In order to comprehensively explore multitarget mechanism and key active compounds of Artemisia argyi essential oil (AAEO) in the treatment of pressure injuries (PIs), we analyzed the biological functions and pathways involved in the intersection targets of AAEO and PIs based on network pharmacology, and the affinity of AAEO active compounds and core targets was verified by molecular docking finally. In our study, we first screened 54 effective components according to the relative content and biological activity. In total, 103 targets related to active compounds of AAEO and 2760 targets associated with PIs were obtained, respectively, and 50 key targets were overlapped by Venny 2.1.0. The construction of key targets-compounds network was achieved by the STRING database and Cytoscape 3.7.2 software. GO analysis from Matespace shows that GO results are mainly enriched in biological processes, including adrenergic receptor activity, neurotransmitter clearance, and neurotransmitter metabolic process. KEGG analysis by the David and Kobas website shows that the key targets can achieve the treatment on PIs through a pathway in cancer, PI3K-Akt signaling pathway, human immunodeficiency virus 1 infection, MAPK signaling pathway, Wnt signaling pathway, etc. In addition, molecular docking results from the CB-Dock server indicated that active compounds of AAEO had good activity docking with the first 10 key targets. In conclusion, the potential targets and regulatory molecular mechanisms of AAEO in the treatment of PIs were analyzed by network pharmacology and molecular docking. AAEO can cure PIs through the synergistic effect of multicomponent, multitarget, and multipathway, providing a theoretical basis and new direction for further study.

目的:了解养老护理员实习生中开设叙事教育课程的效果.方法:选取2019年7月—2020年6月于某养老机构实习的82名养老护理员,随机分为观察组和对照组,每组41人.对照组采用传统学习与带教方式,观察组在对照组基础上接受叙事教育课程.分别在课程开始前、课程结束时、课程结束5个月后的3个时间点进行课程评价与反馈.结果:在课程结束时及课程结束5个月后,观察组杰弗逊共情能力量表(JSE?HP)评分与人文关怀能力量表(CAI)评分均高于对照组,差异具有统计学意义(P<0.01),观察组养老护理员认为开设叙事教育课程提高了察觉老人情绪和解决问题的能力,具有现实意义.在课程结束5个月后,观察组JSE?HP、CAI评分较课程结束时略有降低,叙事写作坚持率由70.73％降为7.32％.结论:叙事教育课程能够提升养老护理员的人文素养,对于养老护理员适应工作岗位具有指导作用,但应作为基础课程长期开展.

目的 分析我国出院准备度的研究现况、热点及前沿,为出院准备相关工作及研究方向提供依据.方法 以中国知网(CNKI)为检索源,以"出院准备度""出院准备""出院计划"为检索词,检索1982年1月1日—2020年12月31日相关文献,应用CiteSpace V5.6.R5软件进行可视化分析.结果 共纳入相关文献820篇.年发文量呈逐年上升趋势.发文机构和作者分布均较为分散,且相互合作不紧密.研究热点有出院计划、影响因素、护理和出院准备服务等,研究前沿为延续护理和脑卒中.结论 出院准备度日益受到关注,研究机构、作者间需加强合作,不断拓展研究内容的广度和深度.

目的 探讨银离子敷料联合负压引流治疗感染性伤口的有效性.方法 检索Cochrane Library、PubMed、Embase、Web of Science、中国生物医学文献服务系统、中国知网、万方数据平台、维普中文期刊服务平台等数据库中关于银离子敷料联合负压引流治疗感染性伤口的随机对照研究,由2名研究人员进行资料提取和文献质量评价,并使用RevMan 5.4软件进行Meta分析.结果 共纳入9篇文献,总样本量为690例,其中试验组采用银离子敷料联合负压引流疗法,对照组采用银离子敷料、负压引流疗法或常规换药中一种方式进行治疗.Meta分析结果:试验组能降低压疮愈合计分量表评分[MD=-1.44,95％CI(-2.49,-0.39),Z=2.70,P=0.007]、细菌阳性率[OR=0.37,95％CI(0.27,0.50),Z=6.16,P<0.001],缩短伤口愈合时间[MD=-6.70,95％CI(-9.00,-4.40),Z=5.71,P<0.001],提高伤口痊愈率[OR=3.32,95％CI(1.72,6.40),Z=3.58,P<0.001].结论 银离子敷料联合负压引流治疗能有效促进感染性伤口的愈合.

背景:富血小板血浆与负压引流疗法已被广泛应用于各种慢性创面的治疗,并取得了良好的临床效果,但两者联合应用于慢性难愈性创面的效果尚缺乏来自随机对照研究的证据.目的:评价富血小板血浆联合负压引流疗法治疗慢性难愈性创面的效果.方法:使用计算机对国内外数据库(CNKI、维普网、万方数据库、SinoMed、Web of Science、PubMed、EMbase等)进行检索,检索范围从建库至2019年6月,所有关于富血小板血浆联合负压引流疗法治疗慢性难愈性创面效果的随机对照试验,对纳入研究的文献采用Cochrane系统评价方法进行评价,采用Review manager 5.3软件进行Meta分析,分析的结局指标包括创面愈合率、创面愈合时间、住院时间、疼痛评分、细菌阳性率.结果 与结论:①共纳入1 1篇随机对照试验,包括743例慢性创面患者,观察组均采用富血小板血浆联合负压引流疗法进行干预,对照组采用常规换药或者单纯负压引流疗法进行干预;②Meta分析显示与对照组比较,观察组创面愈合率升高[RR=2.19,95％CI(1.82,2.62),P＜0.000 01]、创面愈合时间缩短[SMD=-0.81,95％CI(-1.00,-0.62),P＜0.000 01]、住院时间缩短[MD=-7.11,95％CI(-8.12,-6.11),P＜0.000 01]、细菌阳性率降低[RR=0.35,95％CI(0.22,0.54),P＜0.000 01];两组疼痛评分比较差异无显著意义[SMD=-5.97,95％CI(-14.33,2.40),P=0.16];③结果表明,富血小板血浆联合负压引流疗法能促进慢性难愈性创面的愈合,降低感染发生率.

ObjectiveTo systematically evaluate application effect of multi-mode preemptive analgesia in rehabilitation nursing of patients after hip arthroplasty.MethodsRandomized controlled trials on application of multi-mode preemptive analgesia in postoperative rehabilitation care of patients undergoing hip arthroplasty,were retrieved from the following databases:the Cochrane Library,Web of Science,Google academic,IOP Science,Elsevier,EMbase,PubMed,Science Direct,China Journal full-text Database (CJFD),China Biology Medicine disc(CBM),Wanfang,China National Knowledge Infrastructure(CNKI),VIP,Chaoxing Digital,Reading Show resources and Baidu academic resource system.The retrieval time was up to June 1,2019.Screening of literatures,extraction of data, and quality evaluation of included literatures were conducted by two researchers.Then meta analysis was carried out by using software RevMan 5.3.ResultsA total of 8 literatures were included,involving 639 patients.The patients in experimental group were treated with two or more analgesia methods,such as preoperative education,oral drugs,analgesia pump,intravenous injection,local infiltration,nerve block,ice compress and so on.The patients in control group were treated with one of the above methods.The results of Meta analysis showed that the Visual Analogue Score(VAS)at 72 h in the experimental group was lower than that in the control group[SMD=-1.67,95%CI(-3.19,-0.16),P<0.05].And the score of Harris in the experimental group was higher than that in the control group [SMD=3.04,95%CI(0.87,5.20),P<0.05].Dosage of opioids in the experimental group was less than that in the control group [SMD=-0.68,95%CI(-1.23,-0.14),P<0.05].In addition,the incidence of adverse reactions in the experimental group was less than that in the control group[OR=0.41,95%CI(0.23,0.73),P<0.05].ConclusionsCurrent evidence showed that multi-mode preemptive analgesia can effectively reduce the pain degree of patients after hip arthroplasty,promote the recovery of joint function,and reduce the dosage of opioids and the incidence of adverse reactions.