从不寐的病因病机及辨证论治两个角度进行分析,并结合神阙穴中药贴敷的临床应用情况,探讨了神阙穴中药贴敷治疗不寐的机理.

目的:探讨复方浙贝颗粒对难治性急性白血病围化疗期生活质量的影响.方法:采用随机、双盲、安慰剂对照、多中心临床研究的方法.统一拟定难治性急性白血病固化疗期诊断标准、临床研究方案和病例观察表.设立治疗组118例与对照组117例,使用标准化疗方案,同时于化疗前3d加用复方浙贝颗粒或模拟剂,每次1袋,每日2次,连续给药14 d.以一个标准化疗疗程为治疗周期,采用卡诺夫斯基(Kamofsky,KPS)评分进行疗效观察.结果:KPS评分两组比较无显著差异(P＞0.05),两组治疗前后比较,差异有统计学意义(P＜0.05),治疗期间KPS评分呈下降趋势.结论:复方浙贝颗粒联合1个疗程化疗在改善难治性急性白血病患者生活质量方面作用不明显.

OBJECTIVE To observe the effect of compound granule prescription of thunberg fritillary bulb in relieving the post-chemotherapy bone marrow depression in refractory acute leukemia (RAL) patients. METHOD Two hundred and thirty eight RAL patients collected from 7 third-grade class-A hospitals were randomly divided into the treatment group and the control group. Both groups were treated with conventional chemotherapy. They were administered with compound granule prescription of thunberg fritillary bulb or placebo three days before chemotherapy for consecutively 14 days. A standardized chemotherapy course was a treatment cycle. The changes in peripheral hemogram of two groups were detected before and after chemotherapy. RESULT After the treatment, the white blood cell counts of the two groups were significantly different (P < 0.05), but there was no statistical significance in qualitative comparison. Before and after the treatment, the difference of the white cell counts of the two groups detected had significant statistics (P < 0.05). The white cell counts of both groups declined after chemotherapy, but the treatment group decreased more significantly than the control group. Before and after the treatment, there were no statistical significances in quantitative and qualitative comparisons both in HGB and PLT. After the treatment, HGB and PLT contents of both groups declined, but there was no statistical difference between the two groups. CONCLUSION Compound granule prescription of thunberg fritillary bulb can relieve the bone marrow suppression in RAL patients caused by the chemotherapy, which is mainly reflected by the slowdown of reduction in white blood cells.