Objective: To investigate the association between brain-derived neurotrophic factor(BDNF) gene polymorphisms and the onset age as well as levels of clinical symptoms in patients with schizophrenia. Method:A hundred and eleven patients were included with informed consent.80 eligible patients entered into the 4-week treatment study and the serum BDNF,the positive and negative syndrome scale(PANSS) and the personal and social performance scale(PSP)were assessed before and after treatment.The BDNF polymorphism(rs6265 and rs11030101)was genotyped using a taqman probe technology.BDNF gene single nucleotide polymorphism(rs6265 and rs11030101)genotypic and allelic distributions were compared with the clinical characters of schizophrenia. Results:The genotypic and allelic distribution of rs6265 and rs11030101 had no relationship with the onset age,gender,type in patients with schizophrenia.The mean scores of PANSS-negative and the improvement scores of the personal and PSP were significantly different among three rs6265 genotypes after 4-week treatment(F=3.442,P=0.037;F=4.129,P=0.020). Conclusion:Schizophrenic patients demonstrate impairments in social function,which could be improved with short-term treatment of antipsychotics.The BDNF gene polymorphism is related to negative symptoms and social function after 4-week antipsychotic treatment.The rs6265 A/A genotype showed significant less negative symptoms and more improvement of social function after treatment.

目的 探讨精神分裂症患者治疗前后的血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平及其与症状、认知功能的关系.方法 收集74例入组前1个月内未用药的精神分裂症患者(患者组),给予单一的抗精神病药治疗4周,检测其治疗前后的血清BDNF浓度,并与来自体检人群的153名正常对照作比较;采用威斯康星卡片分类测验(wisconsin card sorting test,WCST)评定患者组治疗前后的执行功能,并与另89名正常对照比较;应用阳性和阴性症状量表(PANSS)评估患者的精神症状.结果 治疗前患者组血清BDNF浓度低于对照组[(20.64±6.32) ng/mL vs (23.72±5.61) ng/mL,P<0.01];治疗后BDNF浓度升高(t=-2.48,P=0.02)且与对照组的差异无统计学意义(P>0.05),PANSS总分下降 (t=21.13,P<0.01),WCST成绩虽有提高,但与对照组比较,完成分类数仍较少,错误应答数、持续错误数及非持续错误数较多,差异有统计学意义(P<0.05).治疗后患者组的BDNF浓度、WCST及PANSS总分之间无相关性(P<0.05).结论 精神分裂症患者外周血的BDNF浓度降低,认知功能受损,治疗后症状改善,认知功能与BDNF浓度同步提高.

近年来,大陆与港台地区之间各方面交流日益增多,本文简单介绍台湾香港地区的精神科教育现状,希望能有所借鉴.

随着社会的开放以及知识的普及,精神疾病已经逐渐得到人们的重视.然而除了精神疾病病因学和药物学等方面研究的不断进展,精神疾病患者的心理问题也是人们关注的话题.