脊膜瘤是一种发生于椎管内的良性肿瘤,多起源于内皮细胞或纤维细胞,其发病率仅次于神经源性肿瘤,约占椎管内肿瘤的25% [1] 。主要发生于40~70岁的女性,其中约75%~83%发生在胸椎 [2] ,女性∶男性为5.8∶1 [3] 。脊膜瘤对放化疗等不敏感,通常需要手术完整切除肿瘤,预后满意,复发率低 [4] 。大部分脊膜瘤为硬膜下髓外占位性病变,极小
目的：探讨后路一期全脊椎切除及脊柱稳定性重建术对胸腰椎单脊椎脊柱转移癌的术后疗效。方法手术治疗的脊柱转移癌患者15例均行后路病变椎体切除、受压脊髓360°环形减压，人工椎体VBOSS椎体支持系统植骨融合、后路椎弓根螺钉系统重建脊柱的稳定性，比较手术前后疼痛程度及神经功能状态的改善及预后。结果均获得随访资料（3～18个月），术后疼痛程度明显改善，视觉模拟评分（VAS）从术前（5.07±1.33）分下降到术后（2.13±1.30）分（P＜0.05）。14例术前有神经功能障碍者10例大部分恢复，4例部分恢复，Frankel分级从术前的（3.60±0.83）上升到术后的（4.43±0.46）（P＜0.05）。随访过程中1例乳腺癌患者和1例肺癌患者死亡，余植骨融合良好，椎弓根螺钉无松动，病椎切除周围未见复发。结论对于转移癌累及脊柱胸腰椎单节段的患者，后路一期全脊椎病变切除及脊柱稳定性重建术能减轻患者的疼痛程度及神经功能恢复，明显改善生活质量。
Objective To study the expression ofβ-catenin protein in cervical intervertebral disc herniation,and to analyze the clinical significance.Methods The expression ofβ-catenin protein in 16 cases of cervical intervertebral disc herniation and 5 cases normal cervical intervertebral disc tissue were detected by immunohistochemistry.Results β-catenin protein showed high expression in the degeneration of cervical intervertebral disc tissue.However,it has no ex-pression in the control group of normal cervical intervertebral disc tissue,it has statistical significance (P <0.01).Con-clusion β-catenin protein might play a role in the development of degeneration of cervical intervertebral disc tissue.
