The nervous system regulates liver function, and liver diseases can in turn cause neurological dysfunction. Recent research has revealed the intricate relationship between the nervous system and liver, presenting the importance in maintaining homeostasis and regulating various physiological and pathological processes. This article focuses on the ways in which the nervous system regulates liver diseases in innervation, immune system and hepatic metabolism, and the specific mechanisms by which liver diseases affect the nervous system, in order to offer a theoretical basis and new insights for future disease management.

疼痛是一种令人不愉快的感觉和情感体验,严重影响患者的生活质量,造成极大的社会和经济问题.疼痛包括疼痛的感知觉、行为防御反应、情绪反馈及下行调控等.脊髓神经元参与疼痛感知和调控的重要过程,具体包括接收外周疼痛信号的传入,传递疼痛信息上行以及作为疼痛下行调控的效应部位.本文将脊髓神经元参与疼痛相关的上行传导及下行调控环路研究进展作简要综述,探索疼痛发生发展可能的生理和病理机制,为进一步探究脊髓及其上游高级中枢在疼痛的调控中的作用机制提供参考.

目的 评价肿瘤相关巨噬细胞(TAMs)与非小细胞肺癌(NSCLC)预后的关联,为采取早期干预措施提供依据.方法 计算机检索PubMed、EMBASE、MEDLINE、CBM、万方数据库、维普数据库中自建库至2018年6月20日公开发表的TAMs与NSCLC预后关联的中英文临床研究进行Meta分析,采用纽卡斯尔-渥太华量表(NOS)评价研究质量,采用χ2检验进行异质性检验,采用固定效应模型或随机效应模型进行汇总分析.结果 检索并纳入14篇有关NSCLC患者的5年生存率与病理组织内TAMs性质关系的研究.Meta分析结果显示:总TAMs密度(OR=3.55,95％CI 1.62～7.78,P=0.002)、肿瘤细胞团内TAMs密度(OR=0.43,95％CI 0.19～0.97,P=0.04)、肿瘤基质内TAMs密度(OR=1.82,95％CI 1.19～2.78,P=0.006)、肿瘤基质内M2巨噬细胞密度(OR=2.01,95％CI 1.17～3.45,P=0.01)与5年生存率相关.结论 TAMs可作为预测NSCLC患者预后的指标,对临床有重要的指导意义.

In this study,the function of chicken mitochondrial anti-viral signaling protein(MAVS)in the type Ⅰ IFN signaling pathway was investigated.Alignment of the chicken MAVS(chMAVS)deduced amino acid sequence indicated that the major functional domains are not conserved in chMAVS compared with that of mammalian MAVS.Phylogenetic analysis demonstrated that chMAVS exhibited a strong evolutionary relationship with turkey and quail MAVS.Furthermore,levels of chMAVS and IFN-β mRNA increased in DF-1 cells infected with Newcastle disease virus(NDV),and reaching their highest level at 12h.Overexpression of chMAVS induced IFN-β activation in DF-1 cells.Together,these results indicate that chicken MAVS played a critical role in inducing IFN-β,and laid foundations for the further study of avian innate antiviral immune pathway.