Objective To analyze the clinical features and CT imaging findings of85 patients with drug-induced liver injury (DILI) to provide references for clinical prevention, diagnosis and treatment. Methods A total of 85 patients with DILI diagnosed in the hospital from January 2010 to July 2018 were included in the study. Gender, age, medical history, medication history, clinical features, clinical classification, biochemical indicators of liver function and CT findings were analyzed retrospectively. Results The ratio of male to female in this study was 1:1.18, and most patients were between 41 and60 years old, accounting for 73.75％. The most common clinical manifestations included poor appetite, fatigue, upper abdominal discomfort and loss of appetite. Among the patients with DILI, the proportion of three or more combinedmedication was the highest, followed by traditional Chinese medicines, antibiotics, antiviral drugs and non-steroidal anti-inflammatory drugs. The main clinical type of DILI was hepatocyte type, followed by cholestasis typeand the mixed type. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in hepatocytetype and mixed type were significantly higher than those in cholestasis type (P＜0.05), but there was no significant difference in the level of glutamyl transferase (GGT) among the three types (P＞0.05). CT showed that main types of DILI were diffuse liver injury and focal liver injury, accounting for 52.94％and 43.53％, respectively. Multifocal liver injury was rare, accounting for only 3.53％.The CT number of the them were 31～42 Hu, 41～49 Hu and 45～51 Hu, respectively. CT showed decreased liver parenchyma density, multiple small patchy low-density lesions and multifocal low-density patchy shadow. Conclusion DILI occur in all ages, and the clinical manifestations are not specific. The drugs causing DILI are various. Therefore, clinical use of drugs should focus on medication safety when treating diseases. The main clinical type of DILI is hepatocyte injury, and the CT image is characteristic, which is of certain reference value for clinical diagnosis.
目的:分析研讨骨髓细胞形态学诊断不明原因发热(FUO)的临床价值.方法:随机从解放军第152中心医院2012年3月至2017年10月收治的经病理科确诊的FUO的患者中抽取100例纳入到讨论中,患者均接受实验室常规检查和骨髓细胞形态学检查,本研究以病理检查的诊断结果为准,将检查结果与病理科结果进行比较.结秉:实验室检查的准确率为25.00％,低于骨髓细胞形态学检查的95.00％,差异具有统计学意义(P＜0.05);骨髓细胞形态学检查的准确率与病理检查比较,差异无统计学意义(P＞0.05).结论:临床采用骨髓细胞形态的方法诊断FUO的诊断准确率高,该方法可为临床诊治FUO提供一定依据.
目的 研究分析甲状腺不同类型结节钙化采用彩色多普勒超声进行良恶性鉴别的临床价值,为甲状腺结节的临床诊断方法提供参考.方法 采用回顾性病例对照分析方法,选取甲状腺结节患者262例,结节均以实性或囊性为主,合并不同程度类型钙化灶.所有患者住院期间均接受手术治疗,术前接受彩色多普勒超声检查,评估结节的超声声像特征,并依据钙化类型、结节大小、内部回声以及血管模式、血供程度分别对患者进行分组,结合术后病理学检查结果,组间比较彩色多普勒超声在甲状腺不同类型钙化结节良恶性诊断中的价值.结果 262例甲状腺结节中,经术后病理学证实良性结节201例(76.7%),其中微钙化24例,环状钙化19例,粗钙化158例;恶性结节61例(23.3%),包括甲状腺乳头状癌53例,髓样癌4例,滤泡状癌4例,其中微钙化56例,环状钙化3例,粗钙化2例.262例甲状腺结节中均以混合血管型为主,其中恶性结节主要为低血供,良性结节主要为高血供,但良性结节在≤1 cm时以低血供为主.依据内部回声,中等/高回声组在良性结节中构成比较高,而恶性结节在极低/低回声组中构成比较高.结论 依据甲状腺不同类型钙化结节的钙化类型及其他超声指标,可有助于鉴别良恶性疾病.
