This article was aimed to study the ultrasonic extraction technology of total alkaloid in Mongolian medicine FLOS RHAPONTICI.UltravioletspectrophotometrywasusedtodeterminethecontentoftotalalkaloidinMongolian medicineFLOS RHAPONTICI,whichwastheevaluationindextoconfirmtheoptimaltechnologicalconditions.The results showed that the effecting order of 4 factors was ultrasonic power>solid-to-liquid ratio>ultrasonic temperature> ultrasonic time. The optimal condition was the ultrasonic temperature at 41°, ultrasonic power of 200 W, solid-to-liquid ratio at 1?28 g·mL-1, and the ultrasonic time of 40 min. The content of total alkaloid was 0.277 4%. It was concluded thattheextractiontechnologyanddeterminationmethodoftotalalkaloidinMongolianmedicineFLOS RHAPONTICIby response surface methodology (RSM) had the advantage of good stability and high predictability, which provided scientific and reasonable theory foundation for future study.

由于中药种类繁多,药材产地广,中药复方制剂由多种中药材组成,成分复杂,普通的分离方法效果差,而高效毛细管电泳兼有电泳和色谱技术的双重优势,具有高效、高速、高灵敏度、高自动化等特点,可进行区分真伪、产地及药材有效成分的分离等工作.高效毛细管电泳能对多种成分同时进行测定,已成为控制中药或天然药物质量最有效的手段之一.本文详细介绍了高效毛细管电泳技术在中药分析中的应用,为扩大其应用提供了理论参考.

依那普利是第二代长效血管紧张素Ⅱ转换酶抑制剂（ ACEI），已成为治疗高血压、心力衰竭、糖尿病及其并发症等疾病的重要药物。此类患者常伴有多个脏器病变，往往需要同时服用多种药物，增加了药物相互作用发生不良反应的几率。规范的联合用药可以利用药物的相互作用，产生叠加、协同作用，减少用药量及不良反应。本文对近年来依那普利治疗高血压、糖尿病肾病、心力衰竭过程中，与其他常用药物联合应用的文献进行综述，总结联合用药对临床效果的影响。