目的 通过Meta分析评价环孢素A治疗复发性流产的有效性和安全性.方法 检索中国知网、维普、万方、PubMed、Cochrane、Embase数据库,收集有关环孢素A治疗复发性流产的随机对照实验(RCT),检索时限为建库至2020年10月.根据纳入标准和排除标准筛选文献、提取数据并评价纳入研究的偏倚风险,通过RevMan 5.3软件进行Meta分析,评估Meta分析结果.结果 ①共纳入6篇文献,包括532名复发性流产患者.②环孢素A组与对照组的妊娠成功率相对危险度(RR)为1.24,95％CI为(1.13,1.37),具有统计学差异(P<0.001).③环孢素A组与常规治疗组妊娠期高血压发生率RR=0.22,95％CI为(0.08,0.63),差异有统计学意义(P=0.005).结论 Meta分析结果显示,环孢素A可提高妊娠成功率,并减少妊娠期高血压的发生,提示其可用于治疗复发性流产.但由于纳入文献数量有限,且样本量小,仍需进行大样本、高质量的研究进一步指导临床实践.

目的 分析2009-2018年甘肃省永靖县5岁以下儿童死亡状况,为做好儿童保健工作提供科学依据.方法 收集2009-2018年永靖县全部《围生儿、儿童死亡报告卡》,使用Epidata 3.0建立数据库,录入信息,采用SPSS 20.0软件分析.结果 新生儿、婴儿及5岁以下儿童死亡率均呈降低趋势(x2 =46.068,P＜0.01;x2=37.762,P＜0.01;x2 =45.124,P＜0.01),平均死亡率为5.90‰,8.55‰,9.79‰,其中新生儿死亡占5岁以下儿童死亡的60.28％.近十年造成永靖县5岁以下儿童死亡的死因中,前五位死因依次为出生窒息、早产/低体质量、先天性心脏病、其他出生缺陷及肺炎.2009-2018年婴儿死亡中,出生窒息及早产/低体质量的死亡率呈降低趋势(x2=12.003,P＜0.01;x2=10.862,P＜0.01).结论 2009-2018年,永靖县新生儿、婴儿及5岁以下儿童死亡率显著降低,且已低于全国水平.出生窒息、早产/低体质量、先天性心脏病、其他出生缺陷及肺炎是永靖县5岁以下儿童的主要死因.婴儿死亡中,出生窒息及早产/低体质量的死亡率明显降低.

介绍实施预检分诊管理办法,应对突发新型冠状病毒肺炎疫情,建立应急指挥系统,健全管理机制,总结控制实践措施,预防传播疫情.为进一步阻断疫情扩散,为同陷于新冠肺炎之灾的卫生机构提供经验参考.

Objective To explore the influencing factors of abnormal results in term of urine experimental detection indexes among 0-6 years old children,to provide the basis for prevention and treatment of chronic kidney diseases.Methods Children who provided urine samples were sampled by cluster sampling from 10 childcare facilities in Chenguan district in Lanzhou city in 2014.The association were analyzed among Urinalysis,physical examination and questionnaire survey were conducted,the effects of children' own physics,diet,environmental exposure factors,and disease histories of parents on abnormal situation of urine.Results 1 019 Urine samples were tested,which came from 582 boys(57.11％)and 437 girls(42.89％),the first five abnormal results of urinalysis included positive urine vitamin C 421 cases (41.32％),75 cases (7.36％) of positive urine leucocyte,67 cases (6.58％) of positive urobilinogen,61 cases (5.99％) of,positive urine ketonebod 56 cases (5.50％) of hematuria.The results of multivariable logistic regression analysis indicated that the intake of leaded food resulted in an increased positive rate of hematuria (OR=5.04,95％CI=1.26-20.25),the positive rate of urine leucocyte of boys is lower than that of girls(OR =0.10,CI=0.05-0.22);positive rate of urine vitamin C was lower in ＜1 years old group than that in 4-6 years old group (OR=0.16,95％CI=0.06-0.42),positive rate of urine vitamin C was lower in 2-3years old group than that in 4-6 years old group(OR=0.70,95％CI=0.54-0.91),positive rate of urine vitamin C of children whose parents were with some kidney disease was higher than children whose parents were without any kidney disease(OR=2.50,95％CI=1.58-3.97),positive rate of urine ketone body was higher in boys than that in girls (OR=2.72,95％CI=1.40-5.29),the higher positive rate of urine ketone body is associated with the higher BMI (OR =1.09,95％CI=1.01-1.17).No influential factors were found for the positive rate of urobilinogen.Conclusion The physical condition,diet and family history of kidney disease of children will lead to the abnormal urine.Children should try to avoid leaded food intake,susceptibility of urinary system of girls should be paid more attention to,reasonable intake of nutrients and appropriate weight should be advocated,actively screening urine should be conducted among children with family history of kidney disease especially.

OBJECTIVE:To study the clinical and molecular epidemiology characteristics of human Bocavirus 1-3 (HBoV1-3) in children for acute respiratory infection in Lanzhou area.METHODS:Nasopharyngeal aspiration samples and throat swabs were collected from 524 children with ARTI at the First Hospital of Lanzhou University, Gansu Province, China, between December 2009 and November 2010. Nested PCR was employed to screening HBoV1-3, which amplified a 518-bp fragment of the partial NS1 gene. Furthermore, a standard reverse transcription-PCR was used to screen for other common respiratory viruses.RESULTS:The overall frequency of HBoV was 8.2% (43/524), lining up behind human rhinovirus, RSV, parainfluenza virus 3. Thirty of the HBoV-postive children(69.8%) were co-infected with other respiratory viruses. The prevalence of HBoV1 in ALRTI was obviously higher than that in AURI. The 2 HBoV2 NS1 sequences shared 99% and 100% nucleotide sequence identity with HBoV2 strain CU47TH respectively. Two cases of HBoV2 postive children appears gastrointestinal symptoms. The one HBoV3 NS1 sequences shared 99% nucleotide sequence identity with HBoV3 isolate 46-BJ07.CONCLUSION:The HBoV3 was detected at the first time in lanzhou area. HBoV1-3 infection exists in children with acute respiratory tract infections in Lanzhou region, HBoV1 were dominant. The mixed infection rate was higher.