Pelvic abscess is one of the most common gynecologic acute abdomen.It is often developed by pelvic inflammatory disease,and the incidence of the pelvic abscess is rising year by year and younger.It often leads to a variety of diseases,such as infertility,which threaten female reproductive health.Its clinical symptoms vary and progress rapidly,which can easily lead to misdiagnosis or untimely rupture of abscess,and seriously endanger life.For pelvic abscess,correct diagnosis and timely treatment are the fundamental starting point.This article reviews the progress in the diagnosis and treatment of pelvic abscess.

High mobility group protein B1 (HMGB1) is a DNA binding protein that can induce cytokines to be secreted and activate inflammatory cells to participate in inflammatory reactions. Recent studies on its role in the inflammatory response to endometriosis have gradually increased. Endometriosis is a benign inflammatory disease with increasing incidence year by year, mostly in women of childbearing age. This disease mainly causes the clinical manifestations of dysmenorrhea and chronic pelvic pain. Endometriosis usually plays a synergistic role in inflammatory immune, lesion tissue invasion, adhesion and other factors, resulting the changes in the pelvic microenvironment. The mechanism of endometriosis is not completely clear, but the role of inflammatory reaction and stimulation can not be ignored. HMGB1 can increase the release of inflammatory factors and cause the body to produce pain, and the expression of HMGB1 in the endometriosis patients is significantly increased. The inflammatory response and pain can be alleviated by reducing the concentration of HMGB1 in the body of endometriosis patients. Pain and other symptoms suggest that HMGB1 may become an important target for the treatment of endometriosis.

子宫内膜异位症(EMs,简称内异症)是一种症状和外观表现多样的异质性疾病.不孕是EMs最常见的症状之一,常合并盆腔疼痛.内异症相关不孕发病率高达50%,但具体机制尚不明确.免疫机制是EMT的发病机制之一,关于EMs免疫机制引起不孕的研究日益增多,特别是单核-巨噬细胞免疫系统.对EMs相关不孕的发病机制进行深入研究,可能有助于发展有针对性的治疗方法和改进诊断方法.

<正>钙离子(Ca2+)是细胞信号传导过程中重要的第二信使,在细胞内传递信息并调控一系列生命过程。当细胞受到相应刺激时,细胞会通过各种途径升高细胞内Ca2+浓度,胞浆内Ca2+浓度的升高主要来源于2个方面:外钙内流和细胞内钙库释放。外钙内流的途径主要分成3大类:电压门控的钙通道(voltage depentent calcium chnnel,VOC)、受体门控的钙通道(receptor operated

<正>目的:观察钙敏感受体(CaSR)在心肌梗死病人外周血T淋巴细胞上的表达和对细胞因子分泌的影响及其与信号转导通路的关系。方法:取心肌肌钙蛋白I(cTnI)测定值高于正常值、临床确诊为心肌梗死的病人外周血T淋巴细胞作为研究对象;