were included in the analysis.Results Total BMD in all groups significantly increased compared with baseline values. However, no significant difference on the mean rate of gain of total BMD was observed among the MBP group (2.19%), the whole milk group (2.63%) and the control group (1.61%). Serum crosslinked N-teleopeptides of type-I collagen (NTx) in MBP group at 8 months and in whole milk group at 6 months were significantly decreased from baseline. There were no significant differences between whole milk group and MBP group; however, after combining the milk groups, NTx had significantly decreased from baseline. No significant increase was observed in serum bone-specific alkaline phosphatase (BAP) in both whole milk group and MBP group.Conclusion No significant effect of MBP on bone mineral density and bone metabolism was observed, but milk supplementation was effective in suppressing bone resorption.