目的观察解毒化瘀汤合乌梅承气汤治疗慢性乙型肝炎慢加急（亚急）肝衰竭早中期的临床疗效。方法将慢性乙型肝炎慢加急（亚急）肝衰竭患者80例随机分为两组，治疗组40例口服解毒化瘀汤合乌梅承气汤保留灌肠，并配合常规西医治疗；对照组40例予常规西医治疗。比较两组治疗后症状、体征、肝功能、凝血酶原活动度（PTA）、血氨（NH3）改善情况。结果治疗组疗效优于对照组，其总胆红素（TBIL）、丙氨酸氨基转移酶（ALT）、NH3明显降低，PTA升高，与对照组比较差异显著；特别在改善肠道感染、肝性脑病方面，治疗组疗效优于对照组。结论解毒化瘀汤合乌梅承气汤能提高慢性乙型肝炎慢加急（亚急）肝衰竭早中期的疗效，改善其并发症。

目的观察解毒化瘀汤治疗肝炎高胆红素血症的临床疗效.方法将60例肝炎高胆红素血症患者随机分为治疗组30例、对照组30例.治疗组用解毒化瘀汤,对照组用促肝细胞生长素,用药疗程为4周.观察肝功能生化指标TBIL、ALT、AST、TBA、TP、ALB、ETM的变化.结果解毒化瘀汤组患者肝功能改善、降低内毒素水平、黄疸的消退均优于对照组.治疗组显效率为76.67%,对照组为50.00%,两组疗效比较差异有显著性(P＜0.05).结论解毒化瘀汤有明显退黄、降酶和降低内毒素水平的作用.

Objective:To observe the effects of Jiedu Huayu Decoction.Methods:60 patients with hyperbilirubinemia induced by hepatitis were divided into two groups randomly, 30 patients in treating group and 30 patients in control group. The treating group were treated by Jiedu Huayu Decoction,and the control group were treated by hepatocyte growth-promoting factors for injection, Patients were treated for 4 weeks. Biochemical indexes of liver function, such as TBil,ALT,AST,DBil,ETM were observed.Results:The effects of improving liver function, lowering the level of endotoxin and subsiding icterus of treating group were better than those of control group;the total efficiency rate of treating group was 90%,the total efficiency rate of control group was 76.67%, the difference of the effect of subsiding icterus between the two groups was significant P0.01);the improving of some clinical symptoms of treating group was better than control group(P0.05 or P0.01).Conclusion:Jiedu Huayu Decoction can obviously subsiding icterus, and lowering the levels of TBil,ALT,AST,DBil,ETM and the level of endotoxin.

目的观察解毒化瘀汤治疗肝炎高胆红素血症并发内毒素血症(ETM)的临床疗效.方法采用解毒化瘀汤治疗ETM患者30例,并与茵栀黄口服液治疗30例作对照.观察治疗后的总有效率、肝功能及血浆内毒素的变化.结果治疗组总有效率(90.00%)优于对照组(76.67%)(P<0.05),且清除血浆内毒素与治疗前比较,差异有显著性(P<0.05),改善肝功能方面与对照组比较,亦有显著差异(P<0.05).结论解毒化瘀汤治疗肝炎高胆红素血症并发内毒素血症疗效显著,其主要机制与降低血中内毒素水平有关.

Objective: To observe the effects of Jiedu Huayu Decoction in treating hyperbilirubinemia induced by hepatitis. Methods: 60 patients with hyperbilirubinemia induced by hepatitis were diveded into two groups randomly. The therapeutic group were treated by Jiedu Huayu Decoction, and the control group were treated by Yinzhihuang Oral liquids. Then, compare the effect between the two groups by observing the change of clinical symptoms, liver function, endotoxin. Results: The remarkable effective rate of the therapeutic group was better than that of control group (P0.01). TBil、TEA were obviously decreased and TP、Alb increased distinctly in the therapeutic group. Meanwhile, the level of endotoxin descended markedly. Compared with the control group there was significant difference (P0.05 or0.01). Conclusion: The curative effect of Jiedu Huayu Decoction on hyperbilirubinemia induced by hepatitis is obvious.