Objective:To analyze the curative effect of paclitaxel combined with carboplatin in the treatment of ovarian cancer and the effect on the serum carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199) and carcinoembryonic antigen (CEA) levels.Methods:41 cases of ovarian cancer patients admitted in our hospital from January 2014 to January 2016 were selected and divided into the control group (n=20) and the research group (n=21) according to random number table method.The control group was treated byh paclitaxel combined with cisplatin, and the research group was treated by paclitaxel combined with carboplatin.Then the curative effect, changes of serum levels of CA125, CA199 and CEA, karst scores before and after treatment, incidence of side effects and survival were compared between two groups.Results:After treatment, the total effective rate of research group was higher than that of the control group (P<0.05).The serum levels of CA125, CA199 and CEA of both groups were decreased than those before treatment, which were obviously lower in the research group than those of the control group (P<0.05).The karst score improvement rate of research group was higher than that of the control group (P<0.05), while the incidence rates of gastrointestinal reaction, neurotoxic injury, bone marrow inhibition and blood system toxicity in research group were lower than those in the control group (P<0.05).No significant difference was found in the 2-year survival rate and median survival time between two groups (P>0.05).Conclusion:Paclitaxel combined with carboplatin is more effective than paclitaxel combined with cisplatin in the treatment of ovarian cancer, it can effectively reduce the serum levels of CA125, CA199 and CEA, improve the quality of life of patients.

目的:探讨鸦胆子油乳对卵巢癌患者血清CA125、CA199及临床疗效的影响.方法:收集我院收治的卵巢癌患者18例,随机分为对照组和实验组,每组各9例,对照组患者采用PT化疗方案,具体采用紫杉醇和顺铂.实验组患者在此基础上给予鸦胆子油乳静脉滴注,20～30 mL/次,1次/d,化疗期间不间断应用.治疗连续8周.治疗结束后,对患者CEA、CA125、CA199以及临床疗效进行检测并比较.结果:与治疗前相比,治疗后患者的CEA、CA125、CA199水平均下降(P＜0.05);与对照组相比,实验组患者的CEA、CA125、CA199水平较低,临床治疗总有效率较高(P＜0.05).结论:鸦胆子油乳能够降低卵巢癌患者血清CEA、CA125、CA199水平,临床疗效较好,对临床有指导意义.

目的：：探讨GEMOX方案(吉西他滨联合奥沙利铂)治疗铂类耐药复发及难治性卵巢癌的疗效和不良反应。方法：我科自2008年10月至2013年10月应用吉西他滨联合奥沙利铂治疗复发、难治性上皮性卵巢癌患者20例，其中3例为难治性、17例为铂类耐药复发。所有患者均予吉西他滨1000mg/m2第1、8天静脉给药，奥沙利铂130mg/m2，第1天静脉给药。3周为1周期，每个患者至少接受2周期化疗用药。2个周期后评价疗效、疾病控制率，每周期均监测不良反应。结果：20例患者共完成96个化疗周期，有效率为40%(8/20)，疾病控制率为75%(15/20)；主要毒性反应为骨髓抑制、神经毒性和消化道反应。结论：GEMOX方案治疗铂类耐药复发、难治性上皮性卵巢癌疗效较好，毒性反应可以耐受。