Objective To analyze the application of calcium channel blockers in patients of coronary heart disease in Peking Fuwai Hos-pital, to provide evidence for clinical rational use. Methods By extracting 146 coronary heart disease patients treated in Peking Fuwai Hospital, the situation of drug use were recorded and investigated. Results The utilization ratio of calcium channel blockers in coronary heart disease in hospital is 42. 47%, which is lower than other secondary prevention drugs in the same row. The influencing factors in-clude complication of cardiac failure or old myocardial infarction. Diltiazem and amlodipine have higher usage rate. Conclusion The ap-plication of calcium channel blockers in Peking Fuwai Hospital is basically rational, but the indications of calcium channel blockers are not explicit and the adverse effects are excessively scrupled in some patients, which need strengthening the training for clinicians to reasonable use of calcium channel blockers.
Berberine is an isoquinoline alkaloid isolated fromCoptis chinensis, and it is applied widely in clinic as a traditional anti-inflammatory and antibacterial drug for a long time. In recent years, it has been discovered that berberine still has lipid-regulating effects. Berberine plays the role of lipid-regulating by adjusting the structure of intestinal flora, influencing the synthesis and metabolism of bile acid, up-regulating the expression of low density lipoprotein receptor (LDLR), activating the expression of visceral adipose tissue related genes, elevating the expression of adiponectin, activating AMP-activated protein kinase (AMPK) pathways, and improving insulin resistance. This paper mainly summarizes the lipid-regulating function of berberine and its mechanisms of action.
目的 原发性高血压是常见的心血管疾病之一,但其发病机制尚未完全阐明.高血压是心脑血管疾病的独立危险因素,对高血压的有效管理可以降低心、脑血管事件的发生率.尽管目前可供选择的降压药物有多种,仍有部分难治性高血压患者当使用≥3种不同机制的足量降压药物,且其中至少有一种为利尿剂,血压控制仍不达标.研究表明焦虑、抑郁可能是此类患者血压难以控制的关键因素.在降压治疗基础上联合抗焦虑、抗抑郁治疗,可达到事半功倍的效果[1].近年来,焦虑、抑郁与高血压的关系已引起广泛关注,高血压可诱发焦虑、抑郁,而焦虑抑郁也会促发并加重高血压,使原有的降压药物疗效欠佳,形成难治性高血压.本文主要对高血压伴焦虑和抑郁的研究进展做一综述,为临床诊治提供参考.
