目的 观察腹腔镜手术联合热灌注配合自拟消瘤汤治疗进展期消化道肿瘤的效果.方法 将102例进展期消化道肿瘤患者随机分为2组,对照组51例给予腹腔镜手术联合热灌注治疗,观察组51例在对照组治疗基础上加用自拟消瘤汤,观察2组治疗效果、不良反应发生情况及治疗前后NK、CD4+/CD8+水平.结果 治疗后观察组总有效率明显高于对照组(P<0.05),各项不良反应发生率和Ⅲ级以上的不良反应总发生率均显著低于对照组(P均<0.05);NK及CD4+/CD8+水平明显高于对照组(P均<0.05).结论 腹腔镜手术联合热灌注配合自拟消瘤汤治疗进展期消化道肿瘤能明显提高治疗效果,减少不良反应,改善患者免疫状态.

目的：探讨溃疡性结肠炎（ UC）患者的骨密度变化情况。方法选取我院2012年1月－2014年12月收治的UC患者100例作为观察组，健康体检者60例作为对照组。超声检测2组L1～L4骨密度（ BMD）。结果观察组患者骨密度降低56例（56％），骨量减少37例（37％），骨质疏松7例（7％）。观察组患者的骨密度及T值均低于对照组，差异均有统计学意义（P＜0．05）。结论 UC患者可引起BMD降低而发生骨质疏松。

目的：探讨溃疡性结肠炎（UC）患者血清肿瘤坏死因子（TNF-α）、白细胞介素-6（IL-6）及白细胞介素-8（IL-8）水平与骨质疏松的相关性。方法选取该院2012年1月－2014年12月收治的UC患者100例作为观察组，健康体检者60例作为对照组。采用酶联免疫吸附试验（ ELISA法）检测2组血清TNF-α、IL-6及IL-8水平，超声检测2组L1～L4骨密度（BMD）。结果观察组患者骨密度降低47例（47％），骨密度低于对照组，血清TNF-α、IL-6及IL-8水平高于对照组，差异均有统计学意义（P＜0．05）。结论血清TNF-α、IL-6及IL-8水平在UC患者骨质疏松发生中起重要作用，检测UC患者血清TNF-α、IL-6及IL-8水平可用于诊断和预防骨质疏松。

Objective To investigate the clinical effect of Qihuang Tongmi Soft Capsules in treatment of functional constipation. Methods The patients with functional constipation (284 cases) of research centers from October 2013 to March 2014 were randomly divided into control (145 cases) and treatment (139 cases) groups. The patients in the control group were po administered with Maren Soft Capsules 30 min after meals, 1 grain/time, twice daily. The patients in the treatment group were po administered with Qihuang Tongmi Soft Capsules 30 min after meals, 3 grains/time, twice daily. The patients in two groups were treated for 3 weeks. After treatment, the efficacies in two groups were evaluated, while the treatment safety of Qihuang Tongmi Soft Capsules was assessed. Results After treatment, the markedly effective rate and efficacy in the control group was 50.3% and 84.8%, respectively, while those in the treatment group were 59.7%and 96.4%, respectively. The markedly effective rate and efficacy in the treatment group was higher than those in the control group, and there were differences between two groups (P<0.05, 0.01). The markedly effective rate of stool character, stool frequency, bowel obstruction symptom, and the efficacy of endless defecate feeling and sense of defecation/obstruction during defecation in the treatment group were significantly higher than those in the control group (P<0.05, 0.01). For the treatment of deficiency constipation, the markedly effective rate and efficacies in the control group were 52.4%and 86.9%, respectively, while those in the treatment group were 57.6%and 94.2%, respectively. The markedly effective rate and efficacies in the treatment group were higher than those in the control group, and there were differences between the two groups (P<0.05, 0.01). The markedly effective rate of breathe shortness, and dizziness, and the efficacies of breath shortness, pale tongue moss thin, and pulse weakness in the treatment group were significantly higher than those in the control group (P<0.05, 0.01). There were no adverse reactions in two groups. Conclusion Qihuang Tongmi Soft Capsules has good clinical effect in treatment of functional constipation, and no adverse reaction occurred, which is worth clinical promotion.