Objective:To assess the role of Glasgow prognostic score (GPS) in the prognostic evaluation of nasopharyngeal carcinoma patients.Methods:Clinical data of 129 nasopharyngeal carcinoma patients who received radical radiotherapy in Affiliated Hospital of Jiangnan University from January 2012 to December 2013 were retrospectively analyzed. Clinicopathological characteristics of the patients were collected, including gender, age, TNM staging, pathological type and treatment regimen, etc. The GPS before and at 3 months after radiotherapy were calculated. The survival curve was drawn by the Kaplan- Meier method. Cox regression model was used for analysis of prognostic factors. The area under the receiver operating characteristic (ROC) curve (AUC) was utilized to evaluate the predictive capability of clinical parameters on prognosis. Results:With a median follow-up of 89.0 months (range: 5.1-104.6 months), the 5-year progression-free survival (PFS) of 129 patients was 79.8% and 84.5% for the 5-year overall survival (OS). At 3 months after radiotherapy, the 5-year PFS were 85.6%, 61.1% and 33.3% in the GPS 0, 1 and 2 groups, and 90.4%, 66.7% and 33.3% for the 5-year OS, respectively (all P<0.01). At 3 months after radiotherapy, the GPS, clinical staging (Ⅰ-Ⅲ vs. Ⅳ A) and concurrent chemotherapy were significantly correlated with PFS and OS (all P<0.01). ROC curve showed that at 3 months after radiotherapy, the AUC values of GPS, clinical staging and two combined in predicting OS were 0.694, 0.815 and 0.860, respectively. Conclusions:At 3 months after radiotherapy, higher GPS is an independent poor prognostic factor for nasopharyngeal carcinoma patients. The combination of GPS and clinical staging yields high accuracy in the prognostic evaluation of nasopharyngeal carcinoma patients.

目的 探讨术后PNI在胃癌患者预后评估中的临床价值.方法 回顾性分析术后胃癌Ⅲ期患者91例,根据术后、首次化疗前的外周血液指标计算出PNI、外周血中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、全身炎症指数(SII)等营养综合指标,通过ROC曲线计算出PNI最佳截断值.根据PNI最佳截断值将其分为低PNI组(PNI<42.3)和高PNI组(PNI≥42.3),根据PNI分组预测胃癌患者的预后.应用Cox回归模型进行单因素回归分析和多因素分析.结果 多因素分析结果显示术后PNI(P=0.004)及分期(P=0.009)是影响胃癌患者总生存时间的独立预后因素.结论 术后PNI是预测胃癌患者预后的独立因素,且低PNI和高分期与患者预后不良相关.

目的 探讨宫颈长度测量联合胎儿纤维连接蛋白(fFN)测定对早产的预测价值.方法 采用ELISA定量测定28～34周先兆早产孕妇阴道分泌物中的fFN水平,同时经阴道B超测量宫颈长度.分析fFN定量及测量宫颈长度对7d内早产的预测价值.结果 353例有先兆早产症状的孕妇中,34例(9.6％)在7 d内发生早产.在宫颈长度＜20 mm的孕妇中,当取25 ng/ml作为fFN临界值时,31例被认为是低风险,其中1例(3.2％)在7d内发生早产.fFN≥25 ng/ml者的7d早产率高于＜25 ng/ml者(29.3％vs.3.2％)(P＜0.01).在宫颈长度≥20 mm的孕妇中,当fFN临界值取200 ng/ml时,63例被认为是高风险,其中6例(9.5％)在7d内发生早产.fFN≥200 ng/ml者的7d早产率高于＜200 ng/ml者(9.5％vs.2.7％)(P＜0.05).有先兆早产症状的孕妇7d早产率与宫颈长度呈负相关(P＜0.05),而与fFN浓度呈正相关(P＜0.05).结论 fFN定量检测联合宫颈长度测量能够提高先兆早产孕妇在7d内早产的预测价值.