Breast cancer (BC) remains the most frequently diagnosed cancer and the second leading cause of cancer-related mortality among women worldwide. Medical imaging is essential in the diagnosis and management of BC, delivering crucial information about tumor location, heterogeneity, and metastatic progression. Nuclear medicine imaging offers non-invasive functional assessment through probes, which capture biological characteristics of tumors more effectively than conventional structural imaging modalities such as CT or MRI. The identification of specific molecular targets has become pivotal for accurate tumor subtyping, prognosis assessment, and tailoring effective therapies. In this review, these molecular targets are classified according to a three-dimensional spatial framework of BC, encompassing (1) intracellular metabolic processes, (2) cell-surface receptor expression, and (3) the extracellular TME. Through multi-dimensional targeting approaches from intracellular processes to microenvironmental networks, nuclear medicine imaging decodes BC biology: metabolism imaging reveals core cellular functions, receptor imaging identifies actionable therapeutic targets and evaluates molecular expression levels, and TME imaging elucidates complex microenvironmental interactions. Collectively, this spatially-informed targeting strategy allows for the non-invasive evaluation of therapeutic targets, assessment of tumor heterogeneity, and dynamic monitoring of treatment response. Furthermore, these advances are increasingly extending beyond diagnostics toward theranostic applications, where diagnostic probes are paired with therapeutic radionuclides to enable image-guided radioligand therapy. By consolidating current knowledge and outlining future directions, this review aims to inform both clinical practice and the development of next-generation imaging and theranostic platforms in precision oncology.

Cardiovascular diseases (CVDs) remain the leading cause of global mortality, with mitochondrial dysfunction serving as a central pathological hub in conditions such as atherosclerosis, myocardial ischemia-reperfusion injury and heart failure. Current mitochondrial-regulating drugs are severely limited by low bioavailability, short duration of action, poor targeting specificity and off-target effects, highlighting an urgent need for precise delivery systems. Nanocarriers, with tunable physicochemical properties and surface functionalization potential, enable hierarchical targeting of diseased cardiac tissues and mitochondria, offering a novel solution to overcome these limitations. Preclinical models have shown promising efficacy, particularly in alleviating oxidative stress damage in ischemic cardiomyopathy, improving energy metabolism in heart failure and promoting tissue repair. These encouraging results have sparked growing interest in the application of nanomaterials for mitochondrial-targeted diagnosis and treatment of CVDs. This review first outlines the role of mitochondrial dysfunction in CVD pathogenesis, covering impaired oxidative phosphorylation, excessive reactive oxygen species production, disrupted mitochondrial dynamics and defective mitophagy. It, then, focuses on the design strategies of nanotherapeutics based on a hierarchical targeting concept, encompassing the selection of biocompatible carriers, optimization of size and morphology, tissue or cell-specific targeting modifications, mitochondrial ligand modifications, as well as the loading and therapeutic mechanisms of various therapeutic agents. Furthermore, it provides an in-depth analysis of key physiological barriers such as hemodynamic shear stress, endothelial barrier and extracellular matrix hindrance, along with intracellular trafficking challenges including lysosomal escape and immune clearance, which all impact delivery efficiency. This review aims to offer insights to advance the rational development and clinical translation of mitochondria-targeted nanomedicines for CVDs.

Photothermal therapy (PTT) is a promising strategy for cancer treatment, yet traditional high-temperature PTT (>50 °C) often induces heat shock protein (HSP) overexpression and exacerbates tumor hypoxia, particularly in triple-negative breast cancer (TNBC), thereby promoting therapeutic resistance and limiting efficacy. In contrast, mild PTT (<45 °C) has gained increasing attention for its ability to exert therapeutic effects while minimizing damage to surrounding normal tissues. Herein, we developed a biomimetic nanoplatform, tFBSG@M BNPs, to enhance mild PTT through a cascade-amplified synergistic mechanism tailored to the TNBC microenvironment. By coating iron-doped bismuth sulfide nanoparticles with tumor cell membranes for homologous targeting, this nanoplatform integrates three interconnected therapeutic actions: (1) Mild PTT, alleviates hypoxia by improving local blood flow and oxygen supply, both reducing HSP-mediated thermotolerance and preparing the tumor microenvironment for downstream catalysis. (2) Higher oxygen levels boost GOx-mediated starvation therapy, depleting glucose and generating H2O2, which not only disrupts tumor metabolism but also serves as a substrate for further oxidative amplification. (3) H2O2 is catalytically converted by Fe2+ centers into •OH via a Fenton reaction, unleashing potent oxidative stress that completes the self-amplifying cascade and drives apoptosis. This cascade-driven approach achieved a 96.52 % tumor volume reduction under NIR irradiation. MRI showed a 190 % increase in T1 signal at the tumor site, confirming nanoparticle accumulation; CT provided a 24.7 HU contrast enhancement for clear boundary mapping; and PA imaging visualized tumor vasculature and blood oxygen saturation. By uniting mild PTT, metabolic disruption, and ROS amplification in a single tumor-targeted platform, tFBSG@M BNPs offer a promising strategy to overcome TNBC resistance and improve therapeutic outcomes. STATEMENT OF SIGNIFICANCE: 1. A cascade-amplified therapeutic mechanism that overcomes TNBC's hypoxia, HSP-mediated thermotolerance, and antioxidant defenses through the integration of mild photothermal therapy, GOx-mediated starvation, and Fenton reaction-driven chemodynamic therapy. 2. A multifunctional nanoplatform (tFBSG@M BNPs) that combines iron-doped Bi2S3, glucose oxidase, and homologous tumor membranes, achieving 96.52 % tumor suppression and a 7.4-fold increase in ROS under mild PTT in an orthotopic TNBC model. 3. A clinically adaptable multimodal imaging strategy, combining CT, MRI, and PA imaging in a stepwise fashion to guide therapy with precise boundary mapping, soft tissue resolution, and vascular visualization.

Sonodynamic therapy (SDT) relies heavily on the presence of oxygen to induce cell death. Its effectiveness is thus diminished in the hypoxic regions of tumor tissue. To address this issue, the exploration of ultrasound-based synergistic treatment modalities has become a significant research focus. Here, we report an ultrasonic cavitation effect enhanced sonodynamic and 1208 nm photo-induced cancer treatment strategy based on thermoelectric/piezoelectric oxygen-defect bismuth oxychloride nanosheets (BNs) to realize the high-performance eradication of tumors. Upon ultrasonic irradiation, the local high temperature and high pressure generated by the ultrasonic cavitation effect combined with the thermoelectric and piezoelectric effects of BNs create a built-in electric field. This facilitates the separation of carriers, increasing their mobility and extending their lifetimes, thereby greatly improving the effectiveness of SDT and NIR-Ⅱ phototherapy on hypoxia. The Tween-20 modified BNs (TBNs) demonstrate ∼88.6% elimination rate against deep-seated tumor cells under hypoxic conditions. In vivo experiments confirm the excellent antitumor efficacy of TBNs, achieving complete tumor elimination within 10 days with no recurrences. Furthermore, due to the high X-ray attenuation of Bi and excellent NIR-Ⅱ absorption, TBNs enable precise cancer diagnosis through photoacoustic (PA) imaging and computed tomography (CT).

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Its pathogenesis involves aberrant activation and aggressive proliferation of fibroblast-like synoviocytes (FLS), excessive macrophage infiltration, and disrupted M1/M2 macrophage polarization within the synovial microenvironment (SME). However, current therapies remain inadequate for precise SME modulation, often leading to limited efficacy and poor prognosis. To address this challenge, we developed a multifunctional nanocapsule, termed RP/HP@Mn/L, which is composed of a low molecular weight heparin (LMWH)-modified, Mn2+-doped hollow mesoporous polydopamine (HP) nanocarrier co-loaded with rapamycin (Rap) and paeoniflorin (Pae). This nanocapsule's dual-ligand strategy targets P-selectin on inflamed endothelial cells and integrin αM on inflammatory macrophages, enabling precise spatiotemporal accumulation at the pathological site. This nanocapsule enables spatiotemporally specific targeting of both inflammatory endothelial cells and inflammatory macrophages, thereby enhancing precise drug delivery to pathological sites. Mechanistic investigations revealed that RP/HP@Mn/L, in combination with mild photothermal therapy (PTT) mediated by HP, effectively suppressed FLS proliferation and invasion. Concurrently, it promoted the polarization of macrophages from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. These synergistic effects facilitated the remodeling of the SME, thereby alleviating synovitis and enhancing bone repair in RA. In conclusion, this study proposes a spatiotemporally targeted combinatorial nanotherapeutic strategy that integrates multimodal mechanisms for SME modulation. This approach represents a promising therapeutic platform for improving outcomes in RA and other autoimmune disorders.

Iron-based nanomaterials (INMs), due to their particular magnetic property, excellent biocompatibility, and functionality, have been developed into powerful tools in both tumor diagnosis and therapy. We give an overview here on how INMs such as iron oxide nanoparticles, element-doped nanocomposites, and iron-based organic frameworks (MOFs) display versatility for tumor imaging and therapy improvement. In terms of imaging, INMs improve the sensitivity and accuracy of techniques such as magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) and support the development of multimodal imaging platforms. Regarding treatment, INMs play a key role in advanced strategies such as immunotherapy, magnetic hyperthermia, and synergistic combination therapy, which effectively overcome tumor-induced drug resistance and reduce systemic toxicity. The integration of INMs with artificial intelligence (AI) and radiomics further expands its capabilities for precise tumor identification, and treatment optimization, and amplifies treatment monitoring. INMs now link materials science with advanced computing and clinical innovations to enable next-generation cancer diagnostics and therapeutics.

Stem cell therapy is being explored as a potential treatment for idiopathic pulmonary fibrosis (IPF), but its effectiveness is hindered by factors like reactive oxygen species (ROS) and inflammation in fibrotic lungs. Moreover, the distribution, migration, and survival of transplanted stem cells are still unclear, impeding the clinical advancement of stem cell therapy. To tackle these challenges, we fabricate AuPtCoPS trimetallic-based nanocarriers (TBNCs), with enzyme-like activity and plasmid loading capabilities, aiming to efficiently eradicate ROS, facilitate delivery of therapeutic genes, and ultimately improve the therapeutic efficacy. TBNCs also function as a computed tomography contrast agent for tracking mesenchymal stem cells (MSCs) during therapy. Accordingly, we enhanced the antioxidant stress and anti-inflammatory capabilities of engineered MSCs and successfully visualized their biological behavior in IPF mice in vivo. Overall, this study provides an efficient and forward-looking treatment approach for IPF and establishes a framework for a stem cell–based therapeutic system aimed at addressing lung disease.

Chemodynamic therapy (CDT) exhibits unsatisfactory therapeutic efficacy for colorectal cancer (CRC) due to the hyposensitive Fenton reaction. Herein, we constructed a novel multifunctional nanoplatform based on bismuth-doped iron selenide nanoparticles (BFS NPs) for promoting the therapeutic performance of CDT on CRC. BFS NPs can realize CDT and second near-infrared photothermal therapy (NIR-II PTT) by means of the Fenton reaction and an excellent photothermal conversion efficiency (eta = 31.9%). Moreover, the rising temperature induced by NIR irradiation accelerates the Fenton reaction rate because of there being more activated H2O2, thereby improving reactive oxygen species (ROS) levels to address the insufficient hydrogen peroxide concentration. The results showed that the combination of CDT with NIR-II PTT significantly inhibits the growth of CRC and minimizes adverse reactions. Meanwhile, bismuth doping endows the BFS NPs with superior CT imaging and T2-weighted magnetic resonance imaging (T2-MRI) capacities. These unique properties offer an appropriate treatment time window for guiding NIR-II PTT. In summary, this nanoplatform improves the therapeutic effect of CDT and accurately regulates NIR-II PTT by MRI/CT imaging guidance, which provides a new perspective for effective and precise therapy of CRC.

The conventional treatment methods used for the management of autoimmune diseases (ADs) have limited efficacy and also exhibit significant side effects. Thus, identification of novel strategies to improve the efficacy and safety of ADs treatment is urgently required. Overactivated immune response and oxidative stress are common characteristics associated with ADs. Polydopamine (PDA), as a polymer material with good antioxidant and photothermal conversion properties, has displayed useful application potential against ADs. In addition, PDA possesses good biosafety, simple preparation, and easy functionalization, which is conducive for the pharmacological development of PDA nanomaterials with clinical transformation prospects. Here, we have first reviewed the preparation of PDA, the different functional integration strategies of PDA-based biomaterials, and their potential applications in ADs. Next, the mechanism of action of PDA in ADs has been elaborated in detail. Finally, the application opportunities and challenges linked with PDA nanomaterials for ADs treatment are discussed. This review is contributed to design reasonable and effective PDA nanomaterials for the diagnosis and treatment of ADs.

Owing to their versatility, fluorescent carbon quantum dots (CQDs) have attracted significant attention for applications in sensors, bioimaging, microfluidics, photodynamic therapy, drug delivery, light-emitting diode, etc. Herein, nitrogen and lanthanum co-doped multifunctional lignin-based carbon quantum dots ((N, La)-CQDs) were prepared from enzymatic hydrolysis lignin using a simple one-step hydrothermal method. The diameter of the CQDs obtained was about 2.2 nm with a good water solubility at the excitation wavelength of around 365 nm and emission wavelength of around 465 nm. This is the first discovery of (N, La)-CQDs to detect Sn2+. (N, La)CQDs were successfully used to detect Fe3+, Sn2+, and ClO- ions in the range of 0-100 & mu;M with the detection limits of 0.99 & mu;M, 1.1 & mu;M and 1.1 & mu;M sequentially, and the linear fit R2 of 0.9997, 0.9943 and 0.9941 respectively. Non-cytotoxic (N, La)-CQDs can be used for labeling cells and detecting Sn2+ in zebrafish. These attractive features make these non-toxic, environmentally friendly CQDs material highly promising for applications in a wide range of areas, such as biomedicine, biosensing, disease diagnosis, and environmental monitoring.

三阴性乳腺癌是乳腺癌特殊病理亚型,不表达雌激素受体、孕激素受体和人类表皮生长因子受体-2,因此可选择的临床治疗手段不多.该肿瘤侵袭性强,易复发和转移,预后较差.早期诊断和精准评估对该肿瘤的治疗有重要临床价值.MRI因其较高的软组织分辨率、多序列多方位成像特点、动态血流灌注等优势是目前乳腺癌的常用影像学检查方法.近年来MRI对三阴性乳腺癌的诊断和评估有了进一步的发展.本文就此做一综述,旨在提高对该检查的认识.

Tumor targeting drug delivery is of significant importance for the treatment of triple negative breast cancer (TNBC) considering the presence of appreciable amount of tumor matrix and the absence of effective targets on the tumor cells. Hence in this study, a new therapeutic multifunctional nanoplatform with improved TNBC targeting ability and efficacy was constructed and used for therapy of TNBC. Specifically, curcumin loaded mesoporous polydopamine (mPDA/Cur) nanoparticles were synthesized. Thereafter, manganese dioxide (MnO2) and a hybrid of cancer-associated fibroblasts (CAFs) membranes as well as cancer cell membranes were sequentially coated on the surface of mPDA/Cur to obtain mPDA/Cur@M/CM. It was found that two distinct kinds of cell membranes were able to endow the nano platform with homologous targeting ability, thereby achieving accurate delivery of drugs. Nanoparticles gathered in the tumor matrix can loosen the tumor matrix via the photothermal effect mediated by mPDA to rupture the physical barrier of tumor, which is conducive to the penetration and targeting of drugs to tumor cells in the deep tissues. Moreover, the existence of curcumin, MnO2 and mPDA was able to promote the apoptosis of cancer cells by promoting increased cytotoxicity, enhanced Fenton-like reaction, and thermal damage, respectively. Overall, both in vitro and in vivo results showed that the designed biomimetic nanoplatform could significantly inhibit the tumor growth and thus provide an efficient novel therapeutic strategy for TNBC.

The intrinsic high X-ray attenuation and insignificant biological toxicity of Bi-based nanomaterials make them a category of advanced materials in oncology. Bi-based two-dimensional nanomaterials have gained rapid development in cancer diagnosis and treatment owing to their adjustable bandgap structure, high specific surface area and strong NIR absorption. In addition to the single functional cancer diagnosis and treatment modalities, Bi-based two-dimensional nanomaterials have been certified for accomplishing multi-imaging guided multifunctional synergistic cancer therapies. In this review, we summarize the recent progress including controllable synthesis, defect engineering and surface modifications of Bi-based two-dimensional nanomaterials for cancer diagnosis and treatment in the past ten years. Their medical applications in cancer imaging and therapies are also presented. Finally, we discuss the potential challenges and future research priorities of Bi-based two-dimensional nanomaterials.

基于大数据背景下我国高校图书馆学科服务机遇和挑战并存的现状,分析了现如今高校图书馆学科服务所存在的问题,提出了行之有效的发展对策,旨在为我国高校图书馆学科服务工作提供一定的参考价值.

The absence of effective therapeutic targets and tumor hypoxia are the main causes of failure in the treatment of triple-negative breast cancer (TNBC). Biomimetic nanotechnology and tumor microenvironment (TME) responsiveness bring hope and opportunity to address this problem. Here, we develop a core membrane nanoplatform (HM/D-I-BL) using hollow mesoporous manganese dioxide (HM) coated with a biomimetic cancer cell membrane for enhanced chemotherapy/phototherapy via the strategy of precise drug delivery and hypoxia amelioration. Cancer cell membrane modification endows HM/D-I-BL with excellent homologous targeting and immune escape performance. Cellular uptake and fluorescence imaging studies confirmed that HM/D-I-BL can be accurately delivered to tumor sites. HM/D-I-BL also features efficient in situ O2 generation in tumors upon laser irradiation, and subsequently enhanced chemotherapy/phototherapy, pointing to its usefulness as a TME-responsive nanozyme to alleviate tumor hypoxia in the presence of H2O2. In addition, HM/D-I-BL showed good fluorescence and magnetic resonance imaging performances, which offers a reliable multimodal image-guided combination tumor therapy for precision theranostics in the future. In general, this intelligent biomimetic nanoplatform with its homotypic tumor targeting, in situ alleviation of tumor hypoxia and synergetic chemophototherapy would open up a new dimension for the precision treatment of TNBC.

信息化时代,新科技和多媒体技术迅速发展,图书馆的管理模式也在不断进步.为了更好地适应网络信息化时代人们的阅读需求,就必须对高校图书资料管理进行改革.作为网络信息化时代前沿的高等院校,应该发挥自身的优势,完善传统的图书馆管理制度,推动建设智慧图书馆,为人们创造更好的阅读体验.

利用文献调查法对国内中医药院校图书馆开展学科服务研究进行调查分析,目前中医药图书馆开展学科服务主要围绕政策导向性的学科服务理论研究、学科服务模式的实践研究以及学科馆员的研究展开.文章基于文献调查的结果对中医药高校图书馆在学科服务领域提出建议,中医药高校图书馆可以从合理地制定发展规划出发,有针对性地培养学科馆员,构建学科服务平台,开发利用古籍资源等方面展开工作,为中医药事业的发展提供助力.

文章首先阐述了高校图书馆思政教育工作现状,然后提出了后疫情时代高校图书馆思政教育的实践路径,包括提供思政特色知识服务、搭建思政学科导航、设计思政书目检索系统、构建文献检索课程思政体系、优化思政教育阅读推广活动.