对住院患者进行传染病指标的检测,可以发现潜在的传染源,防止患者之间、医患之间的交叉感染,及时控制其在院内的传播流行,预防和减少医患纠纷的发生.因此,对入院患者进行血清学感染指标的检测已成为临床常规检验项目.

Objective:To learn value of allied examination of D-dimer P-selection and highsensitivity C-Reactive Protein for early diagnosis of diabetic nephropathy(DN).Methods:According to the results of urinary albumin excretion rate(UAER),125 cases of type,were divided into simple diabetic mellitus(SDM),early diabetic nephropathy(EDN) and clinical diabetic nephropathy(CDN),other 44 healthy persons were assigned as control group.D-dimer,P-selection andhigh-sensitivity C-Reactive Protein of all groups were examined.Results:There was significant difference of D-dimer,P-selection and high-sensitivity C-Reactive Protein in three groups(F=160.32,F=94.17,F=40.89;P 0.01).Moreover,with the progression of disease,the contents of D-dimer P-selection andhigh-sensitivity C-Reactive Protein were increasing gradually.The contents of D-dimer P-selection and high-sensitivity C-Reactive Protein were the highest in CDN group.D-dimer,P-selection and high-sensitivity C-Reactive Protein were positively correlated in straight line With UAER(R=0.742,0.751,0.792).Conclusion:D-dimer,P-selection and high-sensitivity C-Reactive Protein are closely related with the genesis and development of DN.Allied examination is very important for DN early diagnosis.

管型是蛋白、细胞或结晶等成分在远曲小管、集合管中凝固而成的圆柱结合物,在尿中出现常提示肾实质的损害,对泌尿系统疾病的诊断鉴别、病情观察及预后判断有一定意义[1].

Objective: To determine the clinical significance of the measurement of the plasma D-dimer in patients with lung cancer. Methods: The plasma levels of D-dimer were detected by colloidal gold method in one hundred and thirty-two lung cancer patients with different histologic types. There were also thirty healthy people in control group. Results: The plasma levels of D-dimer in lung cancer group were significantly higher than those of control group(t=1.992; P<0.05). They became higher with the proliferation of tumor metastasis, and there were marked differences among each group(t=1.192; P<0.05), but they were not correlated to histological classification.Conclusion: Activation of coagulation and fibrinolysis exist in lung cancer patients. The abnormal increase of the D-dimer level means the more possibility of metastasis especially when it rises continually. There appears to be the same levels of clotting activation according to histologic types of tumor. The measurement of the plasma D-dimer may has some help with the early diagnosis, treatment and the prognosis of the lung cancer.

目的:探讨肺癌患者血浆D-二聚体浓度的临床意义.方法:胶体金法检测132例不同病理类型的肺癌患者和30例健康体检者的血浆D-二聚体水平.结果:肺癌患者血浆D-二聚体水平显著高于正常对照组(t=1.992;P<0.05).随着肿瘤的扩散转移,血浆中D-二聚体水平明显升高,肺癌转移患者血浆D-二聚体水平相对未转移组有明显差异(t=1.192;P<0.05).不同病理类型的肺癌患者血浆D-二聚体水平差异无显著性.结论:肺癌患者存在着明显的凝血、纤溶激活状态.D-二聚体浓度异常升高的肺癌患者容易发生癌转移.不同病理类型肺癌患者的血浆D-二聚体水平无明显差异.血浆D-二聚体的检测对肺癌早期诊断、临床分期、预后判断可能有一定的帮助.

目的 探讨胸腔积液和血浆纤维蛋白原(fibrinogen,Fib)及D二聚体(D-dimer,D-D)检测在肺癌诊断中的价值.方法 选择恶性胸腔积液患者63例(研究组)与结核性胸腔积液患者60例(对照组),同时检测其血浆及胸腔积液中的D-D、Fib水平并进行统计学分析.结果 不同性别及年龄的肺癌患者胸腔积液及血浆中D-D、Fib水平差异均无统计学意义(P均>0.05);不同吸烟量患者胸腔积液及血浆中D-D、Fib水平差异均有统计学意义(P均<0.05);研究组胸腔积液中的D-D和Fib水平明显高于对照组,且差异均有统计学意义(P均<0.05),两组间血浆中Fib水平差异有统计学意义(P<0.05),而D-D水平差异无统计学意义(P>0.05);不同病理类型肺癌患者血浆及胸腔积液中D-D、Fib水平差异均无统计学意义(P均>0.05).结论 血浆和胸腔积液中D-D和Fib的检测对提高肺癌和恶性胸腔积液的检出率有重要临床价值.

UF-1000i全自动尿流式细胞分析仪具有检测快速、结果重复性良好、精密度、准确度高等优点.在提高检验人员工作效率的同时为临床疾病的诊断、治疗及疗效的观察提供了更多有价值的实验数据,为确保结果的准确性,使用UF-1000i全自动尿流式细胞分析仪要全面做好分析前、分析中、分析后的质量控制.笔者体会如下.1 分析前的质量控制1.1仪器安装环境 仪器安装不能在高温、高湿、多尘及日光直晒的位置,而应在通风良好位置适当的室内安装,使其性能得以充分发挥.仪器的电源线采用三相插头,工作环境温度15～30℃,相对湿度范围为30％～ 85％.