Objective:To analyze the curative effect of paclitaxel combined with carboplatin in the treatment of ovarian cancer and the effect on the serum carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199) and carcinoembryonic antigen (CEA) levels.Methods:41 cases of ovarian cancer patients admitted in our hospital from January 2014 to January 2016 were selected and divided into the control group (n=20) and the research group (n=21) according to random number table method.The control group was treated byh paclitaxel combined with cisplatin, and the research group was treated by paclitaxel combined with carboplatin.Then the curative effect, changes of serum levels of CA125, CA199 and CEA, karst scores before and after treatment, incidence of side effects and survival were compared between two groups.Results:After treatment, the total effective rate of research group was higher than that of the control group (P<0.05).The serum levels of CA125, CA199 and CEA of both groups were decreased than those before treatment, which were obviously lower in the research group than those of the control group (P<0.05).The karst score improvement rate of research group was higher than that of the control group (P<0.05), while the incidence rates of gastrointestinal reaction, neurotoxic injury, bone marrow inhibition and blood system toxicity in research group were lower than those in the control group (P<0.05).No significant difference was found in the 2-year survival rate and median survival time between two groups (P>0.05).Conclusion:Paclitaxel combined with carboplatin is more effective than paclitaxel combined with cisplatin in the treatment of ovarian cancer, it can effectively reduce the serum levels of CA125, CA199 and CEA, improve the quality of life of patients.

目的:探讨鸦胆子油乳对卵巢癌患者血清CA125、CA199及临床疗效的影响.方法:收集我院收治的卵巢癌患者18例,随机分为对照组和实验组,每组各9例,对照组患者采用PT化疗方案,具体采用紫杉醇和顺铂.实验组患者在此基础上给予鸦胆子油乳静脉滴注,20～30 mL/次,1次/d,化疗期间不间断应用.治疗连续8周.治疗结束后,对患者CEA、CA125、CA199以及临床疗效进行检测并比较.结果:与治疗前相比,治疗后患者的CEA、CA125、CA199水平均下降(P＜0.05);与对照组相比,实验组患者的CEA、CA125、CA199水平较低,临床治疗总有效率较高(P＜0.05).结论:鸦胆子油乳能够降低卵巢癌患者血清CEA、CA125、CA199水平,临床疗效较好,对临床有指导意义.

目的：：探讨GEMOX方案(吉西他滨联合奥沙利铂)治疗铂类耐药复发及难治性卵巢癌的疗效和不良反应。方法：我科自2008年10月至2013年10月应用吉西他滨联合奥沙利铂治疗复发、难治性上皮性卵巢癌患者20例，其中3例为难治性、17例为铂类耐药复发。所有患者均予吉西他滨1000mg/m2第1、8天静脉给药，奥沙利铂130mg/m2，第1天静脉给药。3周为1周期，每个患者至少接受2周期化疗用药。2个周期后评价疗效、疾病控制率，每周期均监测不良反应。结果：20例患者共完成96个化疗周期，有效率为40%(8/20)，疾病控制率为75%(15/20)；主要毒性反应为骨髓抑制、神经毒性和消化道反应。结论：GEMOX方案治疗铂类耐药复发、难治性上皮性卵巢癌疗效较好，毒性反应可以耐受。

Objective:To evaluate the efficacy and side effects of chemotherapy with GDP regimen in patients with relapsed or refractory Non-Hodgkin's lymphoma. Methods: Twenty-three patients with relapsed or refractory non-Hodgkin's lymphoma were enrolled from January 2008 to March 2010. They received gemcitabine 1000mg/m2 ,d1,d8 and cisplatin 25mg/m2,d1-d3, in combination with dexamethasone 20-40mg d1-d3 every 21 days. Efficacy assessment was conducted after two cycles therapy. Results: Among 23 patients,5 cases achieved complete response (21.7%) and 9 cases achieved partial response (39.1%).The median time to progression (TTP) was 5 months (95%CI:3-8 months).The major adverse events were mild to moderate gastrointestinal reaction and myelosuppression which included 2 cases of grade 3-4 leukopenia and 1case of grade 4 thrombopenia with hemorrhage and 1 case of grade 3-4 hemophthisis. Conclusion: GDP regimen is effective and well-tolerated for relapsed or refractory non-Hodgkin's lymphoma.

Objective:To observe the effect and side effects of topotecan in combination with carboplatin in the treatment of recurrent small cell lung cancer.Methods:Twenty-nine patients of recurrent small cell lung cancer enrolled in the study.Topotecan was given at the dose of 1.2mg/m2 on d1-5 and carboplatin was administered at the dose of 300mg/m2 on d5 in a cycle of 21 days.The patients were evaluated at least after 2 cycles.Results:One patient got complete response and eleven patients got partial response.The overall response rate was 41.38%,and the response rates of sensitive group and refractory groups were 47.62% and 25% respectively.Conclusion:The regimen of topotecan and carboplatin shows better activity in retreated small cell lung cancer patients.The main toxicity is hematological toxicity and can be tolerated.

目的 观察周剂量紫杉醇(PTX)加顺铂(DDP)联合化疗治疗晚期食管癌的近期疗效和毒副反应.方法 晚期食管癌患者48例分为两组,PTX+DDP组:PTX 80mg/m2静滴第1,8天;顺铂20mg/d静滴第1～5天.5-Fu+DDP+CF组:5-Fu 500mg/m2静滴,第1～5天;DDP 20mg/d静滴第1～5天,CF 100mg/次静滴,在5-Fu前2h内给药第1～5天,21天为1周期,2周期后按UICC标准评价近期疗效和毒副反应.结果 PTX+DDP方案治疗20例食管癌患者有效率为70%;5-Fu+DDP+CF方案治疗28例的有效率为50%.前一联合方案总有效率高于后者,有显著性差异(P＜0.05),不良反应也较后者重,但大多数患者能耐受,主要为剂量限制性毒性.表现为Ⅱ～Ⅲ度为主的骨髓抑制.结论 周剂量紫杉醇联合顺铂治疗晚期食管癌近期疗效显著,毒副反应小.

Objective:To observe analgesic effect and main side effects of Oxycodone Hydrochloride Controlled-release Tablets(Oxycontin)in management of the moderate and severe cancer pain.Methods:Sixty patients with cancer pain were randomly divided into Oxycontin group(30 cases)and MS-contin group(30 cases).Oxycontin was administered at an initial dose of 10 mg every 12h and titrated upwards according to the extent of pain relief.Results:In [KG(-*9]Oxycontin group effective rate was 96.1%.The quality of life was significantly improved after treatment(P0.01).The common side effects were constipation dizziness nausea,vomitiny,sedation.No serious side effect was found.Oxycontin didn't show obvious affection to the function of liver,kidney and blood pressure,heart rate.Conclusion:Oxycontin display a comparable or slightly superior efficiency MS-contin and works quickly,safely and can improve the quality of life for the treatment of patients with moderate to severe cancer pain.

卵巢上皮性癌为死亡率最高的妇科恶性肿瘤.多数病例确诊时已为晚期,理想的肿瘤细胞减灭术和静脉化疗配合腹腔内化疗等综合治疗可提高疗效,改善预后.

目的:观察分析周剂量紫杉醇（PTX）联合顺铂（DDP）方案治疗晚期食管癌的近期疗效和毒副反应。方法:29例Ⅲ、Ⅳ晚期食管癌患者,给予周剂量PTX+DDP,即PTX80mg/m2d1、d8,DDP40mgd1～d3,21d为1周期,2周期后按WHO标准评价疗效和毒副反应。结果:全组29例,均可评价疗效,总有效率55.2%,16例初治组有效率为62.5%,13例复治组有效率为46.2%。不良反应主要表现为白细胞减少、胃肠道反应和脱发。结论:周剂量紫杉醇联合顺铂治疗晚期食管癌的近期疗效较高,毒副反应轻,值得进一步观察应用。

目的:观察国产去甲长春花碱（NVB）加顺铂（DDP）联合治疗晚期非小细胞肺癌的疗效。方法:符合入选条件的ⅢB-Ⅳ期NSCLC患者48例,治疗方案NVB25mg/m2,ivdl,8,DDP20mg/m2,ivd1-5,21天为一周期,每3周重复一次,每例至少用2个周期。结果:PR20例,SD20例,PD8例,有效率44%,中位生存期10个月。主要毒副反应为骨髓抑制,轻度的胃肠道反应及少数局部静脉炎。结论:国产去甲长春碱加顺铂联合化疗治疗晚期非小细胞肺癌疗效明显,毒副反应可耐受。