目的 研究TLR4 rs1927907、rs11536889基因多态性与慢性牙周炎及COPD下游炎性通路中细胞因子的关系.方法 选择慢性牙周炎患者81例,COPD患者27例,慢性牙周炎伴COPD患者76例,健康对照者26例.采集所有受试对象的静脉血,分离血细胞与血清.提取白细胞基因组DNA,采用TaqMan MGB探针法对TLR4 rs1927907、rs11536889进行基因型检测.采用酶联免疫吸附法检测血清中IL-1β、IL-6、TNF-α 的水平.结果 牙周炎组,rs11536889 GG基因型患者血清中的TNF-α 水平显著低于GC+CC基因型患者(P=0.038).慢性牙周炎伴COPD组中,rs11536889 GG基因型患者血清中的IL-6水平显著高于GC+CC基因型患者(P=0.006).其余2组rs1927907、rs11536889基因型与血清中IL-1β、IL-6、TNF-α 水平无显著差异(P>0.05).结论 在慢性牙周炎组和慢性牙周炎伴COPD组中,TLR4 rs11536889基因多态性与TNF-α、IL-6的表达有关,可能增强了机体介导的炎症反应.

With the development of contemporary medicine,oral implantology has been accepted by more and more patients.Alveolar bone resorption is the common outcome after tooth extraction.Lack of fixed and support around the implant bone tissue will have a significant influence on the stability of the implant.The shortage of alveolar bone is the biggest problem we are facing.Ridge preservation is a series of treatments aiming at limiting alveolar bone resorption after tooth extraction and stimulating new bone formation.At present,commonly used ridge preservation technology are instant implantation,bone graft and so on.In the paper,the concept methods of ridge preservation and the preservation technology status were reviewed.For clinical ridge preservation technology provide theoretical basis for the application.

目的:分析正畸治疗在先天性牙缺失患者修复前的应用.方法:选取10例来我院进行正畸治疗先天性恒牙缺失的患者,根据患者的情况制定治疗方案,通过对患者进行正畸治疗、纠正错牙和畸形、行固定桥修复缺牙间隙,达到修复先天性恒牙缺失的目的.结果:经过患者3年来的配合治疗以及术后观察,进行先天性牙缺失修复的患者治疗后没有出现基牙松动或者移位,且基牙龈边缘健康,患者很满意.结论:在修复先天性牙缺失前进行正畸治疗不仅能改善患者口腔功能,还能增加口腔美观效果,保护基牙健康.