Isolated cortical vein thrombosis (ICoVT) is very rare and its clinical symptoms lack specificity.Unlike cerebral venous sinus thrombosis,ICoVT rarely presents increased intracranial pressure and optic disc edema.Imaging examination,especially MRI examination,is very important for the diagnosis of this disease.T2 *-weighted gradient echo sequence and susceptibility-weighted imaging contribute to the early diagnosis of the disease.This article reviews the clinical symptoms,diagnosis,and treatment of ICoVT.

Objective To investigate the clinical characteristics of anti-leucine-rich glioma-inactivated 1 (LGI1) antibody-associated encephalitis. Methods and Results From June 2016 to October 2017, a total of 7 patients with anti-LGI1 antibody-associated limbic encephalitis were diagnosed and treated, with an average age at onset (48.29 ± 15.09) years. Patients presented acute (4 cases) or subacute onset (3 cases), with seizures and memory dysfunction as the main manifestations. It may be accompanied by faciobrachial dystonic seizures (FBDS, 5 cases), mental and behavioral abnormalities or personality changes (4 cases), or even combined with intractable hyponatremia (2 cases) or thymoma (one case). Serum anti-LGI1 antibody tests showed positive results in 7 cases, and cerebrospinal fluid (CSF) anti-LGI1 antibody tests showed positive results in 6 cases. MRI showed unilateral or bilateral medial temporal lobe abnormal signals (6 cases), and EEG showed continuous spike-slow waves or slow waves (one case). High-dose glucocorticoid sequential therapy was effective in 6 cases. During the follow-up period, 2 cases were lost, and the other 5 cases presented long-term memory disorder (3 cases) or long-term and short-term memory disorders (2 cases). Among them, one case relapsed 6 months after discharge. Conclusions According to specific clinical manifestations of patients (such as onset of FBDS, memory disorders, etc.), combined with imaging and CSF examination results, this disease can be clearly diagnosed. Immunosuppressive agents can effectively improve the clinical symptoms and prognosis. DOI: 10.3969/j.issn.1672-6731.2019.04.010

肿瘤患者由于高凝状态, 易发生血栓和栓塞.Trousseau 综合征是指肿瘤患者反复发生的不明原因的动脉或静脉血栓栓塞事件,目前已成为肿瘤患者的第二位死因,仅次于肿瘤本身.本文报道1例罕见的全身多处动、静脉血栓栓塞(急性多发性脑梗死,双下肢深静脉血栓形成、肾脏多发性梗死、脾脏多发性梗死、急性心肌梗死)的肺癌合并Trousseau综合征病例.

各类维生素在机体生长发育中具有重要作用,维生素缺乏常导致多种疾病发生,而维生素摄入过量也会危害健康.近年来许多研究发现,维生素与高血压等心血管疾病的发生密切相关,越来越多的实验和临床观察结果证实补充维生素可对血压产生一定影响,对高血压及其并发症的防治具有积极作用.该文对近年来国内外有关维生素水平和血压关系的研究,以及补充维生素对高血压及其并发症疗效的影响研究进行综述,为高血压防治策略的新方向、新思路提供理论依据.