Objective To investigate the effects of metformin on hepatic inflammation, liver fibrosis and insulin resistance in patients with type 2 diabetes mellitus ( T2DM) complicated by nonalcoholic fatty liver disease ( NAFLD). Methods A total of 70 patients with T2DM complicated by NAFLG who were admitted and treated in our hospital from June 2011 to May 2016 were divided into observation group ( n =35 ) and control group ( n =35 ) according to random number table. The patients in control group were treated by diet and exercise only,however,the patients in observation group,on the basis of control group,were treated by oral metformin. After 12-week treatment, the levels of tumor necrosis factor-α( TNF-α), interleukin 6 (IL-6), high sensitivity C reactive protein (hs-CRP), triglyceride (TG), total cholesterol (TC), high density lipoprotein ( HDL-C ) , low density lipoprotein ( LDL-C ) , alanine transferase ( ALT ) , aspartate aminotransferase (AST), type Ⅲ procollagen (PCⅢ), type Ⅳ collagen (Ⅳ-C), hyaluronic acid (HA), laminin (LN), fasting plasma glucose (FPG), 2h postprandial blood sugar glucose (2 hPG), glycosylated hemoglobin (HbA1c), fasting insulin (Fins), insulin resistance index ( HOMA-IR ) and incidence of adverse reactions before and after treatment were observed and compared between the two groups. Results After treatment, the indexes of serum inflammatory factors ( TNF-α, IL-6, hs-CRP) , indexes of blood lipid and liver function ( TC, TG, LDL-C, ALT, AST) , indexes of liver fibrosis ( PCⅢ,Ⅳ-C, LN, HA) and indexes of blood glucose and insulin (FPG, 2 hPG, Fins, HbA1c and HOMA-IR) were significantly decreased in both groups, as compared with those before treatment (P<0. 05). Moreover these indexes mentioned above in observation group were significantly lower than those in control group (P<0. 05), however the levels of HDL C in observation group were significantly higher than those in control group (P<0. 05). In addition there was no significant difference in incidence rate of adverse reactions during treatment between two groups (P>0. 05). Conclusion Metformin can significantly improve hepatic inflammatory reactions of patients with T2DM complicated by NAFLD, relieve liver fibrosis, reduce insulin resistance of body, which is conducive to control blood glucose smoothly, without increasing adverse reactions of patients.

目的：探讨低温超高频电波刀（Leep刀）联合重组人干扰素α－2b阴道泡腾胶囊及胸腺五肽对女性复发性生殖器尖锐湿疣（ CA）的临床疗效。方法将96例复发性女性生殖器CA患者随机分为对照组和治疗组，均使用Leep刀祛除疣体后分别给予干扰素α－2b阴道泡腾胶囊及干扰素α－2b阴道泡腾胶囊联合胸腺五肽的治疗。连续随访12个月，观察并比较2组患者治疗效果、复发情况及不良反应。结果治疗组患者的治愈率和总有效率均高于对照组，2组比较差异有统计学意义（ P ＜0⒃．05）。治疗组总复发率明显低于对照组（6．25％，18．75％）、平均复发时间明显长于对照组[（241．0±89．0）d，（135．6±77．5）d]，差异有统计学意义（ P ＜0．05）。2组患者不良反应均轻微，可以耐受。结论 CA患者经该三联方案联合治疗，能够明显降低复发率，延长复发时间，很好地促进患者尖锐湿疣的痊愈，且无增加不良反应的发生，具有良好的临床效果。

目的：探讨干扰素α-2b阴道泡腾胶囊联合甘露聚糖肽在治疗以及预防尖锐湿疣复发中的作用及其不良反应。方法2011年6月至2012年12月诊断为尖锐湿疣（ CA ）的患者90例随机分为对照组和治疗组，均使用LEEP刀切除疣体后分别给予甘露聚糖肽胶囊及甘露聚糖肽胶囊联合阴道用重组人干扰素α-2b泡腾胶囊的治疗。评价两组患者的临床疗效，随访6个月后、比较2组患者的复发情况及不良反应。结果治疗组患者有效率97．87％、复发率为2．13％，对照组患者有效率83．7％、复发率为16．2％。治疗组患者的复发率低于对照组，差异有统计学意义（ P ＜0．05）。且2组患者的不良反应轻微，均可以耐受。结论在LEEP刀手术基础上，给予患者口服甘露聚糖肽联合阴道用重组人干扰素α-2 b的治疗能够显著提高疗效，有效清除Hpv亚临床感染，降低复发率，且无增加不良反应的发生，值得临床推广应用。

目的：观察重组人干扰素α-2b阴道泡腾胶囊用于宫颈电热圈环切术（ leep）后治疗宫颈高危型人乳头瘤病毒（ HPV）感染的临床疗效。方法针对在我院宫颈病变门诊进行leep手术治疗的患者，选取术前检测有高危型HPV感染的患者96例，随机分为2组：治疗组48例，于leep术后加用重组人干扰素α-2b阴道泡腾胶囊治疗3个疗程；同时将单纯行leep术治疗的48例患者作为对照组。于术后第4、6、8周复查，分别观察2组患者宫颈创面愈合时间、术后并发症的发生情况等，于术后6个月再次进行宫颈HPV检测。结果2组患者宫颈创面愈合时间、并发症发生情况比较差异有统计学意义（ P ＜0 m．05）；高危型HPV清除率治疗组患者明显高于对照组，2组比较差异有统计学意义（ P ＜0．01）。结论 leep术后加用重组人干扰素α-2b阴道泡腾胶囊治疗，能显著提高宫颈高危型HPV感染清除率，并且宫颈创面愈合时间有缩短，术后颈管内膜肉芽增生等并发症明显减少，临床效果较好，值得在平时工作中推广应用。

目的探讨普通人群中胰岛素抵抗与习惯性流产的相关性。方法选择能除外明显原因的习惯性流产患者,测定其体内胰岛素水平,存在胰岛素抵抗的给予相应的治疗,观察其妊娠后的流产率。结果存在胰岛素抵抗的患者,经过二甲双胍治疗后流产率有明显下降,差异有统计学意义(P<0.01)。结论多囊卵巢综合征(PCOS)患者与普通人群中的习惯性流产患者均存在胰岛素抵抗者。治疗胰岛素抵抗可能有助于减少自然流产率,提高妊娠成功率。

宫颈磨烂为妇科常见病,对中、重度宫颈糜烂的治疗,目前常采用激光、电熨、冷冻及波姆灯光等物理疗法,虽然疗效稳定,但创面愈合时间长,阴道排液多,且又伴有创面结痂脱落后的阴道流血,患者不易接受.为寻求加快创面愈合,减少阴道流血及排液的方法,我们对采用波姆灯光治疗后的病人,加用保妇康泡沫剂进行观察,取得了较好的效果.

目的:回顾米非司酮配伍米索终止中期妊娠的经验,并对这种方法的有效性进行评价.方法:1996年1月至2001年12月于我院要求终止中期妊娠的592例妇女.所有的妇女先口服200mg米非司酮,36h后,于阴道后穹隆一次性放置600μg米索.如果放置米索后24h内未流产,则再次于阴道后穹隆放置600μg米索.如果自第一次放置米索后48h内未流产,则属引产失败.结果:592例妇女的平均孕周(中位数)为17周(范围:12～26周).平均引流时为7.5h(0.8～46.2 h).92.5%(534/577)的妇女应用米索后在24h内流产,99.5%(574/577)的妇女在36h内流产.本研究的引产成功率为98.5%(577/586).因胎盘或胎膜残留而接受清宫术的妇女为196例(34.0%).无宫颈裂伤等并发症的发生.结论:用200mg米非司酮进行预处理,阴道内一次放置600μg米索是一种安全有效的终止中期妊娠的方法,便于使用.