目的:观察中药阴道冲洗治疗放射性阴道炎的临床疗效.方法:选取2016年2月-2018年8月于甘肃省肿瘤医院行根治性放射治疗的宫颈癌患者300例,按随机数字表法分为观察组(中药煎剂冲洗组)和对照组Ⅰ(1/90洁尔阴洗液冲洗组),对照组Ⅱ(1/5000～8000)高锰酸钾溶液冲洗组),各100例.观察比较三组防治放射性阴道炎的临床疗效.结果:观察组治愈率、总有效率均高于对照组Ⅰ、对照组Ⅱ,差异有统计学意义(P<0.05).结论:中药汤剂阴道冲洗治疗放射性阴道炎疗效显著,值得推广应用.

目的:探讨注射聚乙二醇重组人粒细胞集落刺激因子(PEG-rhG-CSF)治疗宫颈癌化疗所致中性粒细胞减少症的有效性和安全性.方法:筛选2016年1月-2018年12月来甘肃省肿瘤医院进行宫颈癌治疗的女性患者162例,随机分成对照组和治疗组.对照组79例,平均年龄为(38.7±3.6)岁;治疗组83例,平均年龄为(41.2±4.3岁).2组皆进行同步放化疗,对照组患者化疗24 h注射重组人粒细胞集落刺激因子(rhG-CSF),治疗组患者化疗24 h后注射聚乙二醇重组人粒细胞集落刺激因子(PEG-rhG-CSF);2组患者化疗后定期复查血常规,检查骨髓抑制差异、中性粒细胞绝对值随时间变化差异、化疗延迟率及不良反应发生率.结果:治疗组给药后12～144 h中性粒细胞数与增殖率,化疗第一周期中性粒细胞数减少、白细胞减少方面均有显著差异(P＜0.05);治疗组中性粒细胞数绝对值在不同时间点高于对照组,在给药第5、10天有显著性差异(P＜0.05);另外治疗组的化疗延迟人数少于对照组(P＜0.05);2组不良反应无显著差异(P＞0.05).结论:PEG-rhG-CSF在治疗宫颈癌同步放化疗中有较好的疗效和安全性.

放射性黏膜损伤已成为头颈部肿瘤放疗常见的并发症,且对于患者预后及治疗影响较大,成为影响头颈部肿瘤患者放疗成败的重要因素.本文就头颈部肿瘤放疗过程中腮腺功能损伤与放射性口腔黏膜损伤进行归纳总结.

Idiopathic thrombocytopenic purpura( ITP)was characterized by repeated bruises,scat-tered bleeder in the mucous membrane of skin and was prolonged unhealed. Glucocorticoid was the first choice in treating this disease according to Western medicine therapy. However,the clinical effect of Glu-cocorticoid was not satisfying due to its severe side effects and numerous complications,as well as drug de-pendency,which cause the disease relapse after the drug was stopped. After 50 years of clinical practice of Chi-nese medicine for the treatment of the disease,Professor PEI Zheng-xue has accumulated rich experience. The clinical effect is remarkable. According to the different etiology and pathogenesis,he chooses different tradition-al Chinese medicine syndrome. And adopt unique treatment methods with heat-clearing and detoxifying,which will promote blood circulation to remove blood stasis,strengthen and consolidate body resistance.

The theory of TCM viscera is the basis of TCM theory as well as an important part of TCM. Heart, liver, spleen, lungs and kidneys in TCM share similarity with that of the western medicine while they also are rich in difference, therefore, TCM learners should be aware of the difference and correlations between the TCM viscera and organs identified in western medicine, which would help to develop traditional Chinese medicine and modernize TCM to achieve the advancement of TCM with modern science and technology.

裴正学教授以“西医诊断,中医辨证,中药为主,西药为辅”十六字方针为原则,采用中医辨证论治的方法,治疗银屑病取得较好的疗效.在治疗过程中分三型辨证论治,以“克银一号、克银二号方”和“三味消土方”为主加减化裁,配合抗生素消炎退热,临床疗效显著.本文从银屑病的典型病案人手,从病因病机、辨证论治以及临床实践方面,探讨治疗银屑病的临床经验.

In accordance with clinical practice for thousands of years and different effects, prescriptions of TCM have developed different systems. The system included Han, Tu, Xia, He, Qing, Wen, Bu, and divided into the Mahuang Guizhi prescriptions, the Daxiao Chaihe prescriptions, the Baihu Chengqi prescriptions, the Sijun Siwu prescriptions, the Liuwei Bawei prescriptions, the Sangjue Yinqiao prescriptions. Each prescription was complexly adapted for good efficacy in clinic by adding and subtracting .

The guideline“The integrative medicine syndrome differentiation,TCM mainly used and western medicine supplemented by”for diseases diagnosis and treatment was summarized;Professor Pei’s Academic Ideology and clinical experience on hepatic carcinoma benefited to etiology and pathogenesis,syndrome differentiation,and clinical experience through inhibitting tumor recurrence and metastasis could improve clinical symptoms,enhance immunity.

Early 2000 years ago,a deeper understanding of human diseases was coming into TCM,Chinese medicine.A TCM classic book saying: "righteousness deposit inside,evil can not do",meaning that as long as the existence of the body righteousness,pathogen would not violate the body caused by disease onset; also saying: "evil inside,the righteousness become empty".Therefore,TCM medicine will call righteousness as Guben.500 years ago,with the rise of Western medicine,the human body was found a defensive function,this function is performed by specific immunity and nonspecific immunity of two factors,namely the so-called modern medicine immune system.With nearly 30 years of advances in Western medicine,immunology has also been considerablly developed; At the very begining of diseases understanding,Chinese and Western medicine seems to have consensus.

目的:研究裴氏升血颗粒合TP-5对荷H22(肝癌)瘤小鼠免疫功能的影响.方法:本研究拟采用裴氏升血颗粒、裴氏升血颗粒与胸腺五肽联合、胸腺五肽分别对荷H22(肝癌)瘤小鼠进行干预,而后通过对小鼠抑瘤率、胸腺指数、脾脏指数、脾淋巴细胞增值能力、血清IL-2、IL-4水平进行检测及数据处理,了解药物干预后荷H22(肝癌)瘤小鼠的免疫器官状态及免疫功能变化.结果:PSXKL组、PSXKL+TP-5组荷瘤小鼠的结束体重、平均瘤重、抑瘤率、胸腺指数(TI)、脾脏指数(SI)均与模型组有显著差异;TP-5组的胸腺指数(TI)、脾脏指数(SI)均与模型组有显著差异.而PSXKL组、PSXKL+TP-5组荷瘤小鼠的结束体重与TP-5组相比有显著差异.PSXKL+TP-5组和TP-5组荷瘤小鼠的血清IL-2和IL-4含量、脾B淋巴细胞增殖率(％)(以LPS为刺激因子)、脾T淋巴细胞增殖率(％)(以ConA为刺激因子)均与模型组有显著差异.结论:TP-5对荷瘤小鼠免疫器官有明显影响,而对荷瘤小鼠的全身状况无明显改善,使荷瘤小鼠细胞免疫功能增强,对荷瘤小鼠脾T淋巴细胞增殖功能有积极影响.裴氏升血颗粒及其与TP-5联合后均对荷瘤小鼠的全身状况有明显改善,同时对其免疫器官也有明显的影响,使之趋于正常;使荷瘤小鼠细胞免疫功能增强,同时对荷瘤小鼠脾T淋巴细胞、B淋巴细胞增殖功能有积极影响.

<正>进入21世纪,癌症已经成为危害人类身体健康的第一杀手,并成为全球最大的公共卫生问题之一。据WHO报告[1],2000年全球新发癌症病人达1 010万,死亡620万。

在系统论指导下,利用多学科技术研究中西医学理论实质及其内在联系,更有利于促进中西医学找到共同语言。作者根据已发表的有关中药复方抗癫痫效应现代医学研究文献为基础,分析中药特征与抗癫痫效应的关系并建立相应的数学模型。收集、筛选1980年以来国内公开发表的2005年版《中国药典》所载中药复方抗癫痫研究的文献,根据检索结果统计不同传统功能分类、不同药性、药味、归经的中药数量和其中具有抗癫痫效应的中药味数;用多元判别分析建立回归数学模型。结果表明在这50味中药中,平肝熄风药的抗癫痫效应研究比较活跃,具有抗癫痫效应的比例为61.11%,归经分类分析,归胆经、心经、肾经的比例最多,与合计率比较,均在统计学上具有显著性差异(P<0.05)。采用逐步的Logistic回归筛选主要的影响因素,结果表明归心、脾、胆、心包经以及安神药、平肝熄风药、解表药、化痰止咳药及补虚药均是具有抗癫痫效应的重要影响因素(回归系数>0,且P<0.01)。这也与中医学有关理论相吻合。多元判别分析预测结果与原判定结果总符合率为91.6%。中药的传统功能分类、药性、归经与抗癫痫效应关系密切,以此为基础建立的数学模型可以作为中药抗癫痫效应研究及临床用药的参考。