Purpose: To investigate the role of FOXQ1 in the progression of epithelial ovarian cancer and the underlying mechanism. Methods: Forkhead Box Q1 overexpression was evaluated by quantitative reverse-transcription (qRT-PCR) in clinical epithelial ovarian cancer samples and cell lines. Proliferation, migration, and invasion of cancer cells were determined using CCK8, wound healing and transwell assay. Results: FOXQ1 depletion inhibited the proliferation, migration, and invasion of 'epithelial ovarian cancer cells. Moreover, FOXQ1 overexpression increased the amount of cells in S phase of the cell cycle, and FOXQ1 knockdown arrested cells in G1 phase. Results from ChIP and luciferase reporter assays showed that FOXQ1 was able to bind SIRT1 promoters. In addition, it was involved in sustaining the stability of nuclear factor erythroid derived 2-like 2 (NRF2) by decreasing its acetylation (p < 0.01), which was mediated by SIRT1. The data also demonstrated that NRF2 promotes proliferation, migration, and invasion of cancer cells upon FOXQ1 overexpression. Conclusion: Forkhead Box Q1 contributes to the progression of epithelial ovarian cancer partly via SIRT1/NRF2 signaling pathway, this highlighting a novel strategy for treating epithelial ovarian cancer.

目的:探讨早期宫颈癌患者术前血浆人附睾蛋白4(human epididymis protein 4,HE4)水平对复发的影响.方法:以186例早期宫颈癌患者为研究对象,根据术前血浆HE4水平分为低HE4组(＜327.6 pmol/L)93例和高HE4组(≥327.6 pmol/L)93例.应用Kaplan-Meier法估算生存率,应用Log-rank检验比较低HE4组和高HE4组的生存曲线.采用Cox比例风险回归分析宫颈癌复发的危险因素.结果:绝经、肌层浸润深度≥1/2、淋巴结转移、肿瘤直径≥4 cm、Ⅱa期均为影响HF4水平的独立因素.低HE4组有10例复发,复发时间中位数为41.5(25.0～62.0)个月,高HE4组有20例复发,复发时间中位数为25(5～50)个月.与低HE4组相比,高HE4组无复发生存率显著下降.多因素分析结果显示术后辅助治疗是早期宫颈癌术后复发的独立保护因素,而Ⅱa期、淋巴结转移及术前血浆HE4水平≥327.6 pmol/L为影响早期宫颈癌术后复发的独立危险因素.结论:术前血浆HE4水平升高是早期宫颈癌患者术后复发的危险因素,对宫颈癌患者预后判断具有潜在应用价值.

目的 探讨拉贝洛尔联合甲基多巴治疗妊娠期高血压疾病的疗效,及其对患者血流动力学指标和母婴妊娠结局的影响.方法 选取2016年8月-2017年10月本院接诊的妊娠期高血压疾病患者100例作为研究对象,依据随机数字表法平均分为对照组和观察组,对照组患者给予静脉滴注硫酸镁治疗,观察组在对照组治疗基础上给予拉贝洛尔联合甲基多巴治疗.比较两组治疗后有效率、血流动力学指标水平及不良妊娠率.结果 观察组治疗后总有效率为92.00％,显著高于对照组的82.00％,差异有统计学意义(x2=4.421,P=0.036);观察组治疗后中心静脉压(MAP)、外周阻力水平均显著低于对照组,心脏指数显著高于对照组,差异有统计学意义(P<0.05);观察组不良妊娠率为12.00％,显著低于对照组的28.00％,差异有统计学意义(x2=8.000,P=0.005).结论 拉贝洛尔联合甲基多巴可有效提高妊娠期高血压疾病的治疗有效率,改善患者血流动力学指标水平,减少不良妊娠结局的发生.

目的:研究妊娠期高血压孕妇妊娠晚期甲状腺功能的异常情况.方法:选择2015年11月—2017年11月于我院就诊的妊娠期高血压孕妇,共90例,回顾性分析患者在临床上一般资料,并进行甲状腺功能的异常筛查.结果:引发甲状腺功能异常的因素有很多,除糖尿病和分娩史之外,与年龄、流产史、胆固醇等,具有统计学意义(P<0.05).结论:针对妊娠期高血压患者需要正确认识妊娠晚期甲状腺功能的变化,对于预防异常情况至关重要.

Lutein is widely found in nature,a safe and natural pigments,which can play an important anti-tumor role by inhibiting tumor cell proliferation,inducing differentiation and promotingapoptosis.Lutein is a carotenoid contained ionone ring,with multiple conjugated double bonds,so it has a strong ability of free radical scavenging,which can also play many biological functions in antioxidant,preventing cataracts,dela-ying atherosclerosis and anti-tumor process.Here is to make a review of the research status in lutein's anti-tumor function in the domestic and overseas field .