A Body Shape Index (ABSI) is a composite metric designed to more accurately assess an individual's body size and associated health risks. This study aimed to explore the potential relationship between ABSI and constipation. A total of 11,336 participants from the National Health and Nutrition Examination Survey 2005 to 2010 were included. Multivariable logistic regression models were used to evaluate the association between ABSI and constipation after adjustment for potential confounders. Restricted cubic spline analysis was performed to explore potential nonlinear associations. Subgroup and interaction analyses were conducted to assess whether the association differed across demographic and clinical characteristics. The multivariate logistic regression analysis, fully adjusted for confounders, indicated that an increase in ABSI was associated with a decrease in the incidence of constipation when ABSI was below 0.082 (OR = 5.88, 95% CI: 2.17-9.59, P < .01). Subgroup analysis and interaction tests revealed a significant positive association between ABSI and constipation, particularly in males, individuals with a college education or higher, alcohol users, as well as those with hypertension and diabetes. This study identified a relationship between ABSI and the incidence of constipation, suggesting that a reduction in ABSI, within specific limits, is linked to a decreased risk of constipation.

A Body Shape Index (ABSI) is a composite metric designed to more accurately assess an individual’s body size and associated health risks. This study aimed to explore the potential relationship between ABSI and constipation. A total of 11,336 participants from the National Health and Nutrition Examination Survey 2005 to 2010 were included. Multivariable logistic regression models were used to evaluate the association between ABSI and constipation after adjustment for potential confounders. Restricted cubic spline analysis was performed to explore potential nonlinear associations. Subgroup and interaction analyses were conducted to assess whether the association differed across demographic and clinical characteristics. The multivariate logistic regression analysis, fully adjusted for confounders, indicated that an increase in ABSI was associated with a decrease in the incidence of constipation when ABSI was below 0.082 (OR = 5.88, 95% CI: 2.17–9.59, P < .01). Subgroup analysis and interaction tests revealed a significant positive association between ABSI and constipation, particularly in males, individuals with a college education or higher, alcohol users, as well as those with hypertension and diabetes. This study identified a relationship between ABSI and the incidence of constipation, suggesting that a reduction in ABSI, within specific limits, is linked to a decreased risk of constipation.

Introduction: Di-(2-ethylhexyl) phthalate (DEHP) is a widely used environmental plasticizer. Although environmental pollutants are increasingly implicated in inflammatory bowel disease, how DEHP-related molecular programs connect to Crohn’s disease (CD)-associated intestinal remodeling remains unclear.Objective: This study aimed to investigate the associations among DEHP-related molecular programs, CD-associated inflammation, tissue remodeling, and their corresponding cellular-state contexts.Methods: DEHP candidate targets were predicted using ChEMBL, PharmMapper, and SwissTargetPrediction. Public CD transcriptomic cohorts underwent differential expression and weighted gene co-expression network analyses. Multi-algorithm machine learning and SHAP prioritized candidate genes. Single-cell RNA sequencing evaluated disease-aligned cell-state mapping. Additionally, molecular docking, dynamics simulations, a DSS-induced colitis model, and primary mouse intestinal fibroblast exposure experiments were conducted.Results: Multi-omics integration identified a transcriptional intersection among predicted DEHP targets, CD differentially expressed genes, and disease-associated co-expression modules. ANXA3, DUSP6, IGFBP2, and TNFSF13 emerged as a core disease-discriminative feature combination. Single-cell projection mapped this molecular program preferentially to inflammatory fibroblast-associated disease states, with latent vector analysis suggesting continuous disease-aligned state shifts. Simulations indicated potential structural compatibility between DEHP and candidate proteins. In vivo, DEHP aggravated DSS-induced intestinal inflammation and dysregulated these core genes. Primary fibroblast experiments confirmed candidate gene-axis alterations alongside increased extracellular matrix and inflammatory remodeling markers.Conclusions: This study establishes a cross-scale DEHP-CD candidate gene-cell state framework, directly linking environmental plasticizer exposure with CD-associated inflammatory fibroblast remodeling, thereby providing clues for future mechanistic validation.

Background: Janus-kinase (JAK) inhibitors are increasingly used across surgical practice for immune-mediated disorders, yet their gastrointestinal (GI) safety profiles remain incompletely defined. Upadacitinib (selective JAK-1) has been linked to severe mucosal complications, whereas ruxolitinib (JAK-1/2) appears better tolerated. Robust real-world comparisons are lacking. Methods: We performed a retrospective, observational pharmacovigilance study of the FDA Adverse Event Reporting System from 1 July 2019 to 31 December 2024. After deduplication, 58 548 upadacitinib and 28 968 ruxolitinib safety reports were retrieved. GI events were coded with MedDRA and grouped into inflammation, ulcer/perforation, bleeding, motility disorders, symptoms and other serious events. Multivariable logistic regression generated adjusted reporting odds ratios (aROR) for ruxolitinib versus upadacitinib, controlling for age, sex, comorbidities and concomitant NSAIDs; sensitivity analyses stratified by age and NSAID use. Results: Compared with upadacitinib, ruxolitinib showed higher reporting of GI motility disorders (803 events; aROR = 1.52, 95% CI 1.05–2.20) but markedly lower reporting of GI inflammation (641 events; aROR = 0.14, 0.07–0.29) and ulcer/perforation (229 events; aROR = 0.27, 0.10–0.68). Upadacitinib-related inflammation was dominated by ulcerative colitis (40.8 %) and Crohn’s disease (28.2 %), while 20.8 % of ulcer/perforation events were frank intestinal perforations. Median onset occurred within the first treatment year for both agents (8 months for upadacitinib ulcers/perforations; 6.5 months for ruxolitinib motility disorders). Age-stratified analyses confirmed an excess of upadacitinib-associated inflammation in adults and children, whereas ruxolitinib-related symptoms were concentrated in patients > 65 years. NSAID co-administration magnified upadacitinib-associated ulcers/perforations but had little effect on ruxolitinib patterns. Conclusions: In real-world practice, upadacitinib carries a substantially higher signal for severe inflammatory and ulcerative GI injury, whereas ruxolitinib is mainly associated with non-serious motility disturbances. Upadacitinib carries a higher signal for severe inflammatory and ulcerative GI injury, whereas ruxolitinib is mainly associated with non-serious motility disturbances. These associations are hypothesis‑generating rather than causal and warrant validation through prospective studies and mechanistic investigations.

Background:Anal fistula constitutes a pathological channel originating either from the anal canal or rectum to the skin surrounding the anus, primarily characterized by recurrent pain, purulent discharge, and pruritus. This study aims to compare and standardize the recommendations for the diagnosis and treatment of anal fistula, drawing on contemporary clinical practice guidelines. Methods:A comprehensive search was conducted across multiple databases including PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, and Chinese Biological Medicine Database, from their inception through April 1, 2024. The objective was to collate all published guidelines on anal fistula. The quality of the eligible guidelines was appraised by two reviewers using the Appraisal of Guidelines for Research and Evaluation II instrument. Results:The search yielded fifteen guidance documents -comprising nine guidelines and six consensus statements -each offering specific recommendations. Twelve of these documents address screening and diagnosis of anal fistula, while all fifteen discuss various treatment and management strategies. Document analysis highlighted MRI as the predominant diagnostic recommendation. Treatment and management strategies were categorized into four categories: preoperative management, surgical method selection, pharmacological interventions, and postoperative management. Regarding surgical interventions, all guidelines address incision and drainage of fistulas. Most guidelines offer a low recommendation for cutting setons, mainly attributed to the presence of incontinence. For high-positioned anal fistula, a push-pull flap procedure is recommended, whereas the LIFT procedure is advocated for newly identified, high, and sphincter-penetrating fistulas. Among the 15 guidelines and consensus statements evaluated in this study, more than half demonstrated methodological limitations, with particularly deficient performance in the applicability domain. As a critical determinant of implementation effectiveness, these deficiencies may undermine guidelines' capacity to optimize health outcomes. Conclusion:There is a pressing need for an updated search of potential evidence on the diagnosis and treatment of anal fistula. Effective diagnoses and therapeutic approaches, whether conventional or complementary and alternative medicine, should be thoroughly evaluated and incorporated based on robust evidence.

Objective: The incidence and mortality of colorectal cancer (CRC) have been increasing, making research into factors related to CRC necessary. This article aims to differentiate characteristics of gut microbiota between CRC patients and healthy individuals, and employs machine-learning algorithms for predicting specific microbial taxa. Methods: We conducted a multicenter case-control study starting in 2020, used 16S rRNA gene sequencing to analyze the gut microbiota in newly diagnosed CRC patients and healthy individuals. We used Python (version 3.9) to develop predictive models based on machine-learning algorithms. Results: Our research indicates a significant abundance of Escherichia-Shigella and Bacteroides in CRC patients, while Blautia and Faecalibacterium notably increased in healthy individuals. Using the Lasso model, we identified eight specific microbial taxa associated with CRC patients and thirteen taxa associated with healthy individuals. Discussion: The research highlights significant increase of various microbial taxa associated among CRC patients and healthy individuals, and also some microbiota with contentious functionalities. Among the machine-learning algorithms tested, the Random Forest model proved most suitable for predictive modeling in this region.

Stapled hemorrhoidopexy has been used for years to treat hemorrhoids. Despite numerous systematic reviews and meta-analyses on the topic, inconsistent conclusions have left people uncertain about its effectiveness and raised doubts about the quality of these reviews.In order to provide reliable evidence for clinical practice, it is crucial to conduct an overview to assess the quality of MAs/SRs regarding the efficacy and complications of SH.A comprehensive search was performed across seven databases to identify MAs/SRs on the efficacy and complications of SH from inception to October 2023. The selected MAs/SRs were then assessed using three well-established tools: AMSTAR-2, PRISMA 2020and GRADE. These assessments provide a robust evaluation of the quality and reliability of the included MAs/SRs.We removed overlapping randomized controlled trials (RCTs) and conducted a new meta-analysis of the outcomes. The overview included 23 meta-analyses.In AMSTAR-2, three reviews were deemed moderate quality, nine reviews were classified as low quality, and eleven reviews were evaluated as critically low quality.In PRISMA 2020,certain deficiencies were exhibited, such as abstracts (0/23:0 %),final retrieval date (0/23:0 %), sensitivity analysis (6/23:26.09 %),publication bias assessment (11/23:47.83 %), the quality of evidence (2/23:8.70 %) and so on.In GRADE,twenty-six items were rated as moderate quality (27.96 %),forty-one items were rated as low quality (44.09 %) and twenty-six items were rated as critically low quality (27.96 %).SH has been found to be an effective intervention for reducing postoperative pain, shortening procedure time, and promoting wound healing. The re-analysis indicated that SH can reduce postoperative pain in hemorrhoid patients (odds ratio = 0.28, 95 % confidence interval [0.15,0.55], p = 0.0002; I2 = 74 %, p < 0.00001). But SH is associated with a higher risk of postoperative bleeding and recurrence of prolapse.Given that the reviews included in this overview were rated as low quality, caution should be exercised when interpreting the findings.

Transanal Opening of Intersphincteric Space (TROPIS) has emerged as a promising surgical approach for anal fistula management over recent years. This meta-analysis comprehensively evaluates the comparative efficacy and safety of TROPIS versus conventional treatments through systematic analysis of 24 clinical studies involving 2813 patients. Through systematic searches across 7 major biomedical databases (including PubMed, EMBASE, and Chinese repositories) from inception to March 2024, we identified comparative studies assessing TROPIS against six established interventions: incision-thread-drawing, seton placement, LIFT, EAFR, fistulotomy, and incision-suture techniques. Pooled analysis demonstrated TROPIS achieved superior clinical outcomes, with a 3.15-fold higher total efficacy rate (95 % CI 1.22-8.13, p = 0.02) and 64 % lower complication risk compared to conventional methods (OR 0.28, 95 % CI 0.18-0.42, p < 0.00001). Sensitivity analyses confirmed result stability across study designs, while publication bias assessment via funnel plots and Egger's test revealed no significant distortion. Importantly, TROPIS maintained its advantage across various complication subtypes including incontinence (OR 0.31), infection (OR 0.27), and recurrence (OR 0.19). These findings establish TROPIS as a clinically superior alternative that significantly improves therapeutic outcomes while reducing procedure-related risks, suggesting its potential to become the new reference standard in anal fistula management. The consistent results across diverse patient populations and comparator procedures underscore the robustness of this evidence synthesis.

ObjectiveThe objective was to evaluate ABSI’s association with depression and explore FBG as a possible mediating factor.MethodsData from 8,748 NHANES participants (2017–2023) were analyzed. Logistic regression analyses assessed ABSI-depression associations, while mediation models tested FBG’s intermediary role. We conducted stratified analyses and interaction test to assess the impact of gender, age, race, PIR, education, alcohol use, current smoking status, BMI, hypertension history and hypercholesterolemia history on the study outcomes.ResultsThe fully adjusted logistic regression models demonstrated a significant positive association between ABSI and depression (OR = 1.20, 95%CI: 1.00, 1.44, p = 0.0497). Stratified analyses and interaction test showed that this association was significant only among participants with some college education or above (P for interaction < 0.05). No significant interactions were found across other subgroups. Mediation analyses revealed that FBG partially mediated the relationship between ABSI and depression (15.8%, p < 0.0001).ConclusionABSI was associated with depression, potentially mediated through FBG.

Wound healing is a critical aspect of modern medicine, impacting patient health, quality of life, and healthcare resource allocation. Okanin, a flavonoid from the Asteraceae family, has shown potential in promoting wound healing. This study investigates okanin's key molecular targets, binding affinity, and mechanisms of action using network pharmacology, molecular docking, molecular dynamics simulations, and in vivo experimental validation. Okanin's potential targets were identified using the Comparative Toxicogenomics Database (CTD) and SwissTargetPrediction, while wound healing-related targets were sourced from GeneCards and DrugBank. Overlap analysis of these datasets revealed common targets. Key target proteins were filtered through protein-protein interaction (PPI) analysis using the STRING database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted using Metascape to build a drug-target-pathway-disease network. Molecular docking was performed with AutoDockTools, and binding affinity was evaluated through energy scores, particularly with AURKA and HDAC1. Molecular dynamics simulations with GROMACS confirmed the stability of okanin-target complexes. ADME/T properties were assessed using SwissADME and ProTox-3.0 to evaluate pharmacokinetics and toxicity. In vivo quantitative real-time PCR (qRT-PCR) was performed to assess the expression of selected target genes in a mouse wound model following topical okanin treatment. A total of 72 common targets were identified between okanin and wound healing. PPI network analysis highlighted 17 key targets, with molecular docking revealing the highest binding affinity for AURKA and HDAC1 (ΔG = - 8.8 kcal/mol for both). GROMACS were then run on the top complexes. Target-ligand stability was quantified by convergence of RMSD/Rg, sustained hydrogen-bond counts, and MM/GBSA binding free energies (AURKA, - 24.27 ± 3.65 kcal/mol; HDAC1, - 47.7 ± 1.60 kcal/mol), confirming robust interactions. SwissADME predicted good drug-likeness (MW = 288.25 g/mol; logP = 1.69; high GI and moderate skin permeability) and no P-gp liability, while ProTox-3.0 indicated low systemic toxicity (LD₅₀ = 2500 mg/kg). qRT-PCR results demonstrated that okanin treatment significantly downregulated AURKA and PIK3R1, while upregulating HDAC1, in wounded skin, supporting the predicted molecular interactions and regulatory functions. Okanin promotes wound healing through multiple molecular targets and pathways, including antioxidant, anti-inflammatory, and cell proliferation mechanisms. Its high binding affinity for AURKA and HDAC1, along with modulation of the IL-17 and AMPK signaling pathways, underscores its therapeutic potential. This study provides a comprehensive theoretical and experimental framework for the development of okanin as a topical agent for wound healing, with future research focusing on formulation development and translational applications.

IntroductionBidens alba is a traditional medicinal plant valued for its antioxidant, anti-inflammatory, and antimicrobial properties, largely attributed to flavonoids and terpenoids. However, the tissue-specific distribution and regulatory mechanisms of these metabolites remain poorly understood.MethodsWe employed a combined approach of reference-guided transcriptomics and widely targeted metabolomics to investigate the biosynthesis and accumulation of flavonoids and terpenoids in four tissues (flowers, leaves, stems, and roots) of B. alba.ResultsA total of 774 flavonoids and 311 terpenoids were identified. Flavonoids were enriched in aerial tissues, while certain sesquiterpenes and triterpenes accumulated in roots. Transcriptome profiling revealed tissue-specific expression of key biosynthetic genes, including CHS, F3H, FLS, HMGR, FPPS, and GGPPS, which corresponded with metabolite patterns. Several transcription factors, such as BpMYB1, BpMYB2, and BpbHLH1, were identified as candidates regulating flavonoid biosynthesis, with BpMYB2 and BpbHLH1 showing contrasting expression between flowers and leaves. For terpenoid biosynthesis, BpTPS1, BpTPS2, and BpTPS3 were identified as putative regulators of enzymes including GPPS and DXR, with BpTPS2/3 highly expressed in flowers.DiscussionThese findings provide new insights into the transcriptional and metabolic basis of tissue-specific secondary metabolism in B. alba. The identified candidate genes and regulatory factors represent valuable targets for future functional validation and hold potential for medicinal development and molecular breeding of this species.

BACKGROUND Sinonasal teratocarcinosarcoma (SNTCS) is a rare and highly invasive neoplasm originating from the nasal cavity and sinuses. Typically, it exhibits an invasive behavior towards adjacent structures; however, in exceptional instances, it may infiltrate the intracranial compartment. Due to the tumor's rarity and lack of distinctive features on computed tomography (CT) and magnetic resonance imaging (MRI) images, SNTCS is often misdiagnosed. CASE SUMMARY In this study, we present a case of SNTCS in a 56-year-old patient who exhibited unexplained cognitive impairment before admission. CT and MRI scans revealed the presence of a mass in the right nasal cavity, with lesions extending to the right ethmoid sinus and right frontal region. Subsequently, the patient underwent pathological examination for confirmation and received surgical intervention to excise the tumor. The future advancement in our understanding of this disease will significantly contribute to the precise diagnosis and treatment of SNTCS. CONCLUSION SNTCS is an exceptionally rare malignant tumor that originates from the nasal cavity and paranasal sinuses, presenting a diagnostic challenge due to its non-specific imaging findings. MRI accurately delineates the location, morphological characteristics, size, internal structure, extent of surrounding involvement, and metabolic information of the lesion. These aspects play a pivotal role in the precise localization and qualitative assessment of SNTCS. Nevertheless, a definitive diagnosis still requires a pathological biopsy.

The prevalence of pelvic organ prolapse (POP) has been steadily increasing over the years, rendering it a pressing global health concern that significantly impacts women’s physical and mental wellbeing as well as their overall quality of life. With the advancement of three-dimensional reconstruction and computer simulation techniques for pelvic floor structures, research on POP has progressively shifted toward a biomechanical focus. Finite element (FE) analysis is an established tool to analyze the biomechanics of complex systems. With the advancement of computer technology, an increasing number of researchers are now employing FE analysis to investigate the pathogenesis of POP in women. There is a considerable number of research on the female pelvic FE analysis and to date there has been less review of this technique. In this review article, we summarized the current research status of FE analysis in various types of POP diseases and provided a detailed explanation of the issues and future development in pelvic floor disorders. Currently, the application of FE analysis in POP is still in its exploratory stage and has inherent limitations. Through continuous development and optimization of various technologies, this technique can be employed with greater accuracy to depict the true functional state of the pelvic floor, thereby enhancing the supplementation of the POP mechanism from the perspective of computer biomechanics.

Rectal cancer (RC) is a globally prevalent malignant tumor, presenting significant challenges in its management and treatment. Currently, magnetic resonance imaging (MRI) offers superior soft tissue contrast and radiation-free effects for RC patients, making it the most widely used and effective detection method. In early screening, radiologists rely on patients’ medical radiology characteristics and their extensive clinical experience for diagnosis. However, diagnostic accuracy may be hindered by factors such as limited expertise, visual fatigue, and image clarity issues, resulting in misdiagnosis or missed diagnosis. Moreover, the distribution of surrounding organs in RC is extensive with some organs having similar shapes to the tumor but unclear boundaries; these complexities greatly impede doctors’ ability to diagnose RC accurately. With recent advancements in artificial intelligence, machine learning techniques like deep learning (DL) have demonstrated immense potential and broad prospects in medical image analysis. The emergence of this approach has significantly enhanced research capabilities in medical image classification, detection, and segmentation fields with particular emphasis on medical image segmentation. This review aims to discuss the developmental process of DL segmentation algorithms along with their application progress in lesion segmentation from MRI images of RC to provide theoretical guidance and support for further advancements in this field.

[Objectives] To evaluate the effectiveness of the incisional skin-bridge procedure in the treatment of posterior horseshoe perianal abscess based on finite element model. [Methods] A cohort of 120 patients with posterior horseshoe perianal abscess who underwent the incisional skin-bridge procedure in the Department of Anorectal Surgery, Affiliated People’s Hospital of Fujian Traditional Chinese Medicine University (Fujian People’s Hospital) from September 2020 to December 2022 were included. These patients were randomly assigned into either standard skin-bridge group or the wide skin-bridge group (60 patients each) using random number table. Three-dimensional finite element model for both the standard skin-bridge (model A) and wide skin-bridge (model B) were constructed. Stress and displacement metrics at various skin-bridge nodes during surgery were quantified and incorporated into their respective models. Six pivotal nodes were selected for model validation, followed by comparisons of displacement disparities between the two models and an evaluation of anal pressure three months post-surgery. [Results] Displacements measured surgically at 174 nodes in the standard skin-bridge group and 173 nodes in the wide skin-bridge group significantly deviated from the model prediction (P<0.05), whereas other nodes displacements measured surgically aligned with the model (P>0.05). Compared to model B, nodes 89, 173, and 257 located on model A’s inner skin-bridge edge showed markedly less displacements (P<0.05), while nodes 90 and 258 on the outer edge exhibited increased greater displacements (P<0.05). Inner edge displacements were substantially greater than those at the outer edge in both models (P<0.05). Postoperative three-month anal pressure revealed that the anal resting pressure and maximal contraction pressure of the standard skin-bridge group surpassed those of the wide skin-bridge group (P<0.001). [Conclusion] The finite element method efficaciously mirrors the biomechanical dynamics of incision and skin-bridge procedures for perianal abscesses. During surgery, the skin-bridge nodes endure varied tensile forces. Tailoring the skin-bridge design might be crucial in preserving postoperative anal integrity and functionality following perianal abscess surgery.

目的 研究紫白膏对大鼠肛周创面愈合及转化生长因子β1(TGF-β1)、Smad3表达的影响.方法 将40只SD大鼠随机分为空白组、模型组、对照组和紫白膏组,每组10只.除空白组外,其余3组行大鼠肛周创面造模.模型组不予特殊治疗,紫白膏组、对照组分别予紫白膏和凡士林外敷干预,均连续干预14 d.观察4组大鼠治疗14 d后的创面愈合率;采用Western blot和qPCR检测大鼠创面组织中TGF-β1、Smad3蛋白及mRNA表达情况.结果 与空白组比较,模型组大鼠肛周创面愈合率明显降低(P＜0.05),创面组织TGF-β1、Smad3蛋白表达量和mRNA相对表达水平均明显提高(P均＜0.05);与模型组比较,紫白膏组和对照组大鼠肛周创面愈合率均明显提高(P均＜0.05),创面组织TGF-β1、Smad3蛋白表达量和mRNA相对表达水平均明显降低(P均＜0.05);与对照组比较,紫白膏组大鼠肛周创面愈合率均明显提高(P＜0.05),创面组织TGF-β1、Smad3蛋白表达量和mRNA相对表达水平均明显降低(P均＜0.05).结论 紫白膏可能通过调控大鼠创面组织TGF-β1、Smad3的表达来促进肛周创面愈合.

目的 研究紫白膏对大鼠创面修复的疗效及其作用机制.方法 采用随机数字表法将90只8周龄清洁级雄性SD大鼠分为空白组、模型组、凡士林组、紫白膏组、大青叶组、莫匹罗星软膏组,每组各15只.空白组行大鼠背部创面常规建模,其余各组行模拟人肛门环境建模,观察不同药物治疗下大鼠皮肤创面的愈合率.采用ELISA法测定各组大鼠治疗后第3、7、14天皮肤创面组织中IL-1β、TNF-α的含量.结果 治疗后第14天,凡士林组、紫白膏组、大青叶组的创面愈合率明显高于模型组(P＜0.05),莫匹罗星组与模型组愈合率差异无统计学意义(P＞0.05).ELISA结果表明大鼠造模后,IL-1β及TNF-α的含量均显著升高(P＜0.05).治疗后第7天,与模型组比较,紫白膏组IL-1β显著下降,紫白膏组、大青叶组TNF-α显著下降(P＜0.05).治疗后第14天,与模型组比较,紫白膏组的IL-1β显著下降(P＜0.05).治疗后第14天,与模型组比较,紫白膏组、大青叶组和莫匹罗星软膏组的TNF-α均显著下降(P＜0.05),与凡士林组比较,紫白膏组TNF-α显著下降(P＜0.05).结论 紫白膏可通过调控IL-1β、TNF-α的表达促进大鼠创面组织愈合.