脊柱嗜酸性肉芽肿（EG）是一种以骨质破坏、组织细胞增生和嗜酸性细胞浸润为主要特点的良性肿瘤样疾病。该病起病隐匿,患者最初的临床症状往往缺乏特异性,常以局部疼痛或病理性骨折就诊。且早期实验室检查与影像学表现也缺乏特异性,Fermando等[1]对其所穿刺活检的患者进行统计,发现穿刺活检的阳性率不足50%。所以临床中对于

脊膜瘤是一种发生于椎管内的良性肿瘤,多起源于内皮细胞或纤维细胞,其发病率仅次于神经源性肿瘤,约占椎管内肿瘤的25% [1] 。主要发生于40~70岁的女性,其中约75%~83%发生在胸椎 [2] ,女性∶男性为5.8∶1 [3] 。脊膜瘤对放化疗等不敏感,通常需要手术完整切除肿瘤,预后满意,复发率低 [4] 。大部分脊膜瘤为硬膜下髓外占位性病变,极小

目的：探讨后路一期全脊椎切除及脊柱稳定性重建术对胸腰椎单脊椎脊柱转移癌的术后疗效。方法手术治疗的脊柱转移癌患者15例均行后路病变椎体切除、受压脊髓360°环形减压，人工椎体VBOSS椎体支持系统植骨融合、后路椎弓根螺钉系统重建脊柱的稳定性，比较手术前后疼痛程度及神经功能状态的改善及预后。结果均获得随访资料（3～18个月），术后疼痛程度明显改善，视觉模拟评分（VAS）从术前（5.07±1.33）分下降到术后（2.13±1.30）分（P＜0.05）。14例术前有神经功能障碍者10例大部分恢复，4例部分恢复，Frankel分级从术前的（3.60±0.83）上升到术后的（4.43±0.46）（P＜0.05）。随访过程中1例乳腺癌患者和1例肺癌患者死亡，余植骨融合良好，椎弓根螺钉无松动，病椎切除周围未见复发。结论对于转移癌累及脊柱胸腰椎单节段的患者，后路一期全脊椎病变切除及脊柱稳定性重建术能减轻患者的疼痛程度及神经功能恢复，明显改善生活质量。

C17H17NO4, monoclinic, C2/c (no. 15), a = 24.367(3) Å, b = 6.2556(6) Å, c = 20.854(2) Å, β = 110.016(2)°, V = 2986.9(5) Å3, Z = 8, Rgt(F) = 0.0539, wRref(F2) = 0.1578, T = 293(2) K.

Objective To study the expression ofβ-catenin protein in cervical intervertebral disc herniation,and to analyze the clinical significance.Methods The expression ofβ-catenin protein in 16 cases of cervical intervertebral disc herniation and 5 cases normal cervical intervertebral disc tissue were detected by immunohistochemistry.Results β-catenin protein showed high expression in the degeneration of cervical intervertebral disc tissue.However,it has no ex-pression in the control group of normal cervical intervertebral disc tissue,it has statistical significance (P <0.01).Con-clusion β-catenin protein might play a role in the development of degeneration of cervical intervertebral disc tissue.

Abstract C24H23NO4, monoclinic, P21/n (no. 14), a = 13.492(6) Å, b = 9.259(4) Å, c = 15.993(8) Å, β = 94.009(9)°, V = 1993.0(16) Å3, Z = 4, R gt (F) = 0.0409, wR ref (F 2) = 0.1201, T = 293(2) K.

目的 探讨不同手术方法治疗不稳定Hangman骨折的临床疗效.方法 14例不稳定Hangman骨折患者根据Levine-Edwards分型:Ⅱ型7例,ⅡA型5例,Ⅲ型2例.4例行后路C2.3椎弓根螺钉内固定术,7例行前路C23间盘摘除减压植骨融合内固定术,3例行前后路联合手术.结果 患者均获随访,时间3 ～ 24个月.1例患者术后3个月单侧椎弓根处可见模糊骨折线,13例患者均达到骨性愈合.术中及术后未出现椎动脉、脊髓损伤及脑脊液漏等并发症,未发生钢板螺钉断裂内固定失效等现象.结论 对于不稳定Hangman骨折无论是采取前路或者后路手术均可使骨折达到骨性愈合,对严重骨折伴脱位Hangman骨折可以采取前后路联合的手术方式.

Two 4,4′-[1,3-phenylenebis(oxy)]dibenzoate anions bridge two 1,10-phenanthroline-chelated ZnII cations about a center of inversion to generate the dinuclear title compound, [Zn2(C20H12O6)2(C12H8N2)2]·2H2O. The geometry about the ZnII atom is a distorted octahedron. In the crystal, the molecules are connected by classical O—H...O hydrogen bonds, weak C—H...O hydrogen bonds and C—H...π interactions, forming a three dimensional network. π–π stacking is also observed between aromatic rings of adjacent molecules, centroid–centroid distances are 3.753 (2), 3.5429 (16) and 3.5695 (17) Å.

The aim of the present study was to investigate the ultrastructure and content of collagen in uterosacral ligaments and paraurethral tissues in patients with pelvic organ prolapse (POP) and stress urinary incontinence (SUI), analyzing the association between POP and collagen dysfunction. The study comprised three groups: Control, POP and POP with SUI (n=30 per group). Histological characteristics of collagen fiber were observed and the diameters were measured using light and electron microscopy to determine the Type I and Type III collagen content of the main ligament in the urethral specimens. In the POP and POP with SUI groups, observations included diffuse atrophy of smooth muscles, active fibroblast metabolism, swollen mitochondria and visible Golgi apparatus. The collagen fibril diameters in the cardinal ligaments, uterosacral ligaments and paraurethral tissues were significantly greater in the POP and POP with SUI groups compared with those in the control group (P<0.01). In addition, the expression levels of Type I and Type III collagen were significantly lower in the POP and POP with SUI groups when compared with the control group (P<0.01). In the POP with SUI group, pelvic tissues were frail, resulting in smooth muscle bundles comminuting and arranging in a disorganized pattern. Fibroblast and myoblast metabolisms were active and new microvascular cells were weak. However, the collagen fibril diameter increased. Thus, collagen and ultrastructural changes in the pelvic floor may be associated with the development of POP and SUI.

In the title salt, [Zn(C6H15NO3)2](C8H4O4), the Zn(II) cation, located on a centre of inversion, is coordinated by four O atoms and two N atoms from two tridentate 2-[bis-(2-hy-droxy-eth-yl)amino]-ethanol (BHEA) ligands, giving rise to a slightly distorted octa-hedral geometry. The terephthalate dianion, located about a centre of inversion, is not coordinated to Zn(II) but is connected through O-H⋯O contacts with [Zn(BHEA)2](2+) cations, leading to a three-dimensional crystal structure.

The asymmetric unit of the title compound, [Mn3(C12H6O12)(H2O)6] n , comprises one Mn(II) ion, one third of a cyclo-hexane-1,2,3,4,5,6-hexa-carboxyl-ate anion and two aqua ligands. The anion is completed by application of a -3 axis. The Mn(II) ion is six-coordinated by six O atoms from two aqua ligands and three different cyclo-hexa-carboxyl-ate anions in an octa-hedral geometry. The six carboxyl-ate groups adopt a bridging bidentate mode to ligate the Mn(II) ions. Thus, each cyclo-hexane-1,2,3,4,5,6-hexa-carboxyl-ate anion adopts a μ9-connected mode, ligating nine different Mn(II) ions and forming a three-dimensional framework. In the framework, there are strong O-H⋯O hydrogen-bonding inter-actions, which further stabilize the crystal structure.

The asymmetric unit of the title compound, [Mn3(C12H6O12)(H2O)6]n, comprises one MnII ion, one third of a cyclohexane-1,2,3,4,5,6-hexacarboxylate anion and two aqua ligands. The anion is completed by application of a -3 axis. The MnII ion is six-coordinated by six O atoms from two aqua ligands and three different cyclohexacarboxylate anions in an octahedral geometry. The six carboxylate groups adopt a bridging bidentate mode to ligate the MnII ions. Thus, each cyclohexane-1,2,3,4,5,6-hexacarboxylate anion adopts a μ9-connected mode, ligating nine different MnII ions and forming a three-dimensional framework. In the framework, there are strong O—H...O hydrogen-bonding interactions, which further stabilize the crystal structure.

In the title compound, C24H17N2O4+&#183;NO3&#8722;&#183;0.25H2O, the central pyridine ring of the 2&#8242;,6&#8242;-bis(4-carboxyphenyl)-4,4&#8242;-bipyridin-1-ium cation is almost coplanar with one benzene ring [dihedral angle = 1.03&#8197;(5)&#176;], while it makes dihedral angles of 9.59&#8197;(5)&#176; with the other benzene ring and 13.66&#8197;(6)&#176; with the pyridinium ring. In the crystal, N&#8212;H...O and O&#8212;H...O hydrogen bonds link the cations and nitrate anions into a sheet in the (302) plane. The crystal structure also exhibits &#960;&#8211;&#960; interactions between the central pyridine ring and the benzene rings of neighboring molecules [centroid&#8211;centroid distance = 3.6756&#8197;(13)&#8197;&#197;].

In the title compound, {[Zn(C8H5N2O2S)2]·3H2O}n, the ZnII atom, lying on a twofold rotation axis, is four-coordinated by two S atoms and two O atoms from four 2-sulfido-1H-benzimidazol-3-ium-5-carboxylate (H2mbidc) ligands in a distorted tetrahedral geometry. Two H2mbidc ligands bridge two ZnII atoms, generating a double-chain along [01]. Adjacent chains are linked by N—H⋯O and O—H⋯O hydrogen bonds, forming a three-dimensional supramolecular network. One of the two water molecules also lies on a twofold rotation axis.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

In the title compound, {[Zn(C8H5N2O2S)2]&#183;3H2O}n, the ZnII atom, lying on a twofold rotation axis, is four-coordinated by two S atoms and two O atoms from four 2-sulfido-1H-benzimidazol-3-ium-5-carboxylate (H2mbidc) ligands in a distorted tetrahedral geometry. Two H2mbidc ligands bridge two ZnII atoms, generating a double-chain along [overline{1}01]. Adjacent chains are linked by N&#8212;H...O and O&#8212;H...O hydrogen bonds, forming a three-dimensional supramolecular network. One of the two water molecules also lies on a twofold rotation axis.

In the title compound, C(24)H(17)N(2)O(4) (+)·NO(3) (-)·0.25H(2)O, the central pyridine ring of the 2',6'-bis-(4-carb-oxy-phen-yl)-4,4'-bipyridin-1-ium cation is almost coplanar with one benzene ring [dihedral angle = 1.03 (5)°], while it makes dihedral angles of 9.59 (5)° with the other benzene ring and 13.66 (6)° with the pyridinium ring. In the crystal, N-H⋯O and O-H⋯O hydrogen bonds link the cations and nitrate anions into a sheet in the (302) plane. The crystal structure also exhibits π-π inter-actions between the central pyridine ring and the benzene rings of neighboring mol-ecules [centroid-centroid distance = 3.6756 (13) Å].