The review summarizes the kidney protective mechanism of sodium-glucose-coupled transporter 2 inhibitors and their efficacy and safety for diabetic recipients of kidney transplantation.It is intended to improve patient outcomes.

BACKGROUND:Minimal change disease (MCD), a pathological type of nephrotic syndrome (NS), can occur in patients with tumors. We report two adult cases of MCD associated with papillary thyroid carcinoma (PTC), known to be extremely rare in adults.CASE PRESENTATION:A 35-year-old female patient was simultaneously diagnosed with MCD and PTC. The MCD was effectively treated with thyroidectomy and prednisone.In addition, a 50-year-old male patient, who had been diagnosed with PTC three years prior, had MCD confirmed by renal biopsy. The patient achieved complete remission following treatment with tacrolimus and rituximab.CONCLUSIONS:The present case report describes and discusses the diagnostic and treatment processes employed in these two patients. Clinicians need to be aware of the renal effects of treating patients with solid tumors.

干燥综合征肾损害以肾小管间质损害为主，累及肾小球较少见。本文报告1例经唇腺和肾活检证实的原发性干燥综合征合并膜增生性肾小球肾炎病例。患者以大量蛋白尿起病，经激素联合羟氯喹、环孢素等药物治疗后病情好转。

CD5抗原样蛋白（CD5L）是一种可溶性糖蛋白，与其相应受体结合发挥不同生物学效应。近年来，CD5L在肾脏疾病中的作用逐渐受到重视。本文就CD5L的生物学功能及其在急性肾损伤与慢性肾脏病中的最新研究进展作一综述。