Objective To explore the protective mechanism of Danggui Sini Decoction on diabetic peripheral neuropathy (DPN) by observing the changes of NF-κb signaling pathway.Methods Forty-eight DPN rats were randomly divided into blank group, high-dose Danggui Sini Decoction group, low-dose Danggui Sini Decoction group and metformin group with 12 rats in each group after intraperitoneal injection of streptozotocin (STZ).To observe the effects of Danggui Sini Decoction on blood glucose, sciatic nerve conduction velocity, NF-κb protein and mRNA in diabetic rats.Results Compared with the model group, the Danggui Sini Decoction group could significantly reduce the blood glucose content, increase the conduction velocity of sciatic nerve, and inhibit the development of DPN by decreasing the expression levels of NF-κb protein and mRNA.Conclusion Danggui Sini Decoction has protective effect on sciatic nerve function in DPN rats.The mechanism may be related to the anti-inflammatory effect of Danggui Sini Decoction on decreasing NF-κb signal.

糖尿病属于中医"消渴"范畴,其病因复杂多样.张文风教授认为,糖尿病以阴虚燥热为病机关键,中焦气虚失运为基本病因,血行瘀滞贯穿疾病始终,虚为本,瘀为标.临床选用补阳还五汤作为主方,补虚祛瘀,取得了一定的临床疗效.

目的 观察当归四逆汤对糖尿病大鼠坐骨神经传导速度的影响及糖基化终末产物(AGEs)和AGEs受体(RAGE)的调节作用.方法 采用链脲佐菌素(STZ)复制糖尿病大鼠模型,模型鼠随机分为中药组、西药组、模型组,另设健康鼠为正常组.分别干预8 w后,检测糖尿病大鼠坐骨神经传导速度、坐骨神经病理形态、AGEs含量、RAGE mRNA表达水平.结果 与模型组相比,中药能够保护坐骨神经结构,显著降低AGEs含量、下调RAGE mRNA水平(P<0.05).结论 当归四逆汤能够通过下调AGEs/RAGE含量提高坐骨神经传导速度、保护坐骨神经结构,进而抑制大鼠糖尿病周围神经病变(DPN)的发生发展.