目的:观察双歧杆菌四联活菌片联合奥替溴铵片治疗腹泻型肠易激综合征患者的效果.方法:选取2018年3月至2020年3月新乡市第二人民医院126例腹泻型肠易激综合征患者进行前瞻性研究,按随机数字表法将患者分为对照组和研究组各63例.对照组采用奥替溴铵片治疗,研究组采用双歧杆菌四联活菌片联合奥替溴铵片治疗,比较两组临床疗效、治疗前后血清炎性因子[白细胞介素-2(IL-2)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率.结果:研究组治疗总有效率为96.83％(61/63),高于对照组的82.54％(52/63),差异有统计学意义(P<0.05);治疗后,两组血清IL-2、IL-6和TNF-α水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为3.17％(2/63),低于对照组的12.70％(8/63),差异有统计学意义(P<0.05).结论:双歧杆菌四联活菌片联合奥替溴铵片治疗腹泻型肠易激综合征患者可提高治疗总有效率,降低血清炎性因子水平和不良反应发生率,效果优于单纯奥替溴铵片治疗.

OBJECTIVE To study the value of combined detection of serum IL-6 ,IL-8 ,and TNF-αin prediction of early intrauterine infection due to premature rupture of membranes so as to provide guidance for diagnosis ,preven-tion ,and treatment of the early intrauterine infection .METHODS Totally 40 patients with early intrauterine infec-tion due to premature rupture of membranes who were treated in hospitals from Jun 2014 to Dec 2015 were chosen as the group A ,40 premature rupture of membranes patients without early intrauterine infection were assigned as the group B ,and 40 healthy pregnant women were set as the group C .The levels of serum IL-6 ,IL-8 ,and TNF-αwere compared among the three groups ,the test results were compared between the patients with full-term ges-tation and the patients without full-term gestation in the group A and the group B ,and the test results were com-pared among the patients with different severities of chorioamnionitis in the group A .RESULTS The levels of ser-um IL-6 ,IL-8 ,and TNF-αof the group A were respectively (13 .56 ± 1 .42)pg/ml ,(15 .78 ± 1 .69)pg/ml ,and (2 .29 ± 0 .24)ng/ml ,higher than (10 .04 ± 1 .20)pg/ml ,(12 .53 ± 1 .42)pg/ml ,and(1 .66 ± 0 .18)ng/ml of the group B as well as (6 .42 ± 0 .67)pg/ml ,(7 .85 ± 0 .78)pg/ml ,and (0 .91 ± 0 .13)ng/ml of the group C ;the levels of the above indexes of the group B were higher than those of the group C ,meanwhile ,the levels of the indexes of the pregnant women with or without full-term gestation were higher in the group A than in the group B ;there was significant difference in the test result among the patients with different severities of chorioamnionitis in the group A (P<0 .05) .CONCLUSION The value of combined detection of serum IL-6 ,IL-8 ,and TNF-αis high in the pre-diction of the early intrauterine infection due to premature rupture of membranes and its severity .

OBJECTIVE To investigate the effects of different anesthesia methods on infections ,immune function and the levels of serum interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α)in patients with abdominal surger-y .METHODS A total of 150 cases of patients with abdominal surgery were enrolled from Oct .2015 to Oct .2016 . The patients were divided into inhalation anesthesia group (group A ,n=50) ,total intravenous anesthesia group (group B ,n=50) ,and epidural anesthesia combined with general anesthesia (group C ,n=50) .The anesthesia effect ,postoperative infection ,immune function and the levels of serum IL-6 and TNF-A were compared among each group .RESULTS The postoperative infection rate in group C was lower than that in group A and group B (P<0 .05) ,while the recovery time and extubation time were shorter than those in group A and B ,and the postoper-ative infection rate recovery time and extubation time had no significant difference between group A and group B . The levels of CD3 + ,CD4 + ,and CD4 + /CD8 + in 3 groups at 6 hand 1 d after operation were significantly lower than those before operation ,and were restored to preoperative levels at 3 d after operation(P<0 .05) .The levels of CD3 + ,CD4 + ,and CD4 + /CD8 + in group C were higher than those in group A and group B at 6 h and 1 d after operation ,while those in group A and B had no significant difference .The levels of serum IL-6 and TNF-α in group C were lower than those in group A and group B at 6 h and 1 d after operation (P<0 .05) ,but there was no significant difference between group A and group B .CONCLUSION Epidural anesthesia combined with general an-esthesia is beneficial to early extubation in patients with surgery ,it can relieve immunosuppression and decrease the postoperative levels of serum inflammatory factors in patients ,which may help to reduce postoperative infec-tion .

目的 探讨中式低脂饮食对离子选择电极法检测锂盐浓度的影响.方法 对13例使用锂盐治疗达稳态的住院躁狂症患者,采用离子选择电极法比较空腹与正常饮食后静脉血锂盐浓度的差异性.结果 患者空腹血清锂盐浓度为(0.61±0.26) mmol·L-1,正常饮食后血清锂盐浓度为(0.64±0.27) mmol·L-1,两者比较差异无显著性(P＞0.05),两者结果呈高度线性相关(r=0.976,P＜0.01).结论 中式低脂饮食不影响离子选择电极法对锂盐浓度的检测.

医学基础检验专业的实习生存在对检验项目的原理及临床应用掌握不好,对检验报告的综合分析能力不强等问题,难以满足社会对高素质检验医师的需求.本文从实习生存在的问题、检验操作及流程等方面提出了临床实习建议,旨在提高医学检验专业实习生的临床检验技能.

OBJECTIVE To study and observe the expression levels of blood inflammatory factors of patients with bladder cancer and infection ,in order to provide evidence for the treatment measures of the patients .METHODS A total of 45 patients with bladder cancer and infection from Dec .2014 to Apr .2016 were set as group A ,45 patients with bladder cancer and without infection at the same time were set as group B ,and 45 healthy persons were set as group C .The serum anti-inflammatory and pro-inflammatory factors levels of the three groups were detected ,then the detection levels of the three groups ,group A and group B with different stages of bladder cancer were com-pared .RESULTS The serum pro-inflammatory factors IL-4 ,IL-10 ,IL-37 and APN of group A were(2 .21 ± 0 .25) ng/ml ,(30 .68 ± 3 .27)pg/ml ,(50 .17 ± 3 .34)pg/ml and(4 .18 ± 0 .52)mg/L ,respectively ,which were all worse than those of group B ,and the levels of group B were all worse than those of group C ,and there were significant differences (P<0 .05) .CONCLUSION The expression levels of blood inflammatory factors of patients with blad-der cancer and infection show obviously abnormal ,and the influence of the infection for those indexes of patients with different stages of bladder cancer are great ,so they should be paid to more attention .

目的 评价血清人附睾蛋白4(HE4)和PSA检测对前列腺癌的诊断价值.方法 分别测定79例前列腺癌患者组和111例男性健康对照组血清HE4和PSA水平,并对检测结果进行分析.结果 与男性健康对照组比较,前列腺癌患者组前列腺癌PSA<4者,HE4与正常对照组相比无显著性差异;前列腺癌PSA 4.0-10.0与前列腺癌PSA>10.0两组患者中,HE4检测数据与男性健康对照组相比,均有显著升高(P<0.01).结论 前列腺癌患者血清HE4与PSA的升高呈正相关,证实HE4与前列腺癌的发生发展有密切的关系,提示HE4在前列腺癌的诊断、疗效评价及鉴别诊断上有一定的临床价值.

OBJECTIVE To investigate the correlation of the non-high density lipoprotein cholesterol (non-HDL-C) and hypertension and its clinical significance. METHODS Detected the lipids of 198 cases of hypertension group and 247 cases of the normal control group, and calculated non-HDL-C, compared and analyzed its clinical significance of detecting non - HDL-C in hypertensive patients. RESULTS The mean value of non-HDL-C in the disease group (3.87 ± 0.83) mmol / L was higher than the value from the control group (3.68 ± 0.92) mmol / L, and they had significant differences (P﹤0.05). CONCLUSION Non-HDL-C is an useful evaluation tool to assess hypertension risk.

我国是乙型肝炎病毒(HBV)感染率较高的国家,大部分感染者为无临床症状的HBV携带者,而HBV与肝硬化、原发型肝癌有密切关系.加之精神病医院的特殊管理模式,精神病患者由于受精神症状支配,因意外发生皮肤破损的情况较常见,因而患者易发生HBV感染,严重威胁患者的健康.为了解住院精神病患者HBV感染状况,作者对在我院住院精神病患者HBV五项指标进行了检测分析,现将结果报告如下.